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Biomedical subjects

G Frija

Publications and source records attributed to G Frija.

At least 73 records · Page 4Linked to original sources
PubMed1989

Contribution of computed tomography in the aetiology and prognosis of cerebral palsy in children.

Retrospective analysis of computed tomographic (CT) examinations in 76 children with cerebral palsy without any severe intellectual handicap has revealed abnormalities in 63% of these children; abnormalities were present in 88% of former pre-term infants. This study highlights the significant pathogenic role of periventricular leucomalacia in cerebral palsy, since in 45% of the cases of this series this diagnosis had been reached as a result of a characteristic CT appearance associated with a history of premature birth and very specific clinical deficits. The CT abnormalities, mostly posterior and generally bilateral and symmetrical, affect the contours of the lateral ventricles, which become straight and angular, and often involve ventriculomegaly (85%). Localized juxtaventricular hypodensities were only found in a few cases (6%). The cognitive and intellectual sequelae in these children were more severe than in those children whose CT examination was normal, and were also more pronounced when the longitudinal fissure of the cerebrum was enlarged.

Adolescent↗
PubMed1988

Tolerability of hypertonic and isotonic contrast media injected intravenously. A comparative study in the dog.

We examined the use of isotonic and hypertonic contrast media injected intravenously in the dog from the standpoint of cardiovascular tolerance after right atrial injections performed at 2.56 and 5.12 g I/second. The parameters measured were lead II of the electrocardiograph, heart rate, pulmonary and abdominal arterial pressure, and aortic flow. Three contrast media, ioxitalamate, ioxaglate, and iopamidol (two ionic and one nonionic), were compared, either concentrated (32% iodine) or dilute and isotonic with plasma (ioxaglate 160 mg I/mL and iopamidol 128 mg I/mL). At an injection rate of 5.12 g I/second, iopamidol-128 showed lower electrophysiologic tolerability and caused a higher increase in aortic flow than ioxitalamate 160 or ioxaglate 160. These effects may explain the lower radiographic efficacy observed with iopamidol-128 in previous digital subtraction angiography studies.

Angiography↗
PubMed1988

Canine acute myocardial infarction. In vivo detection by MRI with gradient echo technique and contribution of Gd-DOTA.

This experimental study was designed to evaluate the sensitivity of MRI in the detection of acute myocardial infarction, determine the utility of fast gradient-echo (GE) imaging and study possible improvements in diagnostic efficacy using a paramagnetic contrast agent (gadolinium-DOTA). Myocardial infarcts were induced in 11 dogs by semidistal embolization and imaged using spin-echo and/or GE pulse sequences, short TRs (250 to 450 ms) and cardiac gating. After the dogs died, the heart was imaged under the same conditions as in vivo. Blind comparisons between precontrast, postcontrast (0.1 mM/kg and 0.5 mM/kg), postmortem images and anatomic findings (triphenyl-tetrazolium-chloride staining) were recorded. This study shows that infarcted areas can be detected on plain MRI images in the form of a hypersignal, probably attributable to increased proton density, with better efficiency of GE compared with spin-echo imaging; injection of gadolinium-DOTA allows better delineation of infarcted areas, especially for 10 minutes after administration.

Animals↗
PubMed1987

Study of isotonic contrast media in intravenous digital subtraction angiography.

Arterial enhancement obtained with isotonic contrast media in intravenous digital subtraction angiography was studied. Ten dogs were injected with ioxaglate, iopamidol, and ioxitalamate at equal iodine concentration and at concentrations corresponding to plasma osmolality. Three variables were studied: osmolality, injection rate, and iodine dose. Provided their iodine concentration is sufficient, isotonic contrast media appear as efficient as the corresponding hypertonic formulation, at equal iodine dose. Moreover, the use of isotonic ioxaglate allows a lower dose of iodine to be administered without significant reduction in peak arterial value.

Animals↗
PubMed1987

Selective intraarterial DSA of the parathyroid glands in patients with hyperparathyroidism after parathyroidectomy.

