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Biomedical subjects

G Frank

Publications and source records attributed to G Frank.

At least 253 records · Page 14Linked to original sources
PubMed1977

[Implantation of the intraaortic balloon catheter through the aorta ascendens (author's transl)].

In intraoperative cardiac low out-put syndrome balloon implantation through the ascending aorta can be accomplished for secure and rapid installation of IABP, if sternotomy has occurred and successful insertion through the common femoral artery has proven to be impossible. The disadvantage of rethoracotomy for explantation of the balloon catheter can be accepted without additional risk.

Aorta, Abdominal↗
PubMed1977

[Intramyocardial calcification of unknown origin (author's transl)].

A case of intramyocardial calcification is presented. The etiology can neither be explained by history, nor by clinical or histological examination. The diagnosis was made by cardiac catheterization and angiocardiography. This showed that the calcification had occurred mostly in the myocardium of the left ventricle and interventricular septum. Because of chronic heart failure surgery was indicated and large amounts of the calcified mass were removed by means of an open heart operation. One and a half years later the patient is much improved though clinical signs of heart failure persist. Possible causes of myocardial calcification are discussed and the problems of surgical intervention outlined.

Adult↗
PubMed1977

[Intracardiac correction of congenital heart anomalies in 104 infants (author's transl)].

From 1974 to 1976 104 infants (under 1 year of age) underwent intracardiac correction for congenital heart diseases. Mean age and body weight were 6.6 +/- 3.6 months resp. 5.66 +/- 1.4 kgs. The diagnoses and mortality rates were: transposition of the great arteries (TGA) with intact ventricular septum 27 (0), TGA plus associated anomalies 9 (0), ventricular septal defect (VSD) 20 (1), VSD plus associated anomalies 6 (1), total anomalous pulmonary venous drainage 9 (5), pulmonary stenosis and pulmonary atresia with intact ventricular septum 9 (2), aortic stenosis 7 (3), ASD I or II 7 (0), and miscellaneous 10 (3). Intracardiac correction was performed either on cardiopulmonary bypass and moderate hypothermia or in deep hypothermia with or without total circulatory arrest. The early mortality in the first group was 7% (6 out of 90), in the second group 64% (9 out of 14). With increasing experience, cardiopulmonary bypass has proven to be a save method for intracardiac correction of congenital heart anomalies in infancy even in the youngest age group under three months of age and under emergency conditions.

Age Factors↗
PubMed1977

On validity of hypotheses derived from the rorschach: II. interpretation of card IV as "father" card and card VII as "mother" card.

Research testing the validity of the hypothesis that Card IV of the Rorschach can be viewed as the "father" card and Card VII, the "mother" card was reviewed. Essentially the research suggests that such symbolic interpretation of the Rorschach stimuli is most characteristic of children and in particular emotionally disturbed children, but not adults, either normal or schizophrenic. The assumption that Cards IV and VII have universal symbolic meaning was, thus, called into question. A critical analysis of the research stratagems used in testing this hypothesis was offered and some suggestions made for future research.

Adult↗
PubMed1976

[Clinical observations on the psychopathology of amnesic episodes (transient global amnesia) (author's transl)].

Observations obtained by psychopathologic examination and some psychologic testing of two patients in the course of amnesic episodes (transient global amnesia) are presented and discussed. In both cases the psychopathologic findings are those of a reversible isolated amnesic syndrome, characterized by diffuse retrograde amnesia and recent memory deficit, whereas immediate and remote (personal) memory are preserved. Stereotype questions, disorientation in time, and--in one case--anxious restlessness, which accompany the amnesic syndrome, are probably due to impaired memory and the patient's awareness of it. This typical syndrome allows differentiation of amnesic episodes from other types of amnesia. In the first case, which had been under clinical observation from the beginning to the end of the amnesic episode, a special evolution of the event could be ascertained. The acute amnesic episode reached its climax with a certain delay and thereafter decreased gradually. It can be presumed that--at least during the remission phase in the second case--the ability of recall is impaired rather than that of registration and retention. Other findings obtained in the second case--and compared with observations in the literature--point out that in the phase of remission the timespan of retrieval seems to become longer and, in respect to previously applied sensory modalities, improves in a different manner.

