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Biomedical subjects

G G Bazaz'ian

Publications and source records attributed to G G Bazaz'ian.

At least 19 recordsLinked to original sources
PubMed1987

[Decreased sensitivity to the hypoglycemic action of insulin in animals with a lowered blood heparin concentration].

It has been shown that in animals with reduced heparin blood concentration the hypoglycemic insulin action was considerably low. This was established for rats with alloxan diabetes and ageing rats with depressed anticoagulation system and atherosclerosis enhanced by prolonged atherogenic diet. With insulin injection (0.2-0.3 U/200 g), blood sugar concentration in such animals was 2-2.5 times lower than in normal ones. The compensation of endogenous heparin deficiency by an intravenous injection of heparin normalizes the reaction of animals to exogenous insulin.

Animals↗
PubMed1987

[Mast cell population in rats with experimental atherosclerosis].

Mast cell population was studied in rats with experimental atherosclerosis. It has been established that animals kept for 8 months on atherogenic diet revealed marked changes in mast cell population. Predominance of light cells and cell defects were noted. Heparin saturation index was reduced (0.35), as compared to the control (3.9). Stimulation of anticoagulation system by DIP-alpha-thrombin in such animals revealed no heparin in the blood. Mast cell subpopulation was characterized by light cell predominance and low heparin saturation index. The nature of cell degradation remained unchanged. The data obtained indicate the defects in mast cell pool in animals with experimental atherosclerosis.

Animals↗
PubMed1986

[Dependence of the blood plasma activity of the diabetogenic factor in animals on the functional depression of the anticoagulating system induced by an atherogenic diet].

It has been found that in blood plasma of rats keeping on an atherogenic diet for a long time the diabetogenic factor activity appears. The direct dependence between the level of the diabetogenic factor activity and the degree of the anticoagulating system depression caused by long keeping of the animals on the atherogenic diet has been revealed.

Animals↗
PubMed1986

[Changes in the structures of the cerebral cortex in experimental atherosclerosis with and without exposure to sound].

Albino rats fed an atherogenic diet for 3 months developed a marked depression of the anti-coagulation system of blood. The acoustic and sensomotor cortex showed dystrophic changes in the cortical structures, as well as signs of the reparative nature. Sound stimulation in the presence of atherosclerosis increased fibrinolytic activity and decreased heparin tolerance of blood plasma in animals sensitive to acoustic exposure and led to a greater severity and dissemination of dystrophic and destructive changes in the cortical structures, particularly in animals with convulsive seizures.

Animals↗
PubMed1984

[Role of heparin in the realization of the hypoglycemic action of insulin].

The presence of reactive heparin in blood circulation is necessary for realization of the hypoglycemic action of insulin. This is confirmed by the fact that after heparin binding by protamin sulfate both endogenous and exogenous insulin do not exhibit any hypoglycemic activity. In animals with different basal concentration of heparin in the blood, the blockade of insulin action is attained by application of different doses of protamin sulfate, respectively. Based on the data obtained one can determine an approximate blood heparin concentration necessary for realization of the hypoglycemic action of insulin.

Animals↗
PubMed1984

[Nutrition--a factor in preventing arteriosclerosis, coronary disease and disorders of the blood coagulation system. I. An imbalance in food fats and carbohydrates and atherogenesis].

The analysis of the literary data and the results of own research testifies that the lipids and carbohydrates metabolism disturbance in food is one of the decisive factors of pathogenetic arteriosclerosis and coronary disease. A long balanced diet in particular in fats and carbohydrates favours the normalization of the metabolic processes in stabilization of the organism.

Adult↗
PubMed1984

[Nutrition--a factor in preventing arteriosclerosis, coronary disease and blood coagulation disorders. II. The effect of nutritional imbalance on atherogenesis and the blood coagulation system].

The presented data show that nourishment balanced with respect to fats, carbohydrates, proteins and also containing the necessary vitamins, mineral, salts and microelements is an effective way of prevention and treatment of atherosclerosis and its complications as well as of restoration and preservation of the function of anticoagulative system when its failure is caused by disbalanced food.

Aging↗
PubMed1984

[Antithrombin III activity in long-developing hypercoagulation in animals].

