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Biomedical subjects

G Ferraris

Publications and source records attributed to G Ferraris.

At least 55 records · Page 3Linked to original sources
PubMed1987

Primary tumor receptorial status and axillary metastases: their prognostic significance.

Data on the prognostic value of receptorial status are controversial. On the basis of our results, receptorial status has no significance as an independent role; only the number of involved nodes and hormonal therapy have this prognostic role. Free of disease survival curves according Kaplan and Meier show that there are no statistically significant differences either in patients with low neoplastic recurrences (pN0) or in those patients with high risk (pN1) among women with tumor ER+ and ER-. Among 291 pN0 patients there was no relation between receptorial status (negative from 3 to 9 fmol/mg) and results of therapy on the follow-up. Among 248 pN1 patients therapy with tamoxifen had an influence on free interval both in the group with a low receptorial status and in particular in that with high receptorial level; no effects of therapy on the ER- patients. In the group of 248 pN1 patients with high receptorial status, the therapy was more successful in the group with a medium lymph nodal risk (from 1 to 3 positive nodes) and also in the group with G1 or G2. With regard to the study of the relation between lymph nodal metastases and receptorial status, we can state that lymph nodal levels data gives the main prognostic factor of risk. Therefore lymphadenectomy involving the three lymph nodal levels appears to be the crucial point in diagnostic and therapeutic surgical strategy of breast carcinoma.

Axilla↗
PubMed1987

Surgical strategy management following lymph nodal positivity at the three levels (a retrospective and perspective study).

The purpose of this study is to evaluate the type of distribution, regular or irregular, of metastases in lymph nodes of I, II and III level. We inted also to establish if the levels of lymph nodal areas represent an evaluation index of prognostic risk more effective than other ones. The results evidenced that in 19.2% of all the classes N+ metastases were not increasing regularly from the level I to the level III. The influence of seven factors on disease free survival has been evaluated: pT, pN, number of metastatic nodes, ER+ or ER-, PgR+ or PgR-, grading, metastatic level at axillary lymph nodes. The present report points out that only the extent of tumor and lymph nodal level have a statistically significant influence on disease free survival. Comparison among disease free survival curves stage N0 with N+ at I level and with N+ at II level revealed that there is no significant difference of survival among these classes, while the comparison between the first 3 classes and N+ at III level is statistically significant.

Adult↗
PubMed1983

EEG sleep patterns and endogenous opioids in infants of narcotic-addicted mothers.

The early symptoms of brain dysfunction in infants born to heroin-addicted mothers were studied during the first month of life by a multimethod approach. Neurological examination and polygraphic EEG studies of sleep patterns were performed; concomitantly plasma levels of beta-endorphin and met-enkephalin were measured. Whenever possible, these parameters were correlated with each other and with the severity of the withdrawal syndrome. While the neurological examination of addicted newborns was almost negative, altered sleep cycles with a decrease in active sleep and an increase in quiet sleep were noted together with a marked increase in the plasma concentration of the endogenous opioid peptides. Furthermore, instead of reverting to the adult values (as for normal babies), the peptides remained at high levels up to the 40th day of life.

Brain↗
PubMed1982

[Hypnosis in obstetrics and gynecology].

Since the basic problem in the use of hypnosis in physiopathological obstetric and gynaecological conditions is the choice of the right method for the right indications, the symptoms and clinical conditions which may benefit from this treatment are discussed. The following gynaecological indications are suggested: dysmenorrhoea and algomenorrhoea; hypogastric plexalgia; frigidity; dyspareunia and vaginismus; psychogenetic amenorrhoea; postoperative psychoses and depressions; gynaecological somatisations of psychotic states. In the obstetric field the main indication are: hiperemesis gravidarum; antenatal training and assistance in labour.

Affective Disorders, Psychotic↗
PubMed1981

Clinical assessment of gestational age in the newborn infant. Comparison of two methods.

A clinical assessment of gestational age was performed in a group of 92 newborn infants. The Dubowitz method (1970) based on 10 neurological and 11 "external" criteria and the Finnström method (1977) based on 7 "external" criteria have been applied. A comparison between these two methods showed a correct estimation of gestational age within +/- 2 weeks in 86.95% of cases with the Finnström method and in 80.72% of cases with the Dubowitz method. A correct estimation within +/- 3 weeks was found in more than 90% of the infants with both methods. No significant difference between the two methods was found. In about 10% of cases of Dubowitz method could not be applied because of the serious conditions of the infants. Assessment of gestational age with the Finnström method proves to be less stressful for the infant, less time consuming and feasible on a larger number of infants than the assessment with the Dubowitz method. For these reasons the Finnström method seems to be more advisable for clinical routine work.

Female↗