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Biomedical subjects

G Flandrin

Publications and source records attributed to G Flandrin.

At least 199 records · Page 11Linked to original sources
PubMed1980

[Acute monoblastic leukaemia. Clinical data and therapeutic results in 74 patients (author's transl)].

Seventy-four patients with acute pure monoblastic leukaemia treated between 1970 and 1978 were studied retrospectively. The disease was usually hyperleucocytic and tumoral in character. It occurred with equal frequency in subjects of both sexes and at all ages, with peaks at the two extremes of life. Rubidazone gave a high percentage (75%) of complete remissions, but the prognosis remained sombre, with a mean survival time of 200 days. The incidence of meningeal relapses was reduced by prophylactic measures at central nervous system level, but gingival and cutaneous relapses were frequent. The possibility of bettering the present modest therapeutic results by more intensive chemotherapy is discussed.

Adolescent↗
PubMed1980

[Acute myeloblastic leukaemia in the course of non-Hodgkin's lymphoma (author's transl)].

Five cases of acute myeloblastic leukaemia (AML) arising in the course of non-Hodgkin's lymphoma (NHL) are described. The initial lymphoma was nodular lymphoid poorly differentiated in 4 cases. All patients were under chemotherapy for at least 28 months, and 3 of them were irradiated. AML was diagnosed 44 to 78 months after NHL and was heralded in 3 cases by a preleukaemia phase of pancytopenia. The leukaemia was typically myeloblastic in 2 cases and difficult to classify in 3 cases. Death occurred rapidly in 4 patients. The actuarial risk was 4.5% at 5 years. Since AML's occur mainly in NHL's, the management of this type of lymphoma with favourable prognosis ought to be reevaluated.

Acute Disease↗
PubMed1980

[Myeloma together with acute myeloblastic leukaemia in an untreated patient (author's transl)].

In a 66-year old man without previous major disease the unexpected finding of pancytopenia on routine blood count during an acute respiratory infection led to the diagnosis of IgG-producing myeloma without radiological bone lesions, associated with partial blastocytosis and abnormalities in granulocyte maturation. No treatment was given. Within 15 days, the circulating blastocytes became more numerous and type M1 acute myeloblastic leukaemia was diagnosed. A combined rubidazone and cytosine arabinoside treatment failed, and the patient died rapidly.

Aged↗
PubMed1980

Phenotypic changes of phytohaemagglutinin-stimulated hairy cells.

Hairy cell leukaemia (leukaemic reticuloendotheliosis) appears to be a homogeneous and well defined disease on the basis of clinical presentation, light and electron microscopic features and cytochemical characteristics, but the study of immunological markers of hairy cells (HC) from many patients reveals apparent heterogeneity. The most common phenotype associates B-cell and monocytic properties: HC usually express monoclonal surface (and in certain cases cytoplasmic) immunoglobulins, receptors for IgM and IgG Fc, and mouse erythrocytes, and la-like antigens. Additionally, they are capable of phagocytosis, glass adherence, lysozyme and peroxidase synthesis. However, most of these features are not constant and cases have been reported in which HC fail to express one or more of these properties. In certain cases HC even display a T-cell phenotype, while, in others, features of both T and B cells are expressed. Moreover, in two recently studied patients, the phenotype of HC in the blood differed from that in the spleen (B + T in the blood and B in the spleen). These surprising discrepancies led us to hypothesize that HC from the same individual might be able to express different phenotypes following an appropriate stimulus. We therefore studied immunological parameters of HC stimulated by mitogens and the results indeed showed that after stimulation by phytohaemagglutinin (PHA) the cells switched from B to T or B + T phenotypes.

B-Lymphocytes↗
PubMed1980

[Abscence of chromosomes abnormalities and acute leukemia : relationships with normal bone marrow cells].

The absence of chromosome abnormalities in 50% of human acute leukemias stress the significance of cytogenetic abnormalities in malignancies. Karyotypically normal cells from acute leukemias were shown to be non leukemic cells by cytological and cytogenetic comparisons. Chromosomally normal acute promyelocytic leukemias could be explained by differences between proliferation rates of bone marrow cells and by bias when choosing metaphases to be analysed. The role of chromosomal abnormalities in acute leukemia must be therefore questioned from a new definition of cytogenetic methods.

