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Biomedical subjects

G G Hermann

Publications and source records attributed to G G Hermann.

29 records · Page 2Linked to original sources
PubMed1989

[Scientific articles in Ugeskrift for Laeger during a 25-year period. Types of articles and experimental design].

The purpose of this study was to examine possible trends in the research designs used in Ugeskrift for Laeger during 25 years. The scientific articles in 12 issues of the journal selected at random from each of the years 1959, 1964, 1969, 1974, 1979, and 1984 were reviewed. From each article, the following information was obtained: type of article (original paper, case report, or review), origin of the paper and number of authors. For the original papers, it was noted whether it was a longitudinal or a cross-sectional study, and whether it was a cohort or a trohoc study. Furthermore the number of subjects and the use of control group, randomization and blinding were registered. The number of articles and the number of authors per article increased during the period. Contrary to similar studies of some widely circulated English-language journals, we could not demonstrate any increase of the frequency of studies with weak research design. On the other hand, no striking improvement was observed either. Most studies had no control group and randomization and blinding were used in less than 10% of the original papers. The present study does not permit an evaluation of whether the research designs used i Ugeskrift for Laeger are satisfactory.

Denmark↗
PubMed1989

[Scientific articles in Ugeskrift for Laeger during a 25-year period. Analysis and interpretation of research results].

During a period of 25 years from 1959 to 1984, no essential alteration in the employment of descriptive statistics was observed in the original articles in the Ugeskrift whereas analytical statistics was employed to an increasing extent. In all of these volumes, defective, incorrect or less suitable employment of statistics could be demonstrated. Common problems were: analyses of materials in which some patients participated once while others participated on several occasions; debatable analyses of data on ranking scales; employment of 2-group tests on several groups; insufficient analysis of cross-over trials; lack of confidence intervals, and circular reasoning.

Denmark↗
PubMed1988

Early secondary suture versus healing by second intention of incisional abscesses.

A controlled trial was set up to compare the treatment of wound abscesses, occurring after laparotomy, with either early secondary suture combined with cefuroxime and metronidazole given intravenously or by healing by second intention. The secondary suture was performed two days after wound drainage and resulted in a significant reduction (p less than 0.01) in healing time without complications. No reinfections occurred.

Abscess↗
PubMed1986

[Suprarenal cysts].

Explore the source record for details and available documents.

Adrenal Gland Diseases↗
PubMed1984

Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases.

A case of primary hemangiosarcoma of the spleen in a 48-year-old woman is presented. Twenty-eight months after splenectomy the patient developed a severe anemia of the microangiopathic type, thrombocytopenia, and a leukoerythroblastic peripheral blood picture. In contrast to x-ray and conventional 99mTc-methylene-diphosphonate (MDP) bone scintigraphy, which showed only a few minor focal changes in the spine and ribs, angioscintigraphy with in vitro labeled 99mTc-erythrocytes revealed extensive pathologic accumulations throughout the spine, femurs, and the liver, indicating the presence of extremely vascular metastases. Autopsy 15 months later confirmed the scintigraphic findings. Angiography with 99mTc-labeled erythrocytes seems to be useful for monitoring metastases from hemangiosarcomas.

Anemia↗
PubMedDate not supplied

LAK-cell-mediated cytotoxicity against tumor cell targets used to monitor the stimulatory effect of interleukin-2: cytotoxicity, target recognition and phenotype of effector cells lysing the Daudi, T24 and K562 tumor cell lines.

The T24 transitional bladder carcinoma cell line, the Daudi Burkitt lymphoma cell line and the K562 erythroleukemia cell line have all been used as target cells in 51Cr release assays to measure the in vivo induced lymphokine-activated killer (LAK) cell cytotoxicity during interleukin-2 (IL-2) therapy of cancer patients. However, different relationships between the clinical response to IL-2 treatment and the LAK cytotoxicity have been reported using these three different target cells. The purpose of the present study was to evaluate whether the LAK cytotoxicities measured against these target cells represent similar effector-to-target-cell interactions, so similar conclusions may be drawn of 51Cr release assay results in which the cell lines are used as target cells. The cytotoxicity of peripheral blood mononuclear cells (PBMC) and PBMC depleted of different natural killer and T cell subsets was measured against the three targets. LAK cell recognition of targets was evaluated by cold target inhibition experiments, and the development of LAK-cell-mediated lysis with time was evaluated in 51Cr release assays of varying duration. This study shows that LAK-mediated lysis of T24 and Daudi cells was closely related and LAK cytotoxicity measured in 51Cr release assays against these two target cells may be measurement of similar effector-to-target cell interactions.

Antigens, CD↗