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Biomedical subjects

G Fuglsang

Publications and source records attributed to G Fuglsang.

26 records · Page 2Linked to original sources

Comparison of Nebuhaler and nebulizer treatment of acute severe asthma in children.

In a double-blind, cross-over study, 21 children with acute severe asthma were treated with terbutaline (0.10 mg/kg) delivered by a pressurized aerosol with a 750 ml spacer (Nebuhaler) or as a nebulized solution by a Pari Inhalier Boy. A significant increase in FEV-1 was seen after both treatments. Furthermore, nebuhaler treatment resulted in significantly greater bronchodilation than treatment with the nebulizer (p less than 0.05). Irritation of mouth and throat and coughing were observed in 12 patients during nebuhaler treatment. These problems were not seen when the nebulizer was used. Eleven children preferred treatment with the nebuhaler, whereas only one child preferred the nebulizer. The main reason for preferring the nebuhaler was the shorter administration time.

Acute Disease↗

Absolute bioavailability of terbutaline from a CR-granulate in asthmatic children.

The study aimed at finding the absolute bioavailability of terbutaline of a newly developed CR-granulate. Eight asthmatic children, aged 8-13 years, were given 3 mg of terbutaline as the CR-granulate, concomitant with the intravenous administration of 0.100 mg of deuterium-labelled terbutaline. The labelling of the intravenous dose made possible a separation, in the analytical step, of terbutaline originating from the intravenous and oral administration. Maximal plasma concentration, 8.7 (range: 4.9-15.2) nmol l-1, was reached after 4.7 (2.2-6.0) h. Absolute bioavailability was 10.8 (7.63-16.4) per cent. The parameter values were similar to those found after administration of terbutaline CR-tablets to adults. The CR-formulation is easily swallowed and can be dosed twice daily. Thus it should be a good alternative to elixir or plain tablets, dosed three times a day.

Adolescent↗