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Biomedical subjects

G Finardi

Publications and source records attributed to G Finardi.

At least 127 records · Page 7Linked to original sources

Noninvasive assessment of left ventricular function in myotonic muscular dystrophy.

In order to assess left ventricular function, measurements of left ventricular internal dimension and its rate of change have been made by echocardiography in 7 patients with myotonic dystrophy and the three children of one of them, who were clinically normal but had abnormal muscle biopsies. Electrocardiograms and systolic time intervals were also recorded in all. Only one patient had signs of overt heart disease and an abnormal electrocardiogram (type B WPW). Systolic time intervals were normal in all 7 patients. Five subjects had echocardiographic abnormalities, which were of minor degree except in the patient with overt heart disease who had considerable impairment of both systolic and diastolic left ventricular function. Another patient had abnormalities of both systolic and diastolic function; systolic abnormalities occurred alone in one patient and diastolic abnormalities alone in one relative. It is concluded that patients with myotonic dystrophy and no clinical signs of heart disease may have minor abnormalities of left ventricular function as shown by echocardiography. Echocardiography is more sensitive than systolic time intervals in detecting these abnormalities; both systolic and diastolic function abnormalities, alone or together, can occur. There seems to be no relation between involvement of skeletal and cardiac muscle.

Adolescent↗

[Contribution of the mechanocardiography to the study of obstructive chronic bronchopneumopathy].

Kinetocardiography, ECG and radiography, were compared as ways of obtaining early diagnosis of chronic cor pulmonale in two series of patients (81 in all) with chronic obstructive bronchopneumopathy. Kinetocardiography proved markedly superior in this respect. It revealed right ventricular pressure overload in a higher percentage of cases and at an earlier stage, i.e. when PAP values were little above normal resting values, of even when their increase appeared only during physical effort.

Adult↗

[The kinetocardiogram in complete left bundle branch block. Correlations between the kinetocardiogram and systolic time intervals (author's transl)].

The authors studied the possible correlations between the behaviour of the systolic time intervals, as measured by the electrophonosphygmographic patterns, and the behaviour of the kinetocardiogram recorded on left precordium, in 23 cases of complete LBBB. The results tend to confirm the possibility of distinguishing the distal from the proximal level of the conduction defect in a non invasive way, as already indicated in literature. Evidence for the former is the observation of a lengthening of the isovolumetric contraction time, of an increase of the PEP/LVET and ICT/LVET ratios, of a pansystolic bulge in KCG with a pathological amplitude of the atrial waves, all showing a left ventricular dysfunction. Evidence for a proximal level of conduction defect is: the normal length of the ICT, the normal PEP/LVET and ICT/LVET ratios, the absence of pathological atrial waves in KCG. The presence of paradoxical outward movement (POM) in KCG also in the latter case, even though only rarely observable as a pansystolic bulge, could be related to the existence of a form of ventricular dyssynergy, due to the deranged conduction of the impulse (ventricular dyskinesis from inter- or intra-ventricular asynchrony).

Adolescent↗