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Biomedical subjects

G Feeney

Publications and source records attributed to G Feeney.

10 recordsLinked to original sources
PubMed2001

The p107 tumor suppressor induces stable E2F DNA binding to repress target promoters.

E2F transcription factors are key players in the regulation of proliferation, apoptosis, and differentiation in mammalian cells. E2Fs are negatively regulated by members of the retinoblastoma protein family, Rb, p107 and p130. During adenovirus infection, viral proteins are expressed that displace Rb family members from E2Fs and recruit E2F complexes to viral and cellular promoter regions. This recruitment of E2F involves the induction of stable E2F binding to inverted E2F binding sites in the Ad E2a and cellular E2F-1 promoters and induces both viral and cellular gene expression. The cellular p107 tumor suppressor also displays such regulation of E2F DNA binding activity. p107 induces stable E2F-4/DP binding to inverted E2F binding sites in the Ad E2a and cellular E2F-1 promoters. The induction of E2F DNA binding by p107 minimally requires the sequences in p107 that mediate E2F interaction. The related tumor suppressor, p130, also effects this function. p107 levels increase substantially as cells progress through S phase. p107 induction of E2F DNA binding was observed primarily in S phase cells coincident with the increase in p107 protein levels. The results of promoter activity assays directly correlate the induction of E2F DNA binding by p107 with effective transcriptional repression. These results support a model in which p107 and p130 induce the stable binding of E2F complexes to promoters that drive expression of critical regulatory proteins such as E2F-1. Since p107 and p130 bind histone deacetylase complexes (HDACs) which repress promoter activity, p107-E2F and p130-E2F would stably recruit repressor complexes to effect efficient promoter repression.

Binding Sites↗
PubMed2001

One and a half centuries of demographic transition in Nepal.

This paper examines the past and prospective demographic transition in Nepal. Sparse data from the pre-1961 censuses suggest that mortality decline began during 1930s and allow rough estimates of fertility and mortality levels prior to 1961. Fertility decline began sometime between 1961 and early 1980s, with the total fertility rate declining from about 6 to 5 children per woman by early 1990s. The four scenarios of future fertility decline and population growth presented in the paper help draw several conclusions. A continuation of the recent slow pace of fertility decline would result in a total population of slightly over 100 million by the end of the next century (Scenario I). More rapid decline, similar to the median experience of Asian countries, would reduce this growth to below 60 million (Scenario III). Still more rapid decline, close to the limit of what has been observed in countries that have experienced the most rapid declines, could reduce the growth to 40 million (Scenario IV). It is possible, if not at present particularly plausible, that very rapid decline might be achieved by a combination of smaller family sizes and rising age of childbearing. An approach to reaching zero population growth rapidly--and anything less than a doubling of current population--may be ruled out with a high degree of certainty (Scenario II and IV). A doubling of population to 40 million is the least possible growth that can be expected. At the current rate of fertility decline, population will increase to 100 million during this century. If a smaller population in this range is considered to be in the national interest, it is as important to work for more rapid fertility decline as it is to work for accommodation of a much larger population.

Age Distribution↗
PubMed1994

Fertility decline in East Asia.

With the fall of fertility in China to near or below replacement levels in the early 1990s, the whole of East Asia may now be said to have completed a demographic transition. Its experience lies between that of the West and the many developing countries in which demographic transition is now under way. The main features and possible underlying causes of the fertility declines in Japan, Taiwan, South Korea, and China during this century are discussed. Fertility decline in East Asia is interesting both in its own right, as a chapter in the history of human reproduction, and for the light it may shed on fertility decline in the rest of the world.

China↗
PubMed1991

Fertility decline in Taiwan: a study using parity progression ratios.

Taiwan's decline in fertility is studied by using period parity progression ratios. Levels of marriage and motherhood are found to have been high and essentially constant though the late 1980s, suggesting that the decline has been due almost entirely to declines in second and higher order-births. Families with three or more children play an important role in maintaining the current level of fertility. The level of fertility would be even lower without these families. They contributed more than one-half child per woman to the total fertility rate during most of the 1980s. Total fertility rates computed from the period parity progression ratios indicate a substantially higher level of fertility than the conventional total fertility rate; they remained above or at replacement level through 1988. A formal demographic analysis suggests that the conventional total fertility rate has been depressed by shifts in age at childbearing.

Adult↗
PubMed1990

Untilting age distributions: a transformation for graphical analysis.

"This article presents a new approach to the plotting of age distribution data. 'Untilting' is a way of transforming data that vary systematically from very high to very low values so as to show local variation more clearly. The article derives an untilting transformation from the formal structure of age distributions. The transformation turns out to be closely related to two familiar demographic techniques, reverse-survival estimation of births and birth rates, and comparison of observed with stable age distributions. The ideas are illustrated by application to age distributions from the 1979 and 1989 censuses of Vietnam."

Age Distribution↗
PubMedDate not supplied

Child survivorship estimation: methods and data analysis.

"The past 20 years have seen extensive elaboration, refinement, and application of the original Brass method for estimating infant and child mortality from child survivorship data. This experience has confirmed the overall usefulness of the methods beyond question, but it has also shown that...estimates must be analyzed in relation to other relevant information before useful conclusions about the level and trend of mortality can be drawn.... This article aims to illustrate the importance of data analysis through a series of examples, including data for the Eastern Malaysian state of Sarawak, Mexico, Thailand, and Indonesia. Specific maneuvers include plotting completed parity distributions and 'time-plotting' mean numbers of children ever born from successive censuses. A substantive conclusion of general interest is that data for older women are not so widely defective as generally supposed."

Americas↗