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Biomedical subjects

G F Moore

Publications and source records attributed to G F Moore.

At least 37 records · Page 2Linked to original sources
PubMed1992

Cerebrospinal fluid rhinorrhea: a review of the literature.

CSF rhinorrhea may be spontaneous or traumatic, the majority of cases being traumatic and presenting within the first three months. Spontaneous leaks imply an underlying abnormality which must be identified prior to treatment. Diagnosis and identification of the site of the leak is often inaccurate, even with meticulous care given to placing and removing the nasal pledgets. Once the leak is identified, medical or surgical treatment may be attempted. Recurrent leaks are common and serial operative procedures have been reported to stop even small leaks.

Cerebrospinal Fluid Rhinorrhea↗
PubMed1992

Use of electroneuronography in monitoring facial nerve paralysis.

FNP is a disease entity seen in a variety of clinical settings. We recommend early ENoG evaluation of every total facial nerve paralysis to assess the percentage of degeneration. ENoG is an objective, permanent record with prognostic significance especially in 16% of those patients who are predicted to have a poor outcome without further intervention. In consultation with the patient a treatment plan can thus be proposed to optimize the opportunity for recovery.

Adolescent↗
PubMed1991

Serum selenium concentrations in rheumatoid arthritis.

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

Adult↗
PubMed1991

Lightning and its effects on the auditory system.

Patients struck by lightning can present with a wide variety of unusual otologic problems including burns to the external auditory canal, tympanic membrane rupture, middle ear injury, and sensorineural hearing loss. Four patients who incurred various otologic problems, including one patient with previously unreported bilateral oval window fistulas following lightning injury, are presented. Audiologic, otologic, and surgical findings are reviewed as well as patient follow-up and outcome.

Adult↗
PubMed1990

Facial nerve paralysis.

Bell's palsy, an idiopathic facial nerve palsy, is the most common cause for acute facial nerve paralysis. Bell's palsy is not synonymous with facial nerve paralysis but is a diagnosis of exclusion for acute onset of idiopathic facial nerve paralysis. The differential diagnosis for facial nerve paralysis should be considered to correctly evaluate and give appropriate therapy in a timely fashion for the treatable causes of facial nerve paralysis. The status of facial nerve paralysis should be monitored by repeat electrical examinations, preferably ENoG. Most importantly, no one treatment is appropriate for all patients with facial nerve paralysis.

Diagnosis, Differential↗
PubMed1990

Bell's palsy: a facial nerve paralysis diagnosis of exclusion.

Bell's Palsy is not synonymous with facial nerve paralysis. While it is a common cause of facial nerve paralysis, it is a diagnosis of exclusion and other causes of facial nerve paralysis should be ruled out by appropriate evaluation and follow-up. A case report is presented of a patient with a facial nerve paralysis, which was initially diagnosed as Bell's Palsy, but which was found to be a poorly differentiated parotid malignancy causing facial nerve paralysis. A review and discussion of Bells Palsy, evaluation and treatment is presented.

Age Factors↗
PubMed1989

Jugular foramen peripheral nerve sheath tumors.

Though jugular foramen nerve sheath tumors are uncommon, they involve a critical area of the skull base. Therefore, a precise classification system is needed to accurately define the extent of these tumors and reflect their surgical management. A series of seven cases is reviewed incorporating such a classification system to illustrate the management of these lesions using the infratemporal fossa type A approach.

Adolescent↗
PubMed1987

Thromboangiitis obliterans (Buerger's disease) and smokeless tobacco.

Thromboangiitis obliterans, a distinct clinical and pathologic entity characterized by segmental inflammatory and proliferative lesions of the tunica media of small arteries and veins, has been reported frequently in men who have a history of heavy cigarette smoking. We report a case of thromboangiitis obliterans in a 38-year-old man that was clearly associated with the use of smokeless (chewing) tobacco. In addition to a physical history and examination and laboratory evaluation, a biopsy of the skin and deep subcutaneous tissue of the patient's left thigh was performed, and this revealed occlusion of 2 large dermal blood vessels by a highly organized thrombus. A regimen of nifedipine and antiplatelet therapy, plus complete abstinence from tobacco, resulted in resolution of the patient's symptoms and pain. Our findings may be of particular importance in view of the increasing popularity of smokeless tobacco and the complications which may result from its use.

Adult↗
PubMed1987

Prevalence of thyroid disease and abnormal thyroid function test results in patients with systemic lupus erythematosus.

