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Biomedical subjects

G Ferenc

Publications and source records attributed to G Ferenc.

5 recordsLinked to original sources
PubMed2005

A convenient method for the synthesis of oligonucleotide-cationic peptide conjugates.

A method was developed for the synthesis of oligonucleotide-cationic peptide conjugates in solution phase by disulfide bond formation. Precipitation was avoided by the easily removable triethylammonium trifluoroacetate (TEATFAc) salt which served at the same time as a buffer of the reaction mixture. The fast and high yielding disulfide bond formation was due to the Npys thio protecting and activating group of Cys. A solution of the free 5-thiol modified oligonucleotide obtained from Poly-Pak purification was used for conjugation.

Base Sequence↗
PubMed1976

Cell surface changes observed in MC-29 virus-infected chicken-embryo fibroblast (CEC) cultures.

By transmission and scanning electron microscopic studies of MC-29 virus-infected CEC cultures, C-type virus particles were detected in the medium of infected cultures, in infected cells and in intracellular vacuoles. Virus budding was also observed. In the scanning electron microscope (SEM) so-called blebs appeared on the surfaces of the infected cells, in a number proportional to the concentration of the virus preparation. On the basis of the size of the blebs, it could be considered that virus formation was taking place in their center. In control cells, neither viruses nor blebs were observed. This method will presumably be suitable for the titration of virus preparations.

Animals↗
PubMed1975

[Injuries of the cervical spine].

In connection with 44 patients, who suffered injuries of the cervical spine, the types of the fracture and dislocation of the cervical spine are discussed. The injuries of the cervical spine--with or without injury of the spinal marrow--signify hard tast in respect of therapy. The conservative (extension) treatment of surgical intervention are even nowadays much debated themes in the neurosurgery. The introduction of Crutchfield tongs was a definite advance in the latter years. With this treatment method the restitution of the form, continuity and stability of the cervical spine is possible. In the opinion of the authors, surgical intervention (laminectomy) is necessary only in the case of progressive symptoms of compression of the cervival marrow (liquorstop). The survival of the patients depends often on the quick and proper treatment. The prevention of complications and the quick elimination are of great importance. Safeguarding of the physical and psychical conditions of the patients is the essential requirement of their rehabilitation after injuries of the cervical spine.

Accidents, Occupational↗