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Biomedical subjects

G Friedman

Publications and source records attributed to G Friedman.

185 records · Page 11Linked to original sources
PubMedDate not supplied

The effects of estrogen on short-term memory in genetic men.

BACKGROUND: The subject of estrogen in regard to short-term memory is controversial. There is support in the medical literature for estrogen improving short-term memory in women, but there are few data on this subject pertaining to genetic men. OBJECTIVE: To examine the effects of supplemental estrogen on short-term memory in genetic men. DESIGN: A matched control study. SETTING: Private interview rooms. PARTICIPANTS: The variable group consisted of 31 transsexual men taking estrogen to change their gender. The control group comprised 31 age- and education- matched men not taking estrogen. In addition, a group of four subjects not initially taking estrogen was studied immediately before and for a short time after initiating estrogen therapy. MEASUREMENTS: Short-term memory was evaluated by four accepted short-term memory tests dealing with digits, words, and sentences. RESULTS: Three of the four short-term memory tests showed statistical significance favoring the estrogen-treated subjects. The Wechsler Adult Intelligence Scale-Revised Digit Span for Digits Forwards (Test 1) showed a trend toward improvement. The Wechsler Adult Intelligence Scale-Revised Digit Span for Digits Backwards (Test 2), the Woodcock-Johnson Tests of Cognitive Ability Memory for Words (Test 3),Sentences (Test 4) all showed statistical significance. CONCLUSIONS: Results support the hypothesis that estrogen enhances short-term memory in genetic men. This study, in conjunction with others, indicates the possible usefulness of estrogen therapy in the treatment of Alzheimer's disease.

Journal Article↗
PubMedDate not supplied

The effect of acute and chronic administration of nicotine on lipoprotein lipase activity.

Nicotine was injected intraperitoneally to rats and 2 h later lipoprotein lipase was determined in isolated perfused hearts. There was a significant increase in heparin releasable lipoprotein lipase activity which represents the functional pool without increase in total enzyme activity. When 1 microliter/h of a solution of nicotine (120 mg/ml) was delivered for 3 days from subcutaneously implanted miniosmotic pumps, total lipoprotein lipase activity in the heart increased 1.5-3.0 fold. Endogenous lipoprotein lipase activity in plasma doubled and there was a significant fall in plasma triglyceride levels. The effect of nicotine on heart lipoprotein lipase activity was evident also after 6 days of continuous delivery and was accompanied by a fall in adipose tissue lipoprotein lipase activity. No effect was seen when the dose of nicotine was halved. A positive correlation was seen between plasma nicotine levels and heart lipoprotein lipase activity, while adipose tissue lipoprotein lipase correlated negatively with plasma nicotine levels. Chronic administration of nicotine was accompanied by either weight loss or diminished weight gain. It is concluded that in the rat the acute effect of nicotine on the shift of lipoprotein lipase to the functional pool could be related to enhanced beta-adrenergic stimulation. The chronic effect of nicotine could have been mediated by the loss in body weight, due to reduced caloric intake.

Animals↗
PubMedDate not supplied

Temporal arteritis in Israel. A review of 47 patients.

We reviewed the charts of 47 patients with biopsy proven temporal arteritis, hospitalized in 9 major hospitals in Israel. The age of onset and clinical manifestations of this disease in Israel are similar to those reported from other parts of the world. The disease is more frequent (greater than x 3) in Ashkenazi than in Sephardic Jews and only 1 patient was Arab. More than half of the patients (20/32) had laboratory evidence of liver damage reversible with treatment. Follow-up of 19 of these patients revealed that the treatment with corticosteroids was continued in most patients for more than 2 years.

Adrenal Cortex Hormones↗