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Biomedical subjects

G Friedel

Publications and source records attributed to G Friedel.

43 records · Page 3Linked to original sources
PubMed1991

[Conservative surgical techniques in the area of lung surgery].

An important condition for careful operations in lung surgery are modern anesthesia procedures like one-lung ventilation and high-frequency jet ventilation. The aim of careful procedures is the preservation of normal lung tissue. Most commonly broncho- and angioplastic resections are performed to avoid a pneumonectomy without loss of radicality. Minimally invasive endoscopic surgical techniques combined with laser application complete the spectrum of careful procedures in thoracic surgery, e.g., for resection of lung cysts or for thoracic sympathectomy.

Humans↗
PubMed1989

[Functional aspects of pleural empyema and pleural induration].

Decortication for pleural empyema with or without residual cavities was performed in 161 patients. Indications were sanitation of infection sites and improvement of respiratory function. A total of 73.3% of the patients had a non-specific and 22.4% a tuberculous empyema. Postoperative complications included 8.7% wound infections and 1.2% recurring empyema. Operative mortality was 0.6%. To estimate pulmonary function, the preoperative values of blood gas analysis and vital capacity were assessed in 75 patients and compared with those obtained after one year. A relatively slight improvement was seen only in those patients who had a preoperative reduction of vital capacity amounting to more than 40%. An indication for decortication solely to improve pulmonary function is rare. As a rule decortication is indicated for the simultaneous removal of septic foci and functional improvement.

Adult↗
PubMed1984

Cytostatic and cytotoxic response of Ehrlich ascites tumor cells in vivo on chronic treatment with cytarabine, bleomycin, and peplomycin.

The cytokinetic response of Ehrlich ascites tumor (EAT) cells in vivo upon chronic treatment at low dosage levels with cytarabine (1-beta-D-arabinofuranosylcytosine, ara-c) bleomycin (BLM) and peplomycin (PEP) was estimated. Bivariate DNA histograms allow the simultaneous evaluation of the cell cycle status of living and killed cells. It could be confirmed that ara-C is cytostatic on cells in S phase. Pronounced cytotoxicity was observed in G1 and G2+M phase. BLM and PEP showed no (or neglectable ) accumulation of vital cells in any cycle phase. Both drugs, however, are cytotoxic on cells, regardless their position within the cell cycle. A successive application of ara-C and BLM (or PEP) in a cell kinetics-directed therapy schedule may be taken into account.

Animals↗
PubMedDate not supplied

Cystosarcoma phyllodes malignum: a case report of a successive triple modality treatment.

This paper reports on a woman with a rapidly growing recurrent cystosarcoma phyllodes malignum after two major attempts of surgery. In this situation, neoadjuvant hyperfractionated radiotherapy, superficial hyperthermia and ifosfamide were administered. Toxicity was mild. Resection of the tumour bed revealed a pathologically complete response with an actual disease free follow-up of 48 months.

Antineoplastic Agents, Alkylating↗
PubMedDate not supplied

Resection of pulmonary metastases from renal cell carcinoma.

Between 1980 and 1995, 77 patients underwent complete resection of pulmonary metastases from a renal cell carcinoma after exclusion of a primary tumor recurrence and other metastatic localizations. 30-day mortality was 3%. The Median follow-up was 34 months (M). Cumulative 5-year survival (5-YS) was 39%. Prognostic criteria are the duration of the disease-free interval (DFI) and the number of metastases. Patients with a DFI > or = 48 M had a 5-YS of 46% compared to 26% for a DFI of < 48 M. Patients with a solitary metastasis had a 5-YS of 49% compared to 19% for multiple metastases. There was no significant difference in terms of sex, kind of access, kind of operation, and unilateral or bilateral affection. Since metastases from renal cell carcinomas are almost resistant to chemotherapy and radiotherapy and immunotherapy at present does not considerably improve long-term survival, surgical resection currently is the only effective therapeutic access in renal cell cancer metastasized to the lung.

Adult↗
PubMedDate not supplied

Operative thoracoscopy for recurring pneumothorax.

Video-assisted thoracoscopic surgery has markedly changed the management of recurrent pneumothorax. Thoracotomy is no longer the routine approach for the surgical treatment of bullae, partial pleurectomy, or various methods of pleurodesis. Many surgical procedures on the lung and the pleura can be performed endoscopically as safely and easily as in open thoracic surgery. These new techniques have been assessed in 94 patients. An early analysis of the postoperative data shows that the minimally invasive procedure reduces postoperative discomfort and the length of hospital stay; the rate of recurrence is no higher than that for open pneumothorax surgery.

Equipment Design↗