Search PubMed⌕ Search

Biomedical subjects

G Enders-Ruckle

Publications and source records attributed to G Enders-Ruckle.

At least 19 recordsLinked to original sources
PubMed1978

Frequency, serodiagnosis and epidemiological features of subacute sclerosing panencephalitis (SSPE) and epidemiology and vaccination policy for measles in the Federal Republic of Germany (FRG).

In the FRG, SSPE, a slow infection of the brain in children and young adults, known to be associated with a chronic measles virus infection, has an estimated incidence of 2.6 cases per million total population (61 million) and 9.7 cases per million population below the age of 19 years (16 million). In the 156 SSPE cases between 1968 and 1977 the characteristic clinical, epidemiological and serological features were found. Measles antibodies were present in the CSF and the serum titers as measured in conventional (CF--HI--IFA) and new (RIA and ELISA) tests were significantly higher than those in siblings, parents, age-matched controls as well as in patients with recent measles or after live measles vaccination. Only in children with recent wild virus infection after previous vaccination with inactivated Split measles vaccine were similar elevated serum antibody levels observed. In the SSPE cases as well as in the former group, antibodies of the IgM-class were seldom detectable and isolation of infectious measles virus from brain tissue and lymphnode derived cell cultures was rarely accomplished. The search for a co-factor or triggering agent of SSPE such as inactivated or live measles virus vaccination, concomitant childhood infection or vaccination with onset of measles or SSPE was inclusive. The seroepidemiological observation of higher frequency and titer levels of EBV- and toxoplasmosis antibody in SSPE patients as compared to siblings and parents and the suspicion that arbor virus infection may have some influence on triggering SSPE must be further substantiated. It appears that this relatively rare disease arises after an early, normal measles infection in an immunologically competent child without special