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Biomedical subjects

G F Altomare

Publications and source records attributed to G F Altomare.

At least 55 records · Page 3Linked to original sources
PubMed1986

Isotretinoin versus minocycline in cystic acne: a study of lipid metabolism.

We have recently reported that patients with severe nodular cystic acne have much lower levels of HDL-cholesterol, apolipoprotein A and hepatic lipoprotein lipase than healthy controls or subjects with acne vulgaris. Since isotretinoin is very effective in the treatment of the nodular cystic acne but has been shown to increase blood lipid levels, we decided to compare its clinical effectiveness and its effects on lipid metabolism with those of minocycline in patients with nodular cystic acne. After 20 weeks, the number and mean diameter of the cysts were definitely decreased in both groups, but the improvement was more striking in the isotretinoin-treated group. At the end of the treatment, the HDL-C and hepatic lipoprotein lipase levels in this group were increased toward normal, but not in the minocycline-treated group. Our study showed a significant remission in the acne of patients treated with isotretinoin but not in that of the minocycline-treated patients. Furthermore isotretinoin can also correct the altered lipid metabolism in these patients.

Acne Vulgaris↗
PubMed1985

Lipoprotein metabolism and lipoprotein lipase in severe cystic acne.

In severe cystic acne we found low levels of high density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) in the presence of normal total lipids. In a larger number of patients, we always observed significantly lower levels of HDL-C and Apo-A than in either age-matched controls or subjects with acne vulgaris. Since lipoprotein lipase is one major determinant of HDL concentration, we assayed the lipase activity in liver and extra-hepatic tissues by the method of Krauss et al. There was highly significant less total and hepatic lipase activity than in age-matched controls. HDL distribution was examined by zonal ultracentrifugation and a decrease in the HDL2 subclass was discovered. Since HDL are inversely correlated to atherosclerosis, cystic acne is one risk factor for atherosclerosis. The linkage between low HDL levels and severe cystic acne should be further investigated.

Acne Vulgaris↗
PubMed1984

Unusual cases of Meleda keratoderma treated with aromatic retinoid etretinate.

We studied a brother and sister of South Italian origin with palmoplantar keratoderma which, because of the clinical aspects (transgrediens et progrediens), mode of inheritance (autosomal recessive) and evolution, we diagnosed as Meleda keratoderma with particular clinical features (presence of ainhum-like narrowings and concomitant lesions at other sites). Appropriate classical histologic and familial investigations, as well as HLA typing were done, and retinol-binding protein values were determined. The patients were treated with the aromatic retinoid etretinate, and the clinical and histological results after 9 months' treatment are reported.

Adult↗
PubMed1984

Fixed drug eruption to erythromycin.

A case of repeated eruption after administration of erythromycin is described. It is the first report of erythromycin as proven agent of such an allergic reaction.

Drug Eruptions↗
PubMed1984

The role of mycoplasmas in sexually transmitted vaginitis.

Mycoplasmas were isolated from 325 female subjects who came to a gynaecological out-patient clinic for many different reasons. Micro-organisms can also be isolated in a high percentage from apparently healthy subjects. Our data indicate that mycoplasma can be either simple commensals in the uro-genital apparatus or saprophytes. In vulvo-vaginitis mycoplasma can cause a type of pathology which is always associated with the presence of other pathogens.

Adolescent↗
PubMed1984

Hyper IgE syndrome: four case report.

Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin (TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.

Antibodies, Monoclonal↗
PubMed1983

[Bacteriological study at the vaginal level in sexually active women].

We have studied the microbiological environment of the vagina in 202 sexually active women when they came into an outpatient gynecological hospital. By some specific bacterioscopic and cultural examinations we have tried to understand the pathological role of some microrganism in sexually transmitted diseases. An elevated incidence of mycoplasm in asymptomatic subjects has shed light on the probable saprophytic behaviour of these microrganisms.

Adolescent↗
PubMed1983

[Contact urticaria. Experimental contribution].

Contact urticaria is characterized by erythematosus whealing lesions after apposition of particular substances on the skin. Sometimes these substances are able to determine systemic reactions as rhinoconjunctivitis, bronchial asthma, gastrointestinal dysfunction and anaphylactic shock: these symptoms justify the denomination of contact urticaria syndrome. It can be classified as Immunological, not Immunological and Unidentified. Our cases show a sharp prevalence of contact urticaria caused by foods and especially by fruits and vegetables.

Dermatitis, Contact↗
PubMed1983

Effect of etretinate on chemotaxis of neutrophils from patients with pustular and vulgar psoriasis.

The chemotactic activities of neutrophil granulocytes of patients with pustular and vulgar psoriasis were evaluated before and after treatment with etretinate. Control values before treatment were significantly different from those of vulgar psoriasis group but not from the pustular psoriasis group. The difference between the 2 groups with psoriasis was significant. Etretinate causes a significant reduction in neutrophil chemotaxis in pustular psoriasis patients and a less pronounced reduction in those with vulgar psoriasis.

Adolescent↗
PubMed1983

Effects of isotretinoin on the neutrophil chemotaxis in cystic acne.

The authors show that the use of Isotretinoin (Ro 4-3740) in cystic acne brings a reduction of chemotactic activity of the neutrophil granulocytes, like another retinoid, Etretinate, in pustular and vulgar psoriasis. This effect of retinoids, with a direct action on the polymorphonuclear leukocytes plays an important role in the recovery of the disease.

Acne Vulgaris↗