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Biomedical subjects

G G Graham

Publications and source records attributed to G G Graham.

At least 91 records · Page 5Linked to original sources
PubMed1984

Effect of father's death or departure on growth of poor children in Peru.

Between 1966 and 1976, heights and weights were determined yearly on all available children from 163 families who had had at least one child successfully treated for malnutrition between 1961 and 1971 and from eight families who had adopted such a child. Between 1959 and 1976, a total of 72 fathers departed from these families: 12 died, 47 deserted, six were jailed, and seven left to look for work elsewhere. Heights and weights as Z scores and the weight age/height age ratios were analyzed, when available, during four periods around the date of the event: 6 to 18 months before (period 1B), 0 to 6 months before (period 2B), 0 to 6 months after (period 3A), and 6 to 18 months after (period 4A). Mean Z scores for all children measured in the period were already low (-0.26 +/- 0.93 and -0.25 +/- 0.95) during period 1B, were higher during period 2B, (-0.15 and 0.04), lower during period 3A (-0.39 and -0.46), and similar to original levels during period 4A (-0.37 and -0.27). Mean weight age/height age was low (0.93 +/- 0.17) only during period 3A for children 2 to 18 years of age. In paired comparisons for children measured during any two periods there were significant increases in Z height and Z weight from periods 1B to 2B and from periods 1B to 4A in children less than 2 years of age and a significant decrease in the weight age/height age ratio from periods 1B to 3A in those 2 to 18 years of age. Loss of father had little or no further impact on the already poor growth of these children.

Adolescent↗
PubMed1983

The effect of decortication and extrusion on the digestibility of sorghum by preschool children.

The effect of decortication and extrusion on the apparent protein quality and digestibility of sorghum (S. vulgare) was evaluated in comparative balance studies in nine children 7-24 months of age. Sorghum provided (as kilocalories) 8% protein and 62% carbohydrate in the study diet. Lysine was supplemented to 3% of protein. Casein provided 6.4% protein kilocalories in the control diet. A mixture of sucrose, dextrimaltose and cornstarch provided carbohydrate. Both diets contained 30% fat kilocalories as soybean-cottonseed oil blend. Balance studies were carried out during the last 6 days of three 9-day dietary periods: control-sorghum-control. Apparent N absorption from sorghum was 81 +/- 4% and did not differ from control. Apparent N retention, 21 +/- 6%, was expectedly lower than the preceeding control (27 +/- 8%, P less than 0.05) and following control (33 +/- 7%, P less than 0.01) values. The control values differed significantly from each other (P less than 0.05). Fecal weights and energy losses showed only minor differences between the two diets. These data contrast sharply with previous results obtained with whole-grain sorghum and suggest that the use of decortication and low cost extrusion processing can markedly improve the apparent protein quality and digestibility of sorghum.

Caseins↗
PubMed1983

Protein quality and oil digestibility of Lupinus mutabilis: metabolic studies in children.

The nutritional quality of lupins (Lupinus mutabilis) for infants and children was evaluated in two sets of balance studies. In the first the digestibility and protein quality of diets based on lupin flour, with and without methionine supplementation, were compared with those of a control diet consisting of casein, sucrose and vegetable oil. Apparent nitrogen absorption from lupin flour (81.8 and 84.3% of intake) was slightly but significantly less than that during casein control periods (87.2 and 86.8% of intake, P less than 0.05 and less than 0.001). Apparent nitrogen retention from unsupplemented lupin (15.6 +/- 5.8% of intake) was significantly less than that from casein in the corresponding control periods (29.8 +/- 4.9%, P less than 0.001); a small but significant (P less than 0.05) increase in nitrogen retention was observed during the control period following the lupin diet when compared with that preceding it. Methionine supplementation of lupin produced a marked improvement in apparent nitrogen retention (to 22.2 +/- 6.9%, P less than 0.05). In the second set of studies the digestibility of lupin oil was compared with that of a blend of soybean and cottonseed oils (50:50). Excretion of fecal fat (9.8 +/- 3.0% of intake) and fecal energy (6.7 +/- 1.2% of intake) with the diet containing lupin oil were similar to those observed with the control diet. Both the protein quality and oil digestibility of Lupinus mutabilis are very similar to those from soybeans processed in a similar manner. For certain countries the lupin could be a valuable source of protein and edible oil for human consumption.

Body Weight↗
PubMed1983

Plasma free amino acids in children consuming lupin protein with and without methionine supplementation.

