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Biomedical subjects

G Fink

Publications and source records attributed to G Fink.

At least 325 records · Page 18Linked to original sources
PubMed1967

Demonstration of luteinizing hormone releasing factor in hypophysial portal blood of pro-oestrous & hypophysectomized rats.

1. A method for the routine collection of hypophysial portal blood from rats under direct vision has been described.2. This method has been used to obtain portal blood from adult female rats in pro-oestrus and adult female rats which had been hypophysectomized at least 14 days before collection.3. The pooled plasma from this blood was assayed for activity, resembling that of luteinizing hormone releasing factor (LRF), by the ovarian ascorbic acid depletion method.4. The portal plasma from both groups of donor animals exhibited significant activity when compared to peripheral plasma controls.5. It is concluded that the ovarian ascorbic acid depleting activity of portal plasma was due to LRF.6. The possibility that some of the activity exhibited by portal plasma from pro-oestrous rats was due to contamination of the samples by LH containing backflow blood from pituitary sinusoids is discussed.7. The possibility that the ovarian ascorbic acid depleting activity of the hypophysial portal plasma was due to either vasopressin or a nonspecific factor has been excluded.

Animals↗
PubMedDate not supplied

Mood, cognition and cortisol: their temporal relationships during recovery from depressive illness.

Single-case methodology, using cross-lagged panel correlations, was applied to study the order of change in mood, cognition and cortisol concentration in eight in-patients with a diagnosis of major, endogenous depression. Daily measures included: two visual analogue scales measuring depressed mood and general feeling of unwellness; cortisol concentration in saliva (sampled four times a day) and in 24-h urine; two cognitive scales, the Automatic Thoughts Questionnaire and the Cognitive Style Test. The results relating to the temporal relationship between biological and psychological data were ambiguous as the pattern of change was inconsistent among individuals. Group data indicated that changes in feeling unwell preceded changes in early evening salivary cortisol and changes in negative automatic thoughts preceded changes in day and early evening salivary cortisol. Psychological variables and cortisol concentrations were generally negatively correlated within individuals indicating that over the short recovery period improving mood and cognition were associated with increasing levels of cortisol. A more consistent pattern of precedence of change was obtained for mood and cognition: negative cognitive style predicted changes in both mood measures and feeling unwell predicted changes in negative automatic thoughts.

Adult↗
PubMedDate not supplied

Lymphocyte glucocorticoid receptor binding in depression: normal values following recovery.

The number of glucocorticoid receptor sites in lymphocytes and plasma cortisol concentrations were measured in 20 patients who had recovered from major depressive disorder and 20 healthy control subjects. The number of glucocorticoid receptor sites in lymphocytes from the recovered depressed group was not significantly different from that of the control group. Although the mean plasma cortisol concentration in recovered depressives was higher than in control subjects, the difference only just reached significance. This study shows that the reduction in glucocorticoid receptor numbers which occurs during acute depressive illness does not persist on recovery and is, therefore, state-dependent.

Adult↗
PubMedDate not supplied

Sulpiride treatment of acute mania with a comparison of the effects on plasma hormone concentrations of lithium and sulpiride treatment.

Sulpiride, in this open study of acute manic patients, had a clear antimanic action with all eight patients responding to sulpiride treatment without the need for other antipsychotic drugs. Plasma prolactin concentrations were increased and oestrogen-stimulated neurophysin concentrations decreased by sulpiride but were unchanged by lithium treatment, whereas TSH concentrations showed a rapid increase following the introduction of lithium therapy.

Adult↗
PubMedDate not supplied

A tale of two islets.

Explore the source record for details and available documents.

Adenoma, Islet Cell↗
PubMedDate not supplied

Congo red birefringent structures in the hypothalamus in senile dementia of the Alzheimer type.

Serial cryostat sections of hypothalamus from four cases of Alzheimer-type dementia and four controls were stained with Congo red and examined for birefringence. Green birefringence and dichroism was associated with (a) neurofibrillary tangles, which were most numerous at the level of the tuberomammillary nucleus where they were found in large acetylcholinesterase-positive neurons; (b) neuropil processes within tangle fields; (c) a few plaque cores in the mammillary body; (d) spicules at the ependyma of the third ventricle, and (e) blood vessels. Birefringence (e) had different properties from (a) to (d) and was considered to be due to collagen. The ependymal spicules did not react with an antibody which recognized the tangles and neuropil processes. Each Alzheimer case had many more tangles than the control cases. Birefringence in (b)-(d) tended to be greater in the Alzheimer than in the control cases. This study confirms previous reports of large numbers of tangles in circumscribed areas of caudal hypothalamus in Alzheimer-type dementia and demonstrates that Congo red staining reveals abnormalities in hypothalamic structures (neuropil processes and ependyma) not demonstrated by other staining techniques.

Aged↗
PubMedDate not supplied

Effect of controlled exercise training in coronary artery disease patients with and without left ventricular dysfunction assessed by cardiopulmonary indices.

Cardiopulmonary indices were used to evaluate the effect of controlled exercise training prescribed on the basis of the heart rate at the ventilatory anaerobic threshold in coronary artery disease patients with and without impaired left ventricular function. Fifty-two patients aged 38-75 years were divided into four groups. The first three groups included patients with a left ventricular ejection fraction of > 45% at rest, as follows: group 1, 10 patients with single-vessel disease; group 2, 12 patients with two-vessel disease; group 3, 10 patients with three-vessel disease. Group 4 comprised 20 patients with left ventricular dysfunction (ejection fraction < 35%). The left ventricular ejection fraction was assessed by multigated acquisition radionuclear study. All patients underwent a cardiopulmonary exercise test before and after the program which lasted 6-9 months. The variables measured were oxygen consumption (VO2), CO2 output, minute ventilation, O2 pulse, and ventilatory anaerobic threshold. Significant improvements in maximal VO2, maximal O2 pulse, and ventilatory anaerobic threshold level were observed in groups 1, 2, and 4 (p < 0.1-0.0001), but not in group 3. These findings indicate that the overall cardiac function, as evaluated by cardiopulmonary indices, improves in patients with one- or two-vessel disease with good left ventricular function and in patients with impaired left ventricular function following an exercise training program. Severe coronary disease seems to limit improvement, even in the presence of a good left ventricular function. The results validate the heart rate at the ventilatory anaerobic threshold as the optimal training heart rate in coronary artery disease patients and the cardiopulmonary exercise test as a sensitive tool for evaluating exercise training results.

Adult↗