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Biomedical subjects

G Fedder

Publications and source records attributed to G Fedder.

17 recordsLinked to original sources

[A man with Campylobacter endocarditis, treatable as Campylobacter fetus following identification].

A 48-year-old Dutch patient presented with general malaise, recurrent fever and weight loss. Routine cultures identified a Campylobacter in two blood cultures. When initial treatment with clarithromycin failed, the patient developed endocarditis. DNA sequencing identified Campylobacter fetus subspecies fetus (C. fetus). The patient recovered after treatment of the infection with imipenem and gentamycin, based on the minimal inhibiting concentration. C. fetus is a rare cause of infection in humans and is mostly transmitted by handling infected animal material. The patient contracted the infection as a result of a puncture accident with a butcher's knife about a year previously whilst working in a slaughterhouse.

Abattoirs↗

The association of Sweet's syndrome with sarcoidosis.

We report a 43-year-old woman with biopsy proven Sweet's syndrome with massive mediastinal lymphadenopathy. No other clinical signs compatible with sarcoidosis were present. Mediastinoscopy was performed to establish a diagnosis. Histological evaluation revealed non-caseating granulomas compatible with sarcoidosis. We review the association of Sweet's syndrome and (haematological) malignancies, and eight other cases of Sweet's syndrome and sarcoidosis. All but one presented with erythema nodosum, making the diagnosis of acute sarcoidosis (Löfgren's syndrome) more likely than malignancy.

Adult↗

[Skin lesions as a rare initial symptom of Kahler's disease].

Multiple skin lesions developed in a 70 year-old-man. Pathological examination revealed plasmacytomas. Because of the presence of a IgD paraprotein and 15% abnormal plasma cells in the bone marrow Kahler's disease of the IgD type was diagnosed. In accordance with literature the course of the disease was rapidly progressive. After an initial favourable response to chemotherapy and radiotherapy, the patient died one year after diagnosis. Extraosseous tissue involvement and hepatosplenomegaly are well-known phenomenon of IgD-Kahler's disease. Skin plasmacytomas as the first symptom of the disease are very rare.

Aged↗