Old rats aged 12-18 months and rats kept on an atherogenic diet for 3.5 months demonstrate high blood antithrombin III content at the initial period of the development of anticoagulation function suppression and of hypercoagulation. During long-developing hypercoagulation, the high content of antithrombin III might be regarded as compensatory reaction interfering with formation in the blood of thrombin microamounts. With hypercoagulation becoming more pronounced and with a further increase of blood thrombin concentration the content of antithrombin III progressively descends, which is accompanied by steady development of anticoagulation function suppression.

Aging↗
PubMed1981

[Distribution of heparin and its complex compounds in the tissues of animals maintained on an atherogenic diet following intravenous administration of a thromboplastin-heparin complex].

After intravenous infusion of the thromboplastin-35- S-heparin complex into rats, maintained on the atherogenic diet within a prolonged period, distribution of the label in the animal tissues and its clearance were studied; total and non-enzymatic fibrinolytic activities were estimated. Inhibition of functions of the anticoagulation system, caused by long-term atherogenic diet in the animals, led to inhibition of the initial steps of heparin clearance as well as to alteration of the glycosaminoglycan distribution in various tissues. At the same time, formation and accumulation of heparin complexes as well as the non-enzymatic fibrinolytic activity were decreased in some tissues.

Animals↗
PubMed1980

[Antithrombin III level on the intravenous injection of tissue thromboplastin and heparin to rats with depressed blood anticoagulating system function due to an atherogenic diet].

Rats with depressed function of the blood anticoagulation system due to an atherogenic diet had a slightly reduced level of antithrombin III by the sixth month of the diet as compared to the indices of control animals. Intravenous injection of tissue thromboplastin revealed delayed and incomplete binding of thrombin by antithrombin III in the experimental animals, which was characterized by only an insignificant decrease in the level of the inhibitor as compared to its change in control animals kept under similar experimental conditions. Preliminary intravenous injection of small doses of heparin into animals with depressed function of the anticoagulation system and low level of heparin in blood stimulates and promotes the binding of thrombin by antithrombin III under conditions of increased thrombinogenesis following intravenous injection of tissue thromboplastin.

Animals↗
PubMed1980

[Epileptic seizures in experimental atherosclerosis].

Case histories of 900 patients suffering from cerebrovascular diseases were analyzed. In 25 of them (2.8%) the disease got complicated with epileptic seizures. In 142 albino rats over 2 years of the age, both "sensitive" and "insensitive" to acoustic stimuli experimental atherosclerosis was induced by their long-time (for 3 to 5 months) keeping on Wilgram's atherogenic diet. As a result of the experiment it has been found that the atherogenic diet was conducive to development of hypercholesterolemia and depression of the blood anticoagulation system. As early as a month after the beginning of the diet application substantial shifts in the function of the central nervous system set in. These shifts were characterized by a shortening of the latent period of the reaction and the seizure and an intensification of the latter. The atherogenic diet led to development of audiogenic seizures in rats formerly insensitive to acoustic stimuli. Transfer of the animals to a cholesterol-free ration resulted in normalization of the blood anticoagulation system in 2 to 3 months. Within the same period the basic indices of the audiogenic reaction got normal, and the intensity of the epileptic seizures decreased.

Adult↗
PubMed1977

[Importance of heparin in thrombin-131I clearance and in the complex formation processes in animals under experimental restoration of the function of the anticoagulating system].

Thrombine-I131 infusion to animals receiving Linethol with vitamin A in the presence of both natural and atherogenic diets accelerated the clearance of thrombine-I131 and elevated the level of nonenzymatic fibrinolysis in the blood and tissue of the liver and lungs. In addition to the administration of thrombine-I131, intravenous heparin injections to animals kept for a long time on atherogenic diets and receiving Linethol with vitamin A provided for a still greater acceleration of thrombine-I131 clearance, which manifested itself in its faster absorption from blood by the liver in the form of a thrombine-I131 -- heparin complex, in an increasing total fibrinolytic activity and of its nonenzymatic fibrinolysis in blood plasma and tissues of the liver and lungs. This resulted in a partial restoration of the function of the anticoagulation system and an increase of the functional activity of the hepatic tissue directed at the consumption of the thrombine excess from the blood flow.

Animals↗