Although thyroid disease has been associated with other autoimmune conditions, it is not well recognized in systemic lupus erythematosus (SLE) patients. We found that in 332 SLE patients hospitalized during a 5-year period, the overall prevalence of diagnosed thyroid disease (7.5%) was similar to that in other female populations, but the prevalence of diagnosed hypothyroidism (6.6%) was unexpectedly high. There was also a high frequency of abnormal thyroid function test results in 175 SLE patients without diagnosed thyroid disease who underwent laboratory screening. More than 45% of these patients had elevated levels of thyroid-stimulating hormone, 34% had low T3 determinations, and 18% had high antimicrosomal antibody titers. When patients were categorized into "functional groups," some showed evidence of the "euthyroid sick syndrome" (15%), but many more had laboratory test results suggestive of true (5%) or incipient (39%) primary hypothyroidism. We conclude that abnormal thyroid function test results are common in patients with SLE and that hypothyroidism, especially, should be considered when evaluating symptoms and signs in SLE patients.

Adolescent↗
PubMed1987

Outcome of locally advanced stage III and IV head and neck cancer treated by surgery and postoperative external beam radiotherapy.

An uncontrolled retrospective analysis of 76 patients with locally advanced Stage III and Stage IV squamous cell carcinoma of the oral cavity, oropharynx, pyriform sinus, supraglottic larynx, glottic larynx, and hypopharynx, who were treated in a uniform manner by surgical resection and 6,600 rad postoperative external beam radiotherapy, revealed relatively high 2-year and 4-year adjusted survival rates of 76% and 68%, respectively. Complication rates were acceptable (8%). The advantages of this treatment approach for locally advanced head and neck cancers compared to treatment by surgery alone are discussed.

Carcinoma, Squamous Cell↗
PubMed1987

Transient salivary gland hypertrophy in bulimics.

Transient salivary gland hypertrophy is a reported clinical finding in patients with bulimia. A retrospective chart review of 49 patients enrolled in the University of Nebraska Medical Center Eating Disorders Program with a diagnosis of bulimia showed 29% (14/49) had at some time either parotid and/or submandibular gland hypertrophy noted on physical exam. Resolution of the salivary gland enlargement occurred in all of our patients after treatment of their bulimia. Bulimia must, therefore, be considered in the differential diagnosis of salivary gland hypertrophy, and treatment should be directed at the underlying behavioral disorder.

Adult↗
PubMed1986

Endocrine responses and examination anxiety.

Endocrine and psychological function (measuring both affect and attitudes to study) were studied in 38 male medical students 4 weeks and 1-2 h before a major examination. Anxiety (or tension) and emotionality increased just before the examination, as did the 'denial' subscale of a 'coping' questionnaire. Serum cortisol and prolactin increased; serum testosterone and LH were unchanged. Both urinary noradrenaline and adrenaline were elevated. Increased cortisol correlated with increased prolactin across subjects; so, too, did levels of urinary noradrenaline and adrenaline, but the two sets of endocrine responses were not correlated with each other. Several of the trait scales predicted the endocrine response to the examination. The 'lie' scale of the Eysenck Personality Questionnaire correlated negatively with changes in both cortisol and prolactin, as did 'debilitating' anxiety, as defined by the Alpert-Haber scale. However, although there were no significant correlations between changes in hormone levels and those in any of the state scales, there was some relation between absolute hormone levels on the day of the examination. Measures of academic strategies or psychological responses to examinations do not predict the nature of the considerable hormonal response which occurs in this homogeneous set of high-achieving students.

Anxiety↗
PubMed1986

Abducens nerve paralysis: a potential presentation of sphenoid sinus cancer.

The sphenoid sinus is the paranasal sinus most commonly implicated when cranial neuropathies are present. Two patients presenting with sixth nerve paralysis secondary to sphenoid sinus involvement are presented. One patient had a primary sphenoid sinus tumor, and the other a metastasis from a bronchogenic carcinoma. Of the two patients, one carried the diagnosis of idiopathic sixth nerve paresis and had had a normal sinus x-ray film and CAT scan done previously. Even in the absence of positive radiographic findings, the high clinical suspicion of sinus malignancy must be maintained in patients manifesting abducens nerve paralysis. In these patients, the petrous apex and cavernous sinus "silent area" must be diligently evaluated. For the patient to have any chance for palliation or potential cure, the tumor must be diagnosed as soon as possible.

Abducens Nerve↗