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Biomedical subjects

G Fleisher

Publications and source records attributed to G Fleisher.

61 records · Page 4Linked to original sources
PubMed1979

Primary infection with Epstein-Barr virus in infants in the United States: clinical and serologic observations.

Previous studies in Ghana had shown that primary infections with Epstein-Barr virus in infants under the age of two years remain silent and evoke antibody responses different from those seen in infectious mononucleosis. In order to determine whether or not these observations were limited to Africa, 80 American infants presenting with minor infectious complaints were studied serologically; 14 (17.5%) showed evidence of recent or current primary infections with Epstein-Barr virus. The clinical features of these 14 infants were similar to those of the other 66 and did not suggest a diagnosis of infectious mononucleosis, nor were there histories of a recent infectious mononucleosis-like illness. Ten (72%) had antibodies to the early antigen complex induced by Epstein-Barr virus; however, these antibodies were directed, as in the Ghanaian infants, against the restricted rather than the diffuse components, in contrast to the pattern generally observed in infectious mononucleosis. Possible reasons for the differences between the responses of infants and those of older individuals to primary infection with Epstein-Barr virus and to the early antigen complex are discussed.

Antigens, Viral↗
PubMedDate not supplied

Infectious mononucleosis during gestation: report of three women and their infants studied prospectively.

Epstein-Barr virus (EBV) infection during gestation has been associated retrospectively with the occurrence of fetal malformations. The referral in the first trimester of three women with infectious mononucleosis allowed us to study prospectively this question. Infectious mononucleosis was confirmed by EBV-specific serology in two women and on the basis of the heterophil antibody response and atypical lymphocytosis in the third. The titers of EBV-specific antibodies in the cord sera of the infants approximated those of the respective maternal sera drawn at the time of birth and declined in a fashion consistent with transplacental acquisition. All three women delivered healthy term infants without malformations or stigmata of congenital infection. Thus we observed no adverse effect of maternal EBV infection on these infants.

Adult↗