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Biomedical subjects

G G Jackson

Publications and source records attributed to G G Jackson.

120 records · Page 7Linked to original sources
PubMedDate not supplied

A new generation of beta-lactam antibiotics: anticipating future developments and needs.

The development of a drug with the properties of moxalactam creates both a new class of beta-lactam antibiotics and potentially a new era in chemotherapy. The specific activity (antibacterial effect/mg), stability against enzymatic degradation, and pharmacologic advantages of moxalactam provide new promise for the treatment of some infections and for moving forward our understanding of bacterial properties and the processes of infection. Such conditions offer numerous opportunities for development of new knowledge and improved practices in antimicrobial therapy. As the quality of antibiotics is improved through modification by chemical synthesis, some biologic and clinical needs shift. Experience provides a basis for anticipation and recognition of some of the conditions that are most likely to occur. Physicians should be alert to these possibilities and to their opportunity for making observations that will establish the optimal use of moxalactam, the first of a new generation of beta-lactam antibiotics.

Anti-Bacterial Agents↗
PubMedDate not supplied

Antiviral chemotherapy--a frontier for health and learning.

Antiviral chemotherapy has been too long perceived as being relatively impossible. Such notions adversely affect the acquisition of important specific clinical information, whereas much new knowledge is available about viral replication and cell biology which enhances the prospects for effective chemotherapy. Some immediate goals can be recognized that will further determine the ability to influence viral infections and properly interpret the drug effects. In recent controlled observations there is reason for expectant optimism, but the demonstration of antiviral chemotherapy is both disease- and host-dependent, with important nonpharmacologic aspects. Rapid specific and sensitive diagnostic tests are of paramount importance; that they can be devised is a generally accepted conclusion among virologists. Problems in the scientific evaluation of antiviral chemotherapy in man have led to the recommendations of compounds that have no proved effect; amantadine, Ara A, and interferon, however, have been shown to be efficacious. Acyclovir and bromvinyldeoxyuridine have demonstrated virus-directed chemotherapy with impressive specificity. The frontier of antiviral chemotherapy holds great promise for additional learning and improved health through the implementation of developing knowledge.

Antiviral Agents↗