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Biomedical subjects

G Francois

Publications and source records attributed to G Francois.

At least 37 records · Page 2Linked to original sources
PubMed1984

The early period of experimental Mendelson's syndrome in dogs with PaCO2 and pH in a normal range.

In 9 dogs the first 240 min of experimental Mendelson's syndrome were studied. To minimise hemodynamic alterations, the PaCO2 and pH were kept within the normal range. An increase in pulmonary artery pressure, Qs/Qt and a decrease in PaO2 were demonstrated. Diminution of heart rate and cardiac index were associated with the decrease of systemic oxygen transport. The first 30 min appeared as a para-sympathetic syndrome, the remainder of the experiment as a hypovolemic syndrome. Severe hypoxia was observed during the two periods.

Animals↗
PubMed1984

Effect of leucine or ketoleucine on nitrogen metabolism in postoperative patients receiving energy substrate.

It has been shown that ketoisocaproate (KIC) spares nitrogen (N) in fasting postoperative patients while leucine does not. The aim of the present study was to determine if KIC when compared with leucine, decreases nitrogen excretion in postoperative patients receiving energy substrate. Thirty patients undergoing gynecological surgery (hysterectomy with or without lymphadenectomy) were randomized to receive for the first 3 postoperative days one of the following I.V. solutions per kilo and per day: 3 g glucose (group A) 3 g glucose + 90 mg Leucine (group B), 3 g glucose + 100 mg ketoleucine (group C). The output of 3 methylhistidine (3 MEH), total nitrogen and creatinine were measured daily. Although muscle protein breakdown measured as 3 MEH/creatinine molar ratio was significantly reduced in group C as compared with A and B, total nitrogen and creatinine did not differ significantly in A, B and C. Thus, the metabolic effects of KIC in postoperative patients are appreciably influenced by glucose infusions and the usefulness of KIC infusions in such patients needs further study.

Journal Article↗
PubMed1984

Fluosol 43 intravascular persistence in mice measured by 19F nmr.

Quantitative determination of the intravascular persistence of F-tri-n-butylamine (FC 43 as Fluosol 43) in mice was carried out using 19F nmr spectroscopy. The method allows the direct study of whole blood, neither separation nor extraction of the sample being required. Accuracy (reproducibility) is better than +/- 3%, and is comparable to that of the gas chromatographic (gc) method. The sensitivity of detection is less than that of the gc method but is sufficient for this biological study. It was observed that the intravascular elimination of F-tri-n-butylamine follows a non-linear kinetic and becomes faster about 40 h after the injection. This phenomenon may be explained by the size-increase of the FC 43 droplets in the emulsion. Indeed, at about 40 h after injection, the level of Pluronic F-68 in the bloodstream was no longer sufficient to maintain the stability of the FC-43 droplets. They therefore tended to coalesce forming larger droplets that were phagocytosed more rapidly by the histiocytes of the reticuloendothelial system.

Animals↗
PubMed1976

[Do enzyme determinations have any prognostic value in neurotraumatology?].

In 34 cases of skull traumas and in 14 cases of acute cerebral accidents, CK, GOT, GPT, LDH and its isoenzymes were assessed in the patient's serum and CSF. Results show that the increase of the enzymatic level in the CSF seems due to cerebral tissue damage for the main part, when in the serum the increase is influenced by combined traumas. The CSF dosages allow to define a threshold of severeness, unlike serum dosages without any pronostic value.

Alanine Transaminase↗
PubMed1976

[Hemostatic disorders in septicemia. Apropos of 65 cases].

In the course of a restrospective study, some hemostatic parameters were studied in connection with 65 cases of septicaemia. From this study, it follows that coagulation troubles are more frequent in septicaemiae induced by negative Gram germs, but that this frequency is actually linked with circulatory troubles. Besides, as for the biological diagnosis of the disseminated intravascular coagulation syndrome in this instance, it is not possible to take strictly into account the fibrinogen values or the rate of thrombocytes.

Blood Coagulation Disorders↗
PubMed1975

[Nutrition in the surgical patient with complications].

Parenteral feeding in complicated abdominal surgery has been a definite therapeutic progress. However the authors emphasize the divergent attitudes concerning the amounts of nitrogen which should be supplied as well as the variations in the calories-nitrogen ratio. They propose a practical attitude which must be reevaluated individually.

Abdomen↗
PubMed1975

[Pulmonary edemas due to acute heroin poisoning].

Their frequency is estimated with difficulty, although on autopsy pulmonary edema is found almost routinely. It is a major complication of overdoses (48 p. 100 of severe intoxications). Their formation can be suspected, when after the first phase of respiratory depressions, with coma, myosis, and a variable latent period, a second attack of respiratory insufficiency occurs with tachypnea, and cyanosis. The chest X-ray shows diffuse alveolar infiltration, sparing the apices. The heart being generally of normal size. Rapid disappearance of this infiltrate (24 to 48 hours) enables the elimination of two diagnoses: pneumonia due to inhalation of gastric fluid, an infectious pneumonia. Their pathogenesis remains very debatable: - in the majority of cases abrupt L.V.F. can be eliminated: -on the other hand it could be an allergic accident of the anaphylactic type, or local liberation of histamine, or a local toxic action on the pulmonary capillaries; - hypoxia, secondary to respiratory depression, could lead to pulmonary edema, by the same mechanism as at altitude; - finally, owing to the central neurological disorders a neurogenic theory can be put forward. Their treatment is essentially a combination of Nalorphine with oxygen therapy (by mask, or if necessary by assisted, controlled ventilation) with prevention of inhalation of gastric fluid (gastric emptying) or curative treatment of possible aspiration by antibiotics, and cortico-steroids. Diuretics can be useful, as well as cardiotonics.

Acute Disease↗
PubMedDate not supplied

Surgical management of parapharyngeal cystic hygroma causing sudden airway obstruction.

Parapharyngeal cystic hygroma is a rare tumor of the neck. This report describes two cases in which surgical resection was necessary to overcome sudden airway obstruction and details the surgical technique. These cases were considered "near misses" for sudden infant death syndrome (SIDS) and were revealed by computed tomography (CT) and echography to be parapharyngeal cystic hygroma. The location of this malformation could have produced sudden airway collapse and be erroneously diagnosed as SIDS. The postoperative follow-up was satisfactory and no recurrence was detected. We believe CT and echography should be included in the evaluation of such cases.

Airway Obstruction↗