Plasma free amino acids were measured in the fasting state and 3 and 4 hours postprandially in children after 9 days consumption of diets in which lupin provided all of 6.4-6.7% protein kcal, either with supplementation of 2% (grams/gram protein) DL-methionine (L & Met, n = 9) or with an isonitrogenous amount of urea (L & U, n = 10). Fasting concentration of total amino acids (TAA) and of essential amino acids (TEAA) and the TEAA:TAA molar ratio did not differ between diets. Fasting Met concentration (15 +/- 4 mumol/liter) and the Met:TEAA ratio (0.021 +/- 0.005) were markedly depressed after 9 days of L & U. Supplementation with Met caused an expected increase of Met concentration (25 +/- 6 mumol/liter) and the Met:TEAA molar ratio (0.039 +/- 0.007) and a profound decrease of Thr concentration (119 +/- 28 to 77 +/- 22 mumol/liter) and Thr:TEAA (0.165 +/- 0.027 to 0.124 +/- 0.028). Postprandially after L ", Met and Met: TEAA did not change from their low fast ing values. After L rMet, Met and Met:TEAA increased significantly relative to fasting values. Threonine concentration increased but the Thr:TEAA ratio decreased significantly (0.124 +/- 0.028 to 0.111 +/- 0.027). These studies confirm Met as the first-limiting amino acid in lupin protein and suggest that Thr becomes limiting when Met is provided in adequate amounts.

Amino Acids↗
PubMed1982

Later growth of malnourished infants and children. Comparison with 'healthy' siblings and parents.

Growth was evaluated in 144 boys and 71 girls hospitalized for malnutrition from 1961 through 1971 at mean ages of 13.1 and 10.7 months, respectively. During the period 1961 through 1966, ex-patients were measured at irregular intervals, while from 1966 through 1976, ex-patients and siblings were measured yearly. Average follow-up was seven years. Female ex-patients were 2.0 cm shorter than boys at 1 year and 7.0 cm taller at 13 years; their better growth was possibly due to earlier hospitalization, more adoptions, and renewed pubertal "catch-up." Ex-patents were compared with siblings at the same age; girls apparently caught up with sisters during puberty and both matched or exceeded maternal heights, while boys lagged behind brothers. Stunting, usually reported after severe infant malnutrition, seems more the result of continued poor environment and diet than of a limited episode of marasmus or kwashiorkor.

Adolescent↗
PubMed1982

Noninvasive chemical methods of estimating pharmacokinetic parameters.

Two noninvasive methods have been advocated for pharmacokinetic and bioavailability studies. The measurement of the salivary and urinary excretion of drugs and their metabolites may avoid sampling blood, particularly in introductory studies. The measurement of the salivary concentrations of drugs is of most value in studies on compounds which are little ionized at physiological pH values. Well studied examples where there is a good parallelism between salivary and plasma drug concentrations include the neutral drug, ethanol, the weakly acidic drugs, phenytoin and sulphapyridine, and the weakly basic drugs, carbamazepine and antipyrine. Data on the salivary secretion of more strongly acidic or basic drugs are often conflicting and further work is required to determine the usefulness of measuring the salivary secretion of such drugs in pharmacokinetic and biopharmaceutical studies. Studies on the rate of excretion or cumulative excretion of drugs and their metabolites in urine may provide good estimates of the terminal half lives of drugs. However, accurate determinations of the kinetic parameters of rapid processes are not obtainable from studies on urinary excretion. Reliable data can only be obtained if the timing of urine collections is precise and if there are no significant losses of urine.

Biotransformation↗
PubMed1982

Antimalarials in rheumatic diseases.

The use of antimalarials in rheumatoid arthritis (RA) and systemic lupus erythematosis (SLE) has declined over recent years due to concern over retinal toxicity and the impression that this class of drugs is relatively ineffective in rheumatic diseases. Recent reviews suggest that this position should be changed. Firstly, there is now good evidence for the efficacy of these drugs in RA and secondly strict control of the daily dosage and careful ophthalmological surveillance can almost eliminate the risk of serious retinal toxicity.

Antimalarials↗
PubMed1982

Experience with a mixture of wheat-noodles and casein in the initial dietary therapy of infants and young children with protein-energy malnutrition or acute diarrhea.

The usefulness of a mixture of wheat noodles and a casein-based formula in the early management of 11 children with second or third degree malnutrition and of ten better nourished children with acute diarrhea was studied. Response of the malnourished children, gauged by clinical course and balance studies, paralleled that previously documented using only casein-based formula diets. Children with acute diarrhea recovered well but had expectedly higher fecal energy losses than previously seen in healthy children consuming the same diet. Diets containing substantial amounts of wheat noodles, a low cost widely available staple, can be appropriately used in the refeeding of chronic malnutrition and acute infectious enteritis.

Acute Disease↗
PubMed1981

Salicylate metabolite kinetics after several salicylates.

