Dialyzable serum factors after cellular immunity in pregnancy.
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Biomedical subjects
Publications and source records attributed to G Fabian.
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The possibilities of a combination of modified injection techniques are described. This allows the lymphokinetic effect of a drug to produce a definite improvement in the morphological demonstration of the lymphatics.
The morphological changes in the uterine lymphatics in aging nulliparous and multiparous mice, as shown by the application of dyestuffs (patient blue violet and Japan ink) are described, and their appearance corresponds to that described in earlier papiers by Fabian (1976, 1977, 1978). It is apparent on the basis of these findings that with the cessation of the sexual cycle, the previous regularly repeated morphological changes in the mouses uterus move into another stage, and associated with this the lymphatics inevitably take part in the aging process. According to Lindner (1975) this is essentially a dynamic process, rather than one which is purely passive, dengerative or involutional.
By means of orthograde and retrograde application of dyestuffs (using patent blue violet and Japan ink) one can successfully demonstrate the uterine lymphatics in juvenile mice, up to the onset of sexual maturity. However, the three subgroups used here do not show the typical features of the cyclical events of nulliparous and parous mice. However, the morphological changes already present, allow one even now to recognize, that with the increasing sequence of individual sexual cycles, cyclical changes in the uterine lymphatics of the mouse were identified.
When adapted to the natural possibility of reabsorption of the uterus, using the dye Patent Blue Violet and Japanese ink, the orthograde demonstration of the cyclical behaviour of the lymphatics during the oestrus cycle was successful even with parous mice. As investigations have already shown in nulliparous mice (5), the characteristic variations in all five stages of the sexual cycle are also found here: As a result of the pregnancies the lymphatics of the endometrium are more strongly developed, in contrast to the nulliparous mouse. However, in the stage of pre-oestrus and oestrus the marked or very marked widening, of varying calibre does not show in such a striking way. In the subsequent two stages of the secual cycle prominent elevations are found in the lumen of the uterus, and these have lymphatic capillaries running in them. The further stage, a more or less reticulate arrangement of the lymphatic capillaries, with fine branching ramifications, is equally typical. As a result of the pregnancies, the larger lymphatic vessels are often curled up like a cork-screw, and also show their typical beaded appearance.
In a female mouse sacrificed at the age of 3--3/12 years, corpus heamorrhagicum and arteric corpora lutea were found in the ovaries, apart from smaller follicles. No evidence could be found in the literature for their presence at this age. Based on these findings, aspects of basic gerontological research are discussed.
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Orthograde delineation and characterization of the lymph vascular system in the uterus of the mouse during the sexual cycle was achieved by absorption of Patent Blue Violet and Japan ink. The lymph vessels in the endometrium are dilated by about 8-10 times and of varying calibre during oestrus. A reticular arrangement is characteristic of the subsequent stages, while the picture during pre-oestrus resembles that of oestrus. The dye is carried away very rapidly through the larger lymph vessels in the mesometrium which have their typical string of pearls appearance.
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After a review of the methods for treating tracheal stenosis, own results of 20 cases are reported, concerning 6 with subglottic stenosis, 7 localized in the cervical and 4 in the thoracic region, in 3 other cases the cervical and thoracic region was involved. The stenosis was the sequela of tracheotomy in 12 cases, of extended inflammations in 3 cases, of benign subglottic tumors in 3 cases and 2 following intubation. 3 dilatations, 7 tracheopexies and 7 tracheoplastics were performed. In 1 patient the stenosed portion was resected followed by end-to-end-anastomosis. Complete unrestricted respiration was achieved in 11 patients, adequate breathing at rest in 4 patients, and 3 patients had to continue wearing a tube. 3 patients died, 2 of them from other causes and 1 from inadequate postoperative care. The treatment procedures must be individualized to each patient, according to the different causes, sites, types of the tracheal stenosis, to improve diagnostics, and the preoperative and postoperative care. Great patience from the side of the patient as well as the physician is necessary to relieve the patient suffering from his severe dyspnea.
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