Biomedical subjects

G F Gates

Publications and source records attributed to G F Gates.

At least 55 records · Page 3Linked to original sources

PubMed1977

Hepatic cavernous hemangiomas and hemangioendotheliomas in infancy.

Six infants with either cavernous hemangiomas or hemangioendotheliomas of the liver are described. Typical clinical features include cardiac failure, hepatomegaly, and cutaneous hamangiomas. Prompt recognition will direct management to prevent lethal complications of cardiac failure, hyperconsumptive coagulopathy, and hepatic rupture. Dynamic and static hepatic scintigraphy will demonstrate the vascularity and size of the liver mass and provide distinction from other tumors, although in certain circumstances angiography is required.

Angiography↗

PubMed1977

Suitability of radiopharmaceuticals for determining right-to-left shunting: concise communication.

Right-to-left shunting in noncyanotic patients was quantitated following the injection of either 99mTc-microspheres, 99mTc-macroaggregated albumin, or 113mIn-Fe(OH)3 particles. Shunting was determined by wholebody scanning followed by estimation of the nuclide fraction located in the systemic circulation. Both 99mTc-labeled radiopharmaceuticals yielded results consistent with normal pulmonary shunting in a noncyanotic patient, whereas 113mIn-Fe(OH)3 was less satisfactory. If the onset of scanning was delayed, however, the calculated shunt can be falsely elevated as the pulmonary particles fragment and pass onward or as the label is released. Consequently, proper choice of radiopharmaceutical and prompt scanning are crucial for accurate quantitation of right-to-left shunting.

Adolescent↗

PubMed1976

Radionuclide imaging of airway obstruction following assisted ventilation.

Radioaerosol lung scintigraphy was performed in five infants in whom obstructive airway complications developed following assisted ventilation. These studies suggest that a primary functional defect was obstruction to airflow at the level of the major airways, which occurred during expiration. Perfusion lung scintigraphy showed areas of diminished or redistributed pulmonary blood flow, which, like the results of the radioaerosol scintigraphic studies, are findings often associated with adult chronic obstructive pulmonary disease.

Airway Obstruction↗

PubMed1976

"Watershed" infarction in sickle cell disease.

A classical "watershed" infarction pattern on brain scintigraphy was demonstrated in a seven-year-old black girl with sickle cell disease. Computed tomography (CT) showed minimal abnormalities compared to the characteristic findings on the radionuclide image.

Anemia, Sickle Cell↗

PubMed1976

Maxillary-facial abnormalities assessed by bone imaging.

Eighty-eight patients with maxillary-facial abnormalities were studied with 99mTc-labeled phosphate compounds. Straight and tilted anterior views plus oblique orbital and lateral views were correlated with 201 thallium transmission images of a dried skull. Interpretation of any single view may be hampered by various superimposed structures. Careful patient positioning with multiple views allows for parallactic correlation which is crucial if radiotherapy, biopsy, or corroborative studies are planned.

Adult↗

PubMed1976

Ovarian carcinoma imaged by 99mTc-pyrophosphate: case report.

An ovarian carcinoma which avidly accumulated 99mTc-pyrophosphate was imaged during a bone scan. The primary tumor and its implants over the liver surface were both visualized. Although imaging of such an ovarian malignancy has not been previously reported, it offers a potential method for assessing neoplastic size and spread.

Adult↗

PubMed1975

The hyperperfused lung. Detection in congenital heart disease.

Thirty-nine children with various cardiac abnormalities were examined with perfusion lung scintigraphy with technetium Tc 99m macroaggregated albumin. Nuclide accumulation within each lung, which is proportional to the division of pulmonary arterial flow, was determined. Twenty-six patients had hyperperfusion of one lung, with a particularly high incidence occurring with the tetraoloy of Fallot, pulmonary artery stenosis or atresia, and following surgical systemic-pulmonic anastomoses. Consistent detection of imbalance in pulmonary flow by inspection of chest x-ray films was possible when one lung received at least 2 1/2 times the blood flow of the opposite side; with angiography, flow imbalance could be recognized when flow in one lung exceeded flow in the other by only 1 1/2 times. The radionuclide quantitative method was a more sensitive means of detecting early cases of mismatched pulmonary blood flow than roentgenography, which was nonquantitative and required the presence of relatively gross perfusion abnormalities before visual perception was possible.

Age Factors↗

PubMed1975

Detection of craniosynostosis by bone scanning.

Growth patterns of the cranial sutures were studied by bone scanning in 29 children, 13 of whom had craniosynostosis. Primary craniosynostosis was initiated by localized bony fusion across a suture, associated with an abnormal accumulation of bone-seeking radiopharmaceuticals. As the abnormal fusion process extended along the suture, there was a corresponding spread of radionuclide. With complete fusion, uptake diminished. In addition to calvarial scanning, three abnormal sutures were scanned following surgical excision, which allowed direct comparison in vivo and in vitro. Calvarial bone scanning is helpful in the early detection of primary craniosynostosis.

Adolescent↗

PubMed1975

Surgery of congenital heart disease assessed by radionuclide scintigraphy.

Intravenous injection of 99mTc-labeled macroaggregated albumin (MAA) followed by lung and whole-body scintigraphy results in data from which magnitude of right-to-left shunting and distribution of pulmonary arterial blood flow can be calculated. This information is useful in assessing the functional capacity of a surgical systemic-pulmonic anastomosis. Malfunctioning anastomoses do not significantly reduce right-to-left shunting and may cause unilateral pulmonary hyperperfusion. However, preferential nuclide accumulation may occur in either lung, regardless of shunt function. Consequently, the degree of right-to-left shunting must be determined to fully assess a surgical anastomosis. This technique also allows for assessment of the reduction of right-to-left shunting after intracardiac repairs of congenital cardiac abnormalities.

Child, Preschool↗

PubMed1974