Single oral doses of aspirin (ASA, 1,500 mg), sodium salicylate (NaSA, 1,500 mg, 1,200 mg), and salicyluric acid (SUA, 500 mg) were given to five subjects. Serial plasma and urine samples were collected for 24 hr (plasma) and up to 48 hr (urine); salicylic acid (SA), SUA, and gentisic acid (GA) were measured by high-pressure liquid chromatography. The plasma concentration/time profiles for SUA after ASA and NaSA were fitted to the empirical equation CpSUA = A-Bt-Ce-alpha t -- (A-C)e-beta t. Michaelis constants (Vm and Km) for the conversion of SA to SUA were calculated from the equation (formula see text), where Cl is the renal clearance of SUA, ke is the rate constant of elimination of SUA, CpSA is the plasma concentration of salicylic acid. The term Cl (formula see text) is the estimated rate of formation of SUA from SA at any time (t). The calculated values (mean +/- SD) of Vm, Km, and Kmf (Km in terms of unbound SA) were 43.4 +/- 10.1 mg SA/hr, 14.3 +/- 3.4 mg SA/l plasma, and 0.75 +/- 0.15 mg unbound SA/l plasma. The Vm values were in accord with those reported, but the value for Km was considerably lower. Renal clearances of SUA and GA were 340 +/- 51 and 65 +/- 10 ml/min.

Adult↗
PubMed1981

Preterm milk.

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Female↗
PubMed1981

Determinants of growth among poor children: nutrient intake-achieved growth relationships.

Seven-day individual weighed dietary intakes and anthropometric measurements were determined in 123 children, 2 to 19 yr of age, from 26 poor families in Lima: each included one child who had been malnourished, six were adopting families. Heights and weights were converted to "ages" based on Boston reference data and local data, then to "quotients" as percentages of actual ages. Mineral and vitamin intakes were expressed as amounts per day and per 1000 kcal, calories and protein as percentages of FAO/WHO recommendations for age and height age and of modified recommendations based on size of Peruvian children. Regression analyses identified common sources of nutrients and greater dependence of intakes on body size than on age. Analysis of covariance for sex identified different nutrient-growth correlations. Polynomial regression analysis identified percentage protein from animal sources and percentage fat calories as having significant quadratic as well as linear correlations with achieved growth. In males, multiple regression analysis identified percentage protein from animal sources and beta-carotene intakes as strongly associated with achieved height and weight, and percentage fat calories as strongly associated with weight quotient/height quotient ratios. In females the correlations were not as strong, possibly because a significant percentage had reached the menarche some time before the survey and were probably no longer growing. Nevertheless, calorie intake, as a percentage of the recommendation for height age, was prominent in the regressions for height quotient and percentage fat calories in that for weight quotient. The very strong association of animal protein intake with male height, despite seemingly generous total protein intakes, is difficult to reconcile with current recommendations. The possible role of vitamin A (as beta-carotene) has potentially important implications for food policies.

Adolescent↗
PubMed1981

Determinants of growth among poor children: relation of nutrient intakes to expenditure for food.

The growth status and the nutrient intakes of 123 children from 26 urban poor families in Peru were related to per capita expenditure for food. Children from six better off families were taller and heavier (p less than 0.001), with no difference in weight for height. They had significantly higher calorie and total protein intakes (as percentage of recommended) and higher intakes of animal protein, fat, calcium, carotene, riboflavin, and vitamin C. When macronutrient intakes were expressed as percentages of recommended calorie intakes, correcting for age and relative size, all of the increase in total protein intake was due to animal protein, vegetable protein remaining constant. Almost all of the increase in adequacy of total calories was due to increasing fat intakes, relatively much less to carbohydrate, and this only among the poor families. In this population, as more money becomes available to purchase food, there is an increase in animal protein and fat intakes, over an almost constant vegetable protein and carbohydrate intake. There is a simultaneous increase in consumption of fruits and vegetables, accounting for increases in the carotene and vitamin C intakes.

Adolescent↗
PubMed1981

Determinants of growth among poor children: effect of expenditure for food on nutrient sources.

The effect of increasing expenditure on the nature and the amounts of foods consumed by children from an urban population was estimated by studying the diets of 111 children from 20 typically poor families and those of 12 children from six economically better off families who had a much more satisfactory growth status. Total calories and protein, fat, and carbohydrate calories were expressed as a fraction of each individual's estimated energy requirement, thus adjusting for sex, age, and size. No important sex differences were found. Calorie intake was 87.2 +/- 17.3% and 111.4 +/- 18.1% of requirement for the two groups, respectively. Differences were found between the groups in protein calories which were totally due to milk and meat. Differences in fat calories were due to milk, meat, and separated fats. There was no significant difference between groups in total carbohydrate calories, although there were shifts in its components with increasing expenditure. Regression analysis of calorie adequacies as a function of per capita expenditure for food, both in the poorer group and in the combined population, were performed and yielded highly significant (p less than 0.001) results. These were due to significant gradual increases in the consumption of milk, meat, separated fats, fruits and vegetables on top of an almost constant consumption of the staple cereals, roots and tubers.

Child↗