Eighteen patients with recurrent hyperparathyroidism after parathyroidectomy were prospectively examined with selective intraarterial digital subtraction angiography (DSA) of the brachiocephalic arteries. The results were compared with findings at reoperation. Seventeen of the 21 remaining abnormal parathyroid glands were correctly detected by selective DSA (sensitivity = 81%). In the neck and mediastinum, sensitivities were 73% (8/11) and 90% (9/10), respectively. All patients with histopathologic confirmation of primary hyperparathyroidism (17/18) became normocalcemic postoperatively. We conclude that selective intraarterial DSA is indicated in patients with recurrent hypercalcemia after parathyroidectomy when the results of noninvasive imaging techniques are uncertain.

Adolescent↗
PubMed1987

[Ultrasonography of subclinical primary testicular tumors. Apropos of a Sertoli cell tumor].

The authors report an original case of an adult presenting with a bilateral Sertoli cell testicular tumour in whom one of the impalpable lesions was detected by routine ultrasonography. This appears to be the first reported description of the ultrasonographic appearance of such a subclinical tumour. The review of 20 published cases reporting the appearance of impalpable primary tumours reveals that in the great majority of cases the echostructure is hypoechoic and therefore does not present any histological specificity, and that these tumours tend to be essentially seminomas or Leydig cell tumours. The indications for scrotal ultrasonography in the detection and follow-up of scrotal tumours are discussed.

Aged↗
PubMed1987

[Magnetic resonance imaging in the diagnosis of soft cervical disk hernia. Evaluation report on 20 cases previously examined by x-ray computed tomography].

Twenty successive patients were examined using CT scanning followed by M.R.I. Thirteen were subsequently operated upon. The results are reported in detail, specifying which signals were used to make the diagnosis of cervical disc prolapse. Short sequences were used for degeneration in the herniated disc, disc protrusion into the spinal canal and compression of the spinal cord. Long sequences were used for indentations or blocks in the cerebro-spinal fluid column at the level of the disc prolapse. Ordinary disc degenerations and associated stenoses are also shown. The reliability of the method was established by comparison with radiographs and surgical findings which were shown to be positive in all the 13 cases treated surgically. The report discusses the difficulties and current limitations of magnetic resonance imaging such as the scarcity of machines, the supine position, the length of the examination, the mediocre quality of horizontal axial sections and difficulties in transmitting magnetic resonance information. There is expected to be rapid and decisive progress with the use of rapid imaging, the preferential choice of sequences, the use of scout views and closer collaboration between radiologist and clinician. A final section is devoted to a discussion of the relative merits of CT scanning and M.R.I. The latter has the advantage of providing total three-dimensional information, particularly in the sagittal plane with a better appreciation of the relationship between container and contents and a method which is strictly non-invasive with the use neither of contrast medium nor X-rays. The authors conclude that M.R.I. provides a positive contribution to the diagnosis of cervical disc protrusions and that this technique can, from now onwards, be considered the examination of choice.

Adult↗
PubMed1986

[Takayasu's disease. Value of digital intravenous angiography. 44 cases].

Forty-four patients with Takayasu's arteritis were explored by digital intravenous angiography either for diagnostic purposes and pre-therapeutic assessment (n = 29) or immediately after surgery (n = 15). There were 36 women, 6 men and 2 children; mean age was 31 years. The contrast medium (mean volume 140 ml) was injected into central (74%) or peripheral (26%) veins. No other angiographic exploration was contemplated in 24 patients selected for medical treatment. Among 15 patients destined to surgery or percutaneous angioplasty, 13 were operated upon without further angiography and 2 underwent arteriography since the distal vascular bed beyond the major lesions could not be evaluated adequately. Data obtained from post-operative evaluation (n = 15) were satisfactory, with 1 failure in this group. Digital intravenous angiography seems to be reliable enough to be used as first examination in patients with suspected Takayasu's arteritis. The procedure is well tolerated and can be repeated for optimum determination of the operation date. Arteriography can now be reserved to those rare cases where digital angiography has failed; it can then be limited to the study of a specific territory, the site of puncture being located by digital angiography.

Adolescent↗
PubMed1986

Primary lung cancer staging: prospective comparative study of MR imaging with CT.

