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Biomedical subjects

G Forzy

Publications and source records attributed to G Forzy.

At least 55 records · Page 3Linked to original sources

[Infectious endocarditis caused by rare germs. Review of the literature apropos of 2 cases].

The authors report two new cases of endocarditis secondary to exceptionnally encountered germs: one to Pasteurella pneumotropica, the other ascribed to Leptospira ictero-haemorragiae, on serologic criteria. Concerning these two cases, they propose to take a census of rare germs, from a detailed study of the literature. Among more than 5,000 cases of endocarditis published after 1944, are considered as rare germs those causing a disease in less than one p. cent of the cases. This purely "mathematical" definition enable to include 45 germs. A synthesis of all the cases reported attempts to demonstrate a few particular traits of these endocardites secondary to rare germs.

Adult↗

Unconjugated pteridines in amniotic fluid during gestation.

Neopterin and biopterin concentrations were measured in amniotic fluid in 226 pregnancies from the 12th week of gestation to term. At mid-gestation, neopterin and biopterin levels were low and remained relatively constant between 12 and 26 weeks of gestation, whereas during the third trimester, a progressive increase was observed. Near term the values were greater than those in maternal serum and the higher neopterin to biopterin ratio suggested that pteridine concentration in amniotic fluid may reflect the maturation of pteridine metabolism in the fetus.

Amniotic Fluid↗

[Hormonal changes during relaxation].

Among 10 subjects who practiced autogenic training (AT) and 10 subjects who practiced transcendental meditation (TM), compared to 10 control subjects during 40 minutes, have been observed the following results: --decrease in cortisol plasma level (reaching a minima of 2 g/100 ml), --decrease in prolactin plasma level, --the basal plasma level of cortisol and prolactin were significantly lower in the TM group. Lastly, the urinary catecholamines (UC) increase after 40 minutes of rest in the control group, whereas the UC decrease in the TA group and most certainly in the TM group. All these variations indicate a humoral modification which seems to be the opposite of the state induced by stress.

Adult↗

[Cannabis and nifluril].

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Anti-Inflammatory Agents, Non-Steroidal↗

[Usual values for 5-hydroxy-indol acetic acid and homovanillic acid in cerebrospinal fluid].

The aim of this work was to reinvestiagte usual values of neurotransmitter catabolites (5-HIAA and HVA) in CSF, their determination being a current method for studying pathological processes and/or drug induced changes on CNS metabolism. 5-HIAA and HVA have been measured by reverse phase HPLC and electrochemical detection. Since many confounding factors have been identified to modify the concentration of both analytes in CSF, data from 1.480 patients have been revisited with strict exclusion and 323 have been selected. Age dependent variation and asymetric distributions were observed. Age-related usual values ranges were established after identification of outliers by non-parametric analysis. In a group of patients for which repeated CSF collection have been performed for the follow up of acute leukemia, wide and unpredictible individual variations (up to 400 %) of CSF 5-HIAA and HVA concentrations have been observed. These large interindividual and individual variations may explain the numerous discrepancies found in studies investigating the CNS monoamine metabolism, especially when small groups of patients are used. Such observation limits the interpretation of monoamine metabolic for diagnostic purposes without a strict selection of indication.

Adolescent↗

[Use of formulas for calculating serum osmolality].

Osmolality can be measured or calculated. More than ten formulas have been proposed for calculating serum osmolality from chemical concentrations. The aim of this work was to compare results obtained whith some of these formulas, those calculated in the laboratory using a multiple regression model and measurements with an osmometer. Scattered results for natremia and chloremia, depending on the automate, led us to define formulas adapted for each measurement system in order to reduce the risk of error in the evaluation of the " osmolar gap ".

Blood Chemical Analysis↗

[Correlations between delayed auditory evoked potentials and clinical evaluation of schizophrenic symptoms].

Late auditory evoked potentials (AEPs) were recorded by the "odd-ball" method in 20 schizophrenic patients according to DSM III R diagnosis criteria compared with 30 control subjects matched for sex and age. Patients were on antipsychotic medications; mean duration of illness was 3, 55 years. We have also proceeded to a clinical quantitative assessment of negative and positive symptoms of schizophrenia with Andreasen's rating scales. In the group of patients, we have observed a significant lengthening of the latency of N 1, N 2, P 3, N 3 and a decreased amplitude of N 1 and P 3. These results are in favour of an impairment of cerebral information processing probably localized in the subcortical level. Statistically significant correlations have been noticed between the anomalies of the last stages of information processing (P 3, N 3) and negative symptoms, more particularly affective flattening and attentional impairment. The disturbances of the first stages of information processing (P 2) and of automatic information processing (N 2) were related to positive symptoms, hallucinations and delusions especially. The anomalies of N 2 were also related to the sum of the global scores: an attentional impairment could be a main factor in the determinism of schizophrenia.

Adult↗

[Evaluation of the effectiveness of serotonin (fluoxetine hydrochloride) treatment. Open study in fibromyalgia].

Primary fibromyalgia may involve an anomaly in the metabolism of serotonin responsible for the sleep disorders and diffuse pain. Effectiveness of an agent with pure serotonin-agonist properties (fluoxetin hydrochloride) was evaluated in 23 patients during a three-month open study. Treatment had no effect on pain severity, number of tender sites, or pain score. Sleep disorders improved and 57% of patients believed the treatment was effective. Adverse events were recorded in 43.4% of patients, with the most common being nausea (21.7%). Effectiveness and tolerance of fluoxetin hydrochloride in fibromyalgia are mediocre. A double-blind placebo-controlled trail versus a placebo is needed to clarify these preliminary findings.

Drug Evaluation↗

[Proposed reference values for nine methods for measurement of free thyroxin].

In connection with a comparative study of nine kits for the measurement of free thyroxin, we determined reference values in a adult control group of 81 women and 73 men. The correlations observed between the kits are associated with very large differences in the results obtained. The reference ranges are more or less broad according to the kits, but narrower than those offered by the manufacturers.

Adolescent↗