Cryotherapy for palliation in rectal carcinoma.
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Biomedical subjects
Publications and source records attributed to G Feifel.
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Since its introduction through Hollander 30 years ago the interpretation of the value of the insulin test following vagotomy have been discussed. For the individual patient no correlation between the incidence of ulcer recurrence and the result of the insulin test has been found. In addition, the risk of hypoglycemia seems to be too high for diagnostic purposes. Therefore, to evaluate the outcome after vagotomy basal acid output, pentagastrin stimulated acid secretion and endoscopy are emphasized as reliable methods.
The monitoring power of CEA during cryotherapeutic management was investigated in a group of 39 patients with inoperable cancer of the rectum. By the results it is concluded that the determination of serial serum CEA levels during cryosurgery is not only a useful parameter of the results of local treatment but also a sensitive indicator of tumor metastases.
The essential problem of acute gastrointestinal bleeding is hemorrhagic shock. Using a high-power Nd-Yag laser, transmitted endoscopically by Dr. Nath's triconic quartz fiber, it was possible to occlude massive arterial bleeding ulcers immediately after endoscopic localization. Of 202 bleeding ulcers in the upper gastrointestinal tract, 193 = 96% could be stopped. The mortality rate was reduced in bleeding acute ulcers from 58% to 36% and in bleeding chronic ulcers from 21% to 5.1%.
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In the Surgical Clinic of the University of Munich, 23 surgical interventions were performed on 20 hemophiliac patients between 1967 and 1976. There were 13 emergency and 10 elective operations. The spectrum ranged from removal of atheroma to subtotal gastric resection. For adequate substitution of factors a comprehensive preoperative "hemostasis profile", selection of a suitable preparation and postoperative supervision with coagulation analysis are necessary. Despite a normalization of the hemostasis, atraumatic surgical technique is particularly important. Risks of substitution therapy are primarily hepatitis, allergic reactions and the appearance of inhibitors. Whereas, especially using low-fibrogenic substrates, the operative risk is not essentially increased, in our experience the patients seem to be endangered particularly by infection and septic complications.
In the treatment of peptic gastroduodenal ulcers the modified vagomotor electrotest according to Burge has yielded remarkably good results as an intraoperative test for the completeness of proximal selective vagotomy (PSV). The test is as useful for the surgeon in training as for the expert in vagotomy. Moreover the clinical value of the test is demonstrated. If, according to this test, vagotomy is complete, an extreme reduction of gastric acid and a very low rate of relapsing ulcers are seen in our patients. We cannot recommend performing the PSV without this test.
From 1967 to 1976, 158 patients were operated on for recurrent ulcer; of these, 75 patients had an ulcus pepticum jejuni after Billroth II. The most common causes of the p. op. ulcer arose from inadequate surgical techniques, i.e., incomplete vagotomy, retained gastric antrum, too large gastric remnant, or palliative primary intervention, such as simple closure. The results of retrospective analysis do not permit a comparison of the different procedures. Vagotomy (p.s.V.), however, is recommended because of lower mortality. Zollinger-Ellison syndrome must be ruled out before any reintervention for recurrent ulcer is undertaken.
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Selective proximal vagotomy (SPV) decreases the LES pressure (resting pressure and pentagastrin-stimulated pressure), significantly 6 months postoperatively without achieving LES insufficiency by clinical means. Immediately after stimulation LES pressure is identical, compared to preoperative measurements. The postoperative significantly increased concentration of basal gastrin seems not to be a major determinant of LES tone in humans.
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Selective proximal vagotomy (SPV) decreases the LES pressure (resting pressure and pentagastrin-stimulated pressure), significantly 6 months postoperatively without achieving LES insufficiency by clinical means. Immediately after stimulation LES pressure is identical, compared to preoperative measurements. Concentration of serum gastrin is not a major determinant of LES tone in humans.
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