Biomedical subjects
G G Lanza
Publications and source records attributed to G G Lanza.
Oestrogen and progesterone sensitivity in cultured meningioma cells.
Several studies have detected oestrogen and progesterone receptors in meningioma specimens; recently we have also confirmed the presence of steroid receptors in cultured cells from meningiomas. This paper describes the oestrogen and progesterone receptor assay in cultured cells from 6 meningiomas and the influence of steroid hormones on the cell growth and morphology. Four (66%) of the 6 specimens were positive for both receptors. Growth of cultured cells from tumours without receptors is not appreciably modified by the addition of hormones; the cultured cells from tumours with positive receptors are not essentially influenced by oestrogen, whereas progesterone produces a rapid and marked suppression of the cell growth and modifies their form and adhesivity; also the addition of an oestrogen and progesterone blend produces growth suppression. A similar effect of the progesterone on the cultured cells has also been obtained in a specimen of malignant meningioma. The results of this study suggest that the modulation of progesterone levels may be of therapeutic usefulness, particularly in patients with recurrent malignant meningiomas.
[Familial sudden death in preexcitation syndrome. Surgical interruption of the anomalous pathways in two brothers (author's transl)].
We describe the results of surgical dissection of multiple accessory pathways in two brothers. A significant family history of pre-excitation syndrome was present: two children died suddenly and at the autopsy of one of them an accessory atrioventricular connection was found. In the first patient the preoperative electrophysiologic study showed anterior septal and posterior septal accessory pathways, and enhanced conduction in the A-V node. The second patient had the following anomalous connections: enhanced conduction in the A-V node; anterior septal, posterior septal and right lateral accessory pathways; Mahaim fiber. Intraoperative mapping, performed during pacing from different sites at different cycle length, was used to define the atrial and ventricular insertions of the accessory pathways as well as to confirm the surgical success.