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Biomedical subjects

G G Essed

Publications and source records attributed to G G Essed.

45 records · Page 3Linked to original sources
PubMed1984

Serum levels of ritodrine during oral maintenance therapy.

In order to elucidate some aspects of the efficacy of orally administered ritodrine, serum concentrations of ritodrine were determined during intravenous and oral therapy. Ritodrine serum concentrations during steady-state intravenous therapy (200 micrograms/min) ranged from 91.0 to 123.0 ng/ml. Serum concentrations during maintenance therapy with 120 mg ritodrine per os fluctuate between 3.2 and 30.5 ng/ml, depending on the moment of tablet intake. During oral maintenance therapy a striking correlation was found between the maternal heart rate and the serum concentration of ritodrine. The findings suggest that efficacy of orally administered ritodrine is doubtful on pharmacological grounds.

Administration, Oral↗
PubMed1984

Predictive value of uterine contractility and the serum levels of progesterone and oestrogens with regard to preterm labour.

A longitudinal investigation regarding the serum concentrations of oestradiol, oestriol and progesterone in relation to uterine activity has been performed in 80 healthy primigravid women during the course of pregnancy up to the 37th week of pregnancy. The frequency of uterine contractions was quantitatively objectivated by means of external toco-dynamometry; simultaneously the uterine activity has been recorded by the pregnant women qualitatively. It appears that there is a gradual increase of all the three mentioned hormones during the course of pregnancy. However, there is a large interindividual spread. There exists no relation between the hormonal serum levels and uterine activity (quantitatively as well as qualitatively recorded). Between these two latter there is a poor relation. It is impossible to predict the occurrence of preterm birth based on hormonal serum changes. This holds for the progesterone-oestradiol ratio.

Adult↗
PubMed1983

Amniotic fluid embolism after transabdominal amniocentesis.

Amniotic fluid embolism following transabdominal amniocentesis is a very rare and mostly fatal event. A case history is presented with the characteristic clinical findings in addition to disseminated intravascular coagulation immediately following an amniocentesis to assess fetal lung maturity.

Adult↗
PubMed1982

The influence of long term beta-mimetic drug administration during pregnancy on blood loss postpartum.

Early blood loss after-delivery was measured in all prematurely ending singleton pregnancies (amenorrhea 29-38 wk) during which the patients had been treated with beta-mimetics (ritodrine or fenoterol) for the prevention of premature labor, during a 4 yr study period (1975--1978) (n = 129). For comparison, postpartum blood loss was measured in the same way in all other (not treated) patients who delivered with the same gestational ages during the first 2 yr of the investigation (n = 176). Only vaginal deliveries were included and some patient categories were excluded. Placental weight and episiotomy status were found to effect the amount of early postpartum blood loss at a significant level. Blood loss after delivery was found not to be increased by chronic beta-mimetic treatment, even when this treatment ended less than 24 h before delivery. Moreover, when the treatment--delivery interval exceeded 24 h, the average amount of blood loss by treated patients was less than that of the untreated patients in some comparison categories. No difference in the amount of blood loss was found according to the specific drug that had been used.

Birth Weight↗
PubMed1978

Rectus hematoma: a clinical diagnosis confirmed by ultrasound.

In 2 women the diagnosis of rectus hematoma could be established by ultrasound and the further clinical course. Echoscopy is stressed as a technique which is helpful to the patient and the clinician in avoiding unnecessary operations.

Abdominal Muscles↗
PubMedDate not supplied

Comparison of Cytobrush sampling, spatula sampling and combined Cytobrush-spatula sampling of the uterine cervix.

Since the introduction of the Cytobrush for sampling the uterine cervix, some practitioners have ceased taking a concomitant cervical scraping using a spatula. To examine whether Cytobrush sampling alone is adequate for the diagnosis of cervical lesions, the Cytobrush and spatula samples in 444 smears (most with original diagnoses of at least mild dysplasia) were analyzed separately for the presence of diagnostic cells, endocervical cells and squamous cells. Of the 412 smears showing pathologic findings (mild to severe dysplasia or worse), diagnostic cells were present in 400 Cytobrush samples and in 369 spatula samples; the combination of both samples thus gave a 3% gain in correct diagnoses as compared to use of the Cytobrush samples alone. Another 18 smears would have been underdiagnosed based only on the Cytobrush samples. Endocervical cells were present in 95.3% of the Cytobrush samples and 83.8% of the spatula samples; squamous cells were present in 93.9% of the Cytobrush samples and 96.8% of the spatula samples. Analysis confirmed that it is important that the smear should contain both endocervical and squamous cells. A positive relationship between the absence of squamous cells in the Cytobrush sample and the probability of a false-negative assessment was suggested. It thus seems inadvisable to replace the combination sampling method by Cytobrush sampling alone, which may lead to a false-negative diagnosis.

Adult↗
PubMedDate not supplied

Biopharmaceutical aspects of ritodrine retard in pregnant women.

Biopharmaceutical aspects of the new sustained-release formulation of ritodrine, a tocolytic agent, were studied in 9 patients with preterm labour. A mean bioavailability of 26% (range 22%-32%) was estimated after the 4th day of treatment (steady state). A.U.C.'s from oral administration were found to correlate well with those measured in i.v. therapy in the same patients (r = 0.92; p = 0.0004). It was concluded that differences in bioavailability of ritodrine-retard are small enough to enable clinicians, using this sustained release preparation, to make fair estimations of the oral dosage, needed to replace the initial i.v. treatment.

Administration, Oral↗