Biomedical subjects
Publications and source records attributed to G Eriksson.
20 patients with rosacea were treated with a 1% metronidazole cream b.i.d. for one month. Sixteen out of twenty patients improved. The skin and intestinal microflora were studied before, during and after treatment. Topical metronidazole did not cause any significant changes in the microflora. No side effects were observed.
To achieve excellent isoelectrofocusing results with the use of Immobiline gels, the quality of the support is essential. Effects such as diffuse bands, missing protein fractions, streaking and trailing could originate from a support of inadequate quality. Two different treatments to eliminate these effects were evaluated. A washing procedure improves the band sharpness, and addition of carrier ampholytes eliminates streaking and trailing.
The total insulin consumption in 162 insulin-requiring diabetic patients was calculated from the prescriptions of purchased insulin for 1979-80. The mean daily consumption was 58.6 U, whereas the actual dose injected was 41.7 U. A mean of 1.9 doses was injected daily, which yields a loss per dose of 8.9 U (SD +/- 7.9). The dose loss was independent of age and sex and only marginally dependent on insulin dose. Visual impairment increased the loss. From a direct study of 101 patients while drawing their usual morning dose of insulin into the syringe, the following major factors underlying insulin wastage emerged: (1) expulsion of surplus insulin into the air instead of into the vial, when adjustment of the insulin dose is made; (2) use of syringes with a separate needle instead of new low-dead-space syringes; and (3) unnecessary use of 2-ml syringes for doses of insulin less than or equal to 40 U (less than or equal to 1 ml).
The accuracy of mixing two types of insulin in one syringe was studied in 41 insulin-dependent diabetic patients who prepared a mixture of two fluids (saline and sterile water) with either a disposable, 1-ml plastic syringe with a fixed needle, i.e., with a small dead space, or one equipped with a separate needle. Syringes with fixed needles delivered the two components very accurately and were associated with only slight wastage of insulin of 0.011 ml per injection. The syringe with a separate needle delivered 0.033-0.065 ml more than the intended dose of the "first insulin" and correspondingly less of the intended dose of the "second insulin," since the total dose delivered was approximately correct. The magnitude of the insulin wastage of two daily injections was calculated to be 64 ml per patient annually, which could be reduced to 8 ml per patient if fixed needles were used. It is therefore recommended that patients preparing mixtures of two insulins in the same syringe abandon syringes with separate needles.
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Cytostatic treatment of liver metastases from colorectal cancer has been of limited value. Higher drug levels in the target substances of the tumor may improve the results. It was the aim of this investigation to examine the effect of PALA (N-phosphonacetyl-L-aspartate) and D-glucosamine on the level of uracil nucleotides in the liver and in an N-methyl-N-nitrosoguanidine-induced adenocarcinoma of the colon transplanted to the liver of rats, and on the incorporation of 3H-FUrd into the acid-soluble fraction, the RNA and the DNA of the tumor and of several normal tissues. Combined treatment with PALA and D-glucosamine reduced the UTP pool in the liver and the tumor. D-glucosamine alone increased UDP-N-acetyl-hexosamine in liver tissue. Pretreatment with PALA and D-glucosamine increased incorporation of 3H-FUrd into RNA of the liver and kidney, and into the DNA fraction of the liver, but had no effect on 3H-FUrd incorporation in the tumor.
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