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Biomedical subjects

G G Persijn

Publications and source records attributed to G G Persijn.

At least 145 records · Page 8Linked to original sources
PubMed1982

Effect of HLA-A and HLA-B matching on survival of grafts and recipients after renal transplantation.

Data on the effect of HLA-A and HLA-B matching between unrelated donors and recipients focus mainly on graft survival. After linking the follow-up data of the European Dialysis and Transplant Association and those of the Eurotransplant Foundation, the effect of HLA-A and HLA-B matching on recipient survival could be studied. Recipients of well-matched kidneys--i.e., without mismatches for the HLA-A and B antigens--had 51 per cent graft survival at five years, whereas recipients of grafts mismatched for four antigens had 32 per cent graft survival at five years. The overall P value between the five different mismatch classes was 0.0005. Patient survival at five years was 72 per cent in recipients of a kidney without HLA-A and B mismatches and 54 per cent in recipients of a completely mismatched donor kidney (overall, P = 0.001). These results suggest that matching for the HLA antigens has a beneficial long-term effect not only on renal-allograft survival but also on patient survival.

Actuarial Analysis↗
PubMed1982

Influence of prophylactic treatment with gamma-immunoglobulins on renal function after kidney transplantation in rhesus monkeys.

The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated animals had been given three pretransplant blood transfusions, graft survival ranged from 9 to 61 days with 42% of the animals showing a prolonged survival time (greater than 22 days). However, in both transfused and nontransfused recipients, the additional pretransplant administration of IgG appeared to have an adverse effect: about 25% of the animals showed accelerated rejection. In addition, serum creatinine levels in IgG-treated recipients were significantly higher on the 3rd day after transplantation than in non-treated monkeys. We concluded that renal transplant patients should be treated with IgG for protection against life-threatening infections only if they have good kidney function.

Animals↗
PubMed1982

Different influences on corneal graft survival in 539 transplants.

Different influences on corneal survival were studied in 539 grafts. The follow-up period ranged from 3 months to 4 1/2 years. The degree of vascularization of the host cornea, previous graft failures and the diameter of the graft could be demonstrated to influence the graft survival significantly. A significant influence of sex differences between donors and recipients was found. A female donor results in a better graft survival in female recipient as compared to male recipients. No significant influence on graft survival was found of pregnancies and blood transfusions. Age of the donor, storage methods and time lapse between death and transplantation did not influence the graft survival either.

ABO Blood-Group System↗
PubMed1982

The effect of prospective HLA-A and -B matching on corneal graft survival.

The effect of prospective HLA-A and -B matching on corneal graft survival was studied in 159 Dutch recipients. The follow-up period ranges from 3 months to 4 1/2 years. In the same period 380 grafts were performed at random. The influence of HLA-A and -B matching on graft survival in all vascularized cases (n = 137) was significant (P = 0.046). If the non-immunological failures are excluded the effect of HLA-A and -B matchings becomes more pronounced (P = 0.027). The influence of HLA-A and -B matching on the graft survival of only the first grafts in vascularized corneas was more significant (p = 0.028). Finally a significant influence of HLA-A and -B matching was also found in repeated grafts in vascularized corneas (P = 0.037).

Corneal Transplantation↗
PubMed1981

Results of renal transplantation using grafts from cadaveric donors over 50 years of age.

In view of the persistent shortage of organ donors, the usability for transplantation of cadaveric kidneys from donors over 50 years of age was studied. Out of 5546 cadaveric kidneys, transplanted in the Eurotransplant area in the past ten years, 149 were from donors over 50 years of age. Apart from an increased early graft loss in the advanced age donor group, comparison of cumulative graft survival showed no negative influence of progressing donor age. It is concluded that donors over 50 years of age can be a valuable source of cadaveric kidneys for tranplantation. Inclusion of these donors in harvesting programmes will result in a considerable increase in the amount of potential kidney donors.

Cadaver↗
PubMed1981

Should the upper age limit for cadaveric kidney donors be changed?

In view of the persistent shortage of donor organs a retrospective study was performed to determine whether the upper age limit for cadaveric donors can be changed. As in many transplant centres the arbitrary age limit of 50 years is in use, we studied the results of transplantation of kidneys from donors over 50 years of age. Out of 5546 cadaveric kidneys, transplanted in the Eurotransplant area in the past ten years, 149 were from donors over 50 years of age. Apart from an increased early graft loss in the advanced age donor group, comparison of cumulative graft survival showed no negative influence of progressing donor age. The graft function, measured by creatinine clearance, was satisfactory. It is concluded that donors over 50 years of age can be a valuable source of cadaveric kidneys for transplantation. It seems justified to change the upper age limit for cadaveric kidney donors from 50 to 60 years of age, resulting in a considerable increase in the amount of potential donors.

Adult↗
PubMed1979

Influence of previous immunization on skin graft survival.

The results of skin grafts transplanted in immunized and nonimmunized recipients was analysed. Specific sensitization for HLA-A or B determinants shortens graft survival if the recipients were immunized by s.c. injections of leukocytes. When the recipients had been pregnant, no such influence of specific HLA-A or B sensitization could be demonstrated. The variance in mean survival times of grafts exchanged between mixed lymphocyte culture (MLC)-positive donor-recipient combinations was significantly smaller than the variance in mean survival time (MST) of grafts exchanged between MLC-negative combinations. This difference could be the result of the influence of allograft immune-activating determinants of different strength in the MLC-negative donor-recipient combinations. Also the variance in MST of grafts in immunized recipients was significantly larger than the variance in MST of grafts in nonimmunized recipients. Apart from the obvious effect of HLA-A and B sensitization, other less well documented factors must have influenced graft survival. We did not find evidence for a graft enhancing effect of B cell-specific antibodies.

Antibodies↗