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Biomedical subjects

G G Karpel'

Publications and source records attributed to G G Karpel'.

15 recordsLinked to original sources
PubMed1980

[Immunologic reactivity in the acute phase of a stroke].

Examinations of the clinical and immunological state of 68 patients with the acute stage of cerebral stroke were carried out, and so were immunomorphological examinations of the spleen and the subclavicular lymph nodes in 36 of them whose disease ended in death. An analysis of the results obtained has shown that the immunological reactivity increases from the very first day of the disease. The authors believe that the early immunological response, especially in cases of brain infarction, is due to development of the cerebral stroke in a sensitized body. A rise of selective antibody titres depending on the character of the cerebrovascular disorder was noted: there were: anti-encephalic antibodies targeted at the malacia focus in cases of brain infarction, and antivascular, and to a lesser extent anti-encephalic antibodies in cases of a hemorrhagic stroke. The informative value of the complement fixation test was found to be greater than that of the hemagglutination inhibition test. High degrees of plasmatization of the splenic tissue and the presence of the anti-encephalic immune complexes in it, mainly in cases of brain infarction, also point to the activity of the immunogenesis in the acute stage of the cerebral stroke.

Acute Disease↗
PubMed1980

[Mediastinal mesenchymoma].

An observation of a rare mediastinal tumor, malignant mesenchymoma, removed at thoracotomy in a woman of 30 is described. The cellular atypism of the tumor increased in the course of two relapses.

Adult↗
PubMed1978

[Alkaline phosphatase and ATPase activity in the walls of the cerebral vessels in hypertension and arteriosclerosis with disorders of the cerebral circulation].

In hypertensive disease and atherosclerosis without acute disorders of cerebral circulation it was established that in the cerebral vessel walls there was a high activity of alkaline phosphatase and adenosintriphosphtase. In the symmetrical areas of the subcortical nodes differences in the activity of these enzymes were insignificant and not valid. In vessel walls, located in the peripheral zone of the apoplectic hemorrhage and in the adjacent brain tissue the activity of alkaline phosphatase and adenosintriphosphatase drops. The existence of a high activity of enzymes in the vessel walls on the early stages of hemorrhages gives ground to the authors to claim that in the peripheral zone of an extensive hemorrhage a drop in the enzyme activity appears in the process of a development of a stroke.

Adenosine Triphosphatases↗
PubMedDate not supplied

[Hemangiomatosis].

The authors discuss the possibility of systemic hemangiomatosis that is difficult to diagnose and treat. In the case they dealt with a disseminated involvement of the oral cavity was combined with lymph node angiomas and, possibly, with angiomas of other organs. The condition had to be differentiated from tuberculosis, Hodgkin's disease, leukemia, and multiple tumors.

Diagnosis, Differential↗
PubMedDate not supplied

[Mechanism of disorders of the cerebral blood supply during stress in spontaneously hypertensive rats].

The immobilization- and sound stimulus-induced changes in cerebral circulation were studied in spontaneously hypertensive rats. It was found that there was a stress-induced increase in the levels of epinephrine and norepinephrine in brain tissue, which was associated with lower levels of vasoactive prostaglandins E and F2 and with their imbalance with vasodilator prostaglandins E being prevalent. The change in the cerebral ratio of biologically active substances results in cerebral blood flow autoregulation failure and development of large cerebral hemorrhages.

Animals↗