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Biomedical subjects

G Fillet

Publications and source records attributed to G Fillet.

144 records · Page 8Linked to original sources
PubMed1980

P1 incompatibility in pigeon breeders.

Pigeon breeders of the P2 blood phenotype may develop anti-P1 haemagglutinins as a consequence of natural immunization to pigeon dust. The half-life of labelled P1 erythrocytes was determined in two P2 pigeon breeders otherwise compatible except for the presence of anti-P1 antibodies and in four compatible controls without anti-P1. The half-life of tagged cells was within the normal range in one breeder but significantly reduced in the other, indicating that P1 incompatibility may occur in vivo. Since anti-P1 antibodies are found in about 20% of P2 pigeon breeders, it is suggested that this group may be prone to developing an incompatibility to transfused P1 red cells.

Animals↗
PubMed1978

[Myeloma].

Explore the source record for details and available documents.

Cytodiagnosis↗
PubMed1977

Effects of transfusion on serum iron, serum lactate dehydrogenase and platelets in megaloblastic anemia.

In 11 patients with megaloblastic anemia, transfusion of packed erythrocytes or washed erythrocytes invariably resulted in a decline in plasma iron concentration to a range of 20-90 microgram/dl (3.6-16 mumol/l) after 36 to 48 hours. The same phenomenon was observed in two of six cases of ineffective erythropoiesis without megaloblastosis and in none of five cases of aplastic anemia. The observed changes did not result from a specific hematinic response or from iron uptake by a non-erythroid compartment. In megaloblastic anemia, alteration in marrow function in response to transfusion was reflected by plasma iron kinetics and serum lactate dehydrogenase values, which indicated marked reductions in both marrow hyperplasia and ineffective erythropoiesis. Transfusion in megalobastic anemia was also responsible for a 50% reduction in platelet count after 2 to 6 days. The significance of these changes is discussed.

Adult↗
PubMed1974

Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport.

The processing of erythrocyte iron by the reticuloendothelial cell has been characterized by kinetic measurements of blood radioactivity made after the intravenous injection of heat-damaged erythrocytes labeled with (59)Fe and of transferrin-bound (55)Fe. The early reticuloendothelial release of iron, a matter of hours, was calculated from the plasma turnover rate of (55)Fe and the plasma reappearance of (59)Fe. Late release was calculated from the ratio of the cumulative incorporation of both tracers into the circulating red cell mass over a period of 2 wk. There was an initial processing period within the reticuloendothelial cell, after which radioiron either rapidly returned to circulation (t(1/2) 34 min) or was transferred to a slowly exchanging pool of storage iron within the reticuloendothelial cell (t(1/2) release to plasma of 7 days). These pathways were of equal magnitude in the normal dog. Reticuloendothelial release of iron was largely independent of the pre-existing plasma iron level or transferrin saturation. Diurnal fluctuations in the plasma iron level were shown to be the result of a variable partitioning of iron between the early and late release phases. Acute inflammation resulted in a prompt and marked increase in the fraction of iron stored (late phase), whereas depletion of iron stores resulted in a marked increase in early release.

Animals↗
PubMedDate not supplied

Monitoring of erythropoiesis by the serum transferrin receptor and erythropoietin.

Virtually all cells have transferrin receptors (a transmembrane glycoprotein) on their surface but in a normal adult, 80% of them are in the erythroid marrow. Some of them are lost into the circulation where they can be measured by immuno-assays. A direct and highly significant correlation exists between serum transferrin receptor level and erythron transferrin uptake in humans. The measurement of serum transferrin receptor has wide clinical applications for the quantitation of erythropoiesis. It can be used to study erythropoiesis in situations in which ferrokinetics is not acceptable such as pregnancy. It is particularly useful for serial studies, e.i., for monitoring the recovery of erythropoiesis after stem cell transplantation or after treatment with erythropoietin. Combined with the determination of serum erythropoietin, both evaluated in relation to the degree of anemia, they provide a physiological approach to the diagnosis of anemia. Thus, the simultaneous determination of hematocrit, reticulocytes, serum transferrin receptor and serum erythropoietin has high discriminatory value in distinguishing between a defect in erythroid proliferation, maturation or red cell survival. It is also particularly useful for detecting the presence of multiple mechanisms of anemia in the same patient.

Anemia, Iron-Deficiency↗