Forty-four patients with bronchogenic carcinoma were studied prospectively by both computed tomography (CT) and magnetic resonance (MR) imaging of the thorax during the week preceding thoracotomy. Transaxial MR imaging sequences included T1- and T2-weighted sequences. Coronal and sagittal T1-weighted sequences were added according to tumor location. CT and MR studies were reviewed separately, and the results were compared with surgical and pathologic findings on the basis of TNM classification. No statistically significant differences were found between the two imaging methods for the evaluation of tumor extent or node involvement. T2-weighted sequences did not yield further information on tumor extent or node involvement. Additional imaging planes (coronal or sagittal) appeared useful to study chest wall invasion. Analysis of concordances and discordances did not indicate whether one modality could be substituted for the other, or which diagnostic strategy might be more useful.

Adenocarcinoma↗
PubMed1986

[Digitized intravenous angiography in Takayasu's disease. Apropos of 44 cases].

Forty-four patients with Takayasu's disease were investigated by digitised intravenous angiography (DIVA) during a diagnostic and pretherapeutic work up (N = 29) or at surgery (N = 15); the aim of this retrospective study was to assess the role of DIVA in the investigation of this condition. The patients were 36 women, 6 men and 2 children; the average age was 31 years. The intravenous injections were performed in a central vein in 74% and in a peripheral vein in 26% of patients; the average amount of contrast medium injected was 140 ml per investigation (32 g of iodine %). Depending on the site of the lesions, the distribution of the 43 successfully investigated patients was as follows: Type I: 13 (20%), Type II: 6 (14%), Type III: 12 (28%), Type IV: 12 (28%). In the group of patients managed medically (N = 14) no other angiographic investigations were considered. In the group with an indication for surgery or percutaneous angioplasty (N = 15), the procedure was carried out without further angiography in 13 cases; in 2 patients the imaging of the distral vessels was inadequate and complementary angiography was required. All postoperative controls (N = 15) but one were satisfactory. These results show that DIVA is sufficiently reliable for it to be considered as an investigation of first intent in patients with suspected Takayasu's disease. The investigation is well tolerated and can be repeated when necessary to determine the optimal time for surgery. Arterial angiography should seem only to be indicated when the venous approach has failed, which was rare in this series.

Adolescent↗
PubMed1986

Intravenous digital subtraction angiography in Takayasu's disease. A report of 32 cases.

IVDSA appears to be a reliable method and should therefore be considered as a first step examination when Takayasu's disease is suspected. The simplicity and safety of the method provide a rationale for the use of this technique in Takayasu's disease. Therapeutic decisions can usually be obtained without further radiological investigation, and conventional arteriography has to be performed only when data obtained with IVDSA are insufficient. In these rare cases, conventional arteriography aims at the investigation of a particular area. The site of arterial puncture can be precisely guided by IVDSA.

Adolescent↗
PubMed1985

[Takayasu's aortitis. Exploration of the aorta and its branches by digital angiography and cross-sectional echography].

In Takayasu's disease full radiological exploration of the arteries requires multiple injections of a contrast medium, and this would be difficult to achieve in the course of one single examination. In the present study, two non-invasive methods--digital angiography and cross-sectional echography--were used comparatively to evaluate arterial lesions in 13 ambulatory patients presenting with this disease. Conventional arteriography had previously been performed in 11 of them. The results obtained with digital angiography were considered satisfactory in 12 patients. All underwent aortic and pulmonary echography. Digital angiography and cross-sectional echography provide full, reliable and non-invasive exploration of the aorta and pulmonary artery. Echography shows abnormal thickness of the vascular walls, but the arterial branches can be explored only by digital angiography. The value of these two non-invasive methods is discussed.

Adult↗
PubMed1985

[Vascular malformations of the digestive tract: a cause of severe digestive hemorrhage. Apropos of 2 cases].

We report on two cases of angiodysplasia of the digestive tract complicated by serious acute bleeding. The preoperative diagnoses were made by angiography. One case concerned a voluminous jejunal lesion which was macroscopically visible; the other concerned a punctiform lesion detected only by angiography and not found on the pathology specimen. The authors insist on the potential gravity of these angiodysplastic lesions, the necessity to perform an emergency celio-mesenteric angiogram when confronted with a serious digestive tract hemorrhage non-explained by conventional methods of exploration when they can be performed.

Adult↗