Aged↗
PubMed1976

[Neurological and psychiatric disorders following acute arsine poisoning (author's transl)].

Follow-up study of 6 workers, who after survival of an acute arsine poisoning, developed psychopathologic and neurologic abnormalities. The symptoms appeared after a latency of 1 to 6 months indicating a toxic polyneuropathy and a mild psycho-organic syndrome. The severity of these reversible manifestations was directly related to the period of time of exposure to arsine. The clinical picture of arsine polyneuropathy was similar to that observed in arsenic poisoning, suggesting that arsine polyneuropathy is due to the action of arsenic. The psychopathologic syndrome corresponds to the so-called "Vergiftungsspätfolgesyndrom" and therefore does not appear to be a specific sequel of arsine poisoning.

Adult↗
PubMed1976

[Chronic pernicious course in multiple sclerosis with involvement of the optic nerves and total spinal sclerosis (diffuse spinal sclerosis) (author's transl)].

Four cases with the clinical diagnosis of chronic MS are presented, which, histologically, show large solitary demyelinated and gliotic areas involving almost the entire spinal cord over 12-25 segments as well as the optic chiasm. The abortive form of the neuromyelitis optical syndrome in MS is discussed. The additional involvement of the cerebral hemispheres suggests that the clinical and histological picture described is related to Schilder's disease.

Adult↗
PubMed1976

Thermophilic and mesophilic enzymes from B. caldotenax and B. stearothermophilus: properties, relationships and formation.

1) The adaptive system of thermophilic bacteria, as demonstrated with B. caldotenax, seems to be suitable to produce thermophilic and mesophilic enzymes for comparative studies. 2) If it may be assumed that the extensive homologies in the N-terminal sequences of the LDHs also extend over the entire polypeptide chain, comparison of these sequences together with investigation on the 3-dimensional structure offer the possibility of elucidating those structural details which may be responsible for thermostability and the other thermophilic properties. However, the difficulty still remains that the latter may be obscured by differences not related to thermostability etc. Neverthless it may be hoped that comparison of the full sequences of not only the LDHs but also of a sufficient number of other enzymes of the same system will yield such details. 3) A further interesting goal with respect to the mechanism of enzyme adaptation would be reached if the differences in amino acid sequence of thermophilic and mesophilic LDH enzymes would throw light on the type of the amino acids always being exchanged. Here from the very hypothetical point of view the question arises as to whether the bacterial cell during the metabolic adaptation process or even by mutation/selection is able to modify just those few amino acid residues thermodynamically important for thermostability. Alternatively: does there exist a "rule" by which certain amino acid residues are invariably exchanged on a change for thermophilic to mesophilic enzymes? 4) Problems not mentioned here arise with B. stearothermophilus, which can be adapted poorly via the spores or on intermediate temperatures. Of great importance, but also a special problem in these studies on thermophilic and mesophilic enzymes produced by the same bacterium are a) the characterization of the thermophilic (70 degrees or 55 degrees) and mesophilic (37 degrees) bacterial variants (in respect to type), b) the control of homogeneity of the bacterial culture (contamination, mixed population), c) proof of the genetic identity of the 70 degrees- (55 degrees-) and 37 degrees -variant of B. caldotenax and B. stearothermophilus, which differ greatly in their phenotypes, for example in their metabolism, cell- or colony merphology. The taxonomical-biochemical identity or also the identity of morphology of the sporangia, since this should be an expression of the temperature dependent phenotype, cannot be used unconditionally as criteria of identity. Criteria such as the presence of identical enzymes in both variants or the identity of the genome (use of genetic markers, anlaysis of the DNA) are more reliable. Experiments with both variants of B. caldotenax demonstrated an identically high content of cytosine plus guanine in their DNA: 62.2% in the thermophilic DNA and 66.8% in the mesophilic DNA. In the thermophilic B. stearothermophilus the C+G content of the DNA was 56.5% and in the mesophilic variant 57.1%...

Adaptation, Physiological↗
PubMed1976

Residual effects when chronic propranolol therapy is discontinued within 48 hours of cardiopulmonary bypass.

Recommendations regarding the safe waiting period between discontinuing chronic oral propranolol therapy and beginning cardiopulmonary bypass have varied from a few hours to 2 weeks. In the present study, utilizing adult dogs, propranolol was discontinued 8 or 48 hours prior to surgery. A reduction in cardiac output and elevations of left ventricular end-diastolic pressure, peak systolic pressure, and systemic resistance were noted when cardiac function was evaluated following the induction of anesthesia and prior to undertaking cardiopulmonary bypass. The magnitude of these differences was directly related to the degree of volume loading and inversely related to the interval between the last dose of propranol and the determination of cardiac function. Reduction of heart rate was the most evanescent of propranolol's hemodynamic effects as the marked bradycardia which persisted throughout the course of propranolol therapy was no longer evident 8 hours after the last oral dose of the drug. Following total cardiopulmonary bypass of 1 hour's duration, undertaken 8 hours after the last oral dose of propranolol, cardiac output and left ventricular end-diastolic pressure had returned to normal but peak systolic pressure and systemic resistance remained significantly elevated, When 48 hours had elapsed between discontinuing propranolol and beginning cardiopulmonary bypass, postbypass cardiac function was essentially normal with only slight persistent elevations of peak systolic pressure and systemic resistance detected. When the combined effects of ischemic heart disease and propranolol therapy, the altered metabolic and hemodynamic effects of different routes of drug administration, and the varying durations of cardiopulmonary bypass are taken into consideration, some of the discrepancies between previously reported clinical and experimental findings regarding the duration of persistent propranolol effects can be understood. The clinical course is usually benign in patients who have received propranolol to within a few hours of surgery without specific indication. However, it is often complicated when the drug is continued until just prior to surgery in patients dependant on propranolol for pain or arrhythmia control. In patients demonstrating propranolol dependence, control of symptoms with intra-aortic balloon counterpulsation is recommended followed by the gradual withdrawal of propranolol and elective aortocoronary bypass surgery.

Administration, Oral↗
PubMed1976

The complete amino acid sequences of both subunits of the sweet protein monellin.

The amino acid sequences of both chains of the sweet protein Monellin have been determined. Since chain separation could not be accomplished easily, cyanogen bromide cleavage at the only methionine residue (in the B-chain) was performed and the three products obtained after cyanogen bromide cleavage were separated. For the identification of amino acid phenylthiohydantoins, high performance liquid chromatography was employed. Thus 37 out of a total of 44 residues of the A chain and 40 out of a total of 42 residues of the large CNBr fragment of the B chain could be determined after Edman degradation of the polypeptides on an automated sequenator.

Amino Acid Sequence↗
PubMed1976

On the validity of hypotheses derived from the Rorschach: 1. The relationship between color and affect.

Interpretation of response to color on the Rorschach rests on Rorschach's assertion that color has affective connotations. His assumption was based on the connection of color and affect in culture and as regards the differential response to color by patients he tested. This review focused on research which could lend support to Rorschach's empirically derived notion. Ignoring clinical studies of psychiatric patients (in the absence of any theory of affects unique to specific psychiatric groups), this review focuses primarily on psychological tests of the hypothesis. Affect does seem to be associated with colors but not so specifically as to be useful in interpreting the meaning of the response by any one person. Moreover, affect was seen to affect the many dimensions of the Rorschach stimuli. Interpretation of the response to color must take into account the unsystematic way in which factors influence response to color on the Rorschach, e.g. saturation, context, area covered, etc, vary from card to card. These factors alone influence the response to color and make it impossible to draw conclusions using the plates as constructed. The interpretation of affect from response to color on the Rorschach was seriously questioned.

Affect↗
PubMed1976

[Amnestic episodes in migraine. A contribution to the differential diagnosis of transient global amnesia (ictus amnésique)].

In comparison with 27 similar cases, sampled from literature, 4 observations of amnesic episodes in migraine are presented and discussed. These disturbances known as so-called "Migranedammerattacken" seem to be identical with transient global amnesia in all respects. In most of cases, they occur as migraine-precursors or - equivalents. Headache, vegetative und neurological symptoms are frequent but not necessary companions. It is proposed to look for migraine disposition in all cases of transient global amnesia. Perhaps, this approach might be of some use to understand their enigmatic pathogenesis.

Aged↗