Acute Disease↗
PubMed1980

Phagocytosis of neutrophil polymorphonuclears by macrophages in human bone marrow: importance in granulopoiesis.

The cytological and electron-microscopic appearance of aneutrophil phagocytosis by macrophages in normal human bone marrow is described. This feature can be observed in every normal bone marrow and is especially frequent in autoimmune disease. Bone marrrow phagocytosis of polymorphonuclear neutrophils seems to be a physiological process resulting from the random egress of neutrophils from bone marrow to blood.

Bone Marrow↗
PubMed1980

Burkitt's lymphoma occurring 6 years after Hodgkin's disease.

The occurrence of Burkitt's lymphoma (BL) following Hodgkin's disease (HD) has not yet been reported. A patient treated for HD by chemotherapy-radiotherapy association developed a BL 6 years later: it was demonstrated by cytological, cytochemical, immunological and cytogenetical--translocation t (8; 14)--characteristics. Our hypothesis is that, in this case, BL may be the consequences of chemotherapy-radiotherapy association.

Adult↗
PubMed1980

Acute monoblastic leukemia: a clinical and biologic study of 74 cases.

Seventy-four cases of pure acute monoblastic leukemia (AMol) have been retrospectively studied. All patients were treated at Hospital Saint-Louis between 1970 and 1978. Diagnosis was based on morphological and cytochemical features according to the FAB classification. This type of leukemia occurred at any age and in both sexes, with a high frequency of extramedullary involvements. Hyperleukocytosis was very frequent and was significantly correlated with increased blood and urine levels of lysozyme, with renal failure and hypokalemia, and with coagulation abnormalities. AMol still has a poor prognosis, despite a best remission rate (75%) obtained with rubidazone, since the duration of complete remission was short. Central nervous irradiation prolonged remission and prevented meningeal relapses, while 6 meningeal relapses occurred in the patients not irradiated. The high frequency of the extramedullary relapses, including gum and skin, emphasized the question of persistant blast cell sanctuaries after achievement of bone marrow remissions. A more intensive induction with several drugs active against monoblasts could be more efficient and prolong the duration of complete remissions.

Adolescent↗
PubMed1980

Presence of NCA (nonspecific cross-reacting antigen) in the cells of the human granulocyte series.

The presence of NCA (nonspecific cross-reacting antigen) in the cells of the human granulocyte series was investigated by using the immunoperoxidase technique. NCA was detected in normal bone marrow at the promyelocyte stage. It was found in leukemic myeloblasts only when they had some degree of differentiation (M2 type), but the results for promyelocytic leukemias (M3 type) were always negative. Auer rods were never stained by anti-NCA serum. In chronic myeloid leukemias, many pathologic myelocytes were positive, their intensity varying from one case to another; a relation was noted between the intensity of this reaction and the number of neutrophil granules stained by Giemsa reagent on parallel slides of the same cases. Normal-looking polymorphs were often weakly labeled or not labeled by anti-NCA serum in the bone marrow or blood of leukemic patients. Here again, a parallel was seen with the staining of neutrophil granules by Giemsa. From these data, an association between NCA and azurophilic granules can be deduced.

Antigens↗
PubMed1979

[Bone lesions in hairy cell leukaemia (author's transl)].

Between 1959 and 1978, 150 patients with tricholeucocytic leukaemia were seen, 5 having radiological bone lesions. This has been reported only once in the literature, its significance and therapeutic consequences remaining ill-defined. One of the commonest sites of bone involvement is the neck of the femur. The usual appearances are those of demineralisation, lysis and pathological fracture. The true prevalence of such lesions could be determined only by routine studies for the presence of such lesions.

Adult↗
PubMed1979

[A new variety of acute non-promyelocytic leukemia with t(15;17)].

Three cases of a new variety of acute leukemia have been reported. The main features were: hyperleukocytosis made of large-sized blasts with a double shaped nucleus, few or no granulations in the cytoplasm, and in a few cell faggots or unique Auer rods; mycloperoxydase reaction was positive. This feature was associated with disseminated intravascular coagulation syndrome and t(15;17)(q22;q21) translocation in the majority of mitoses.

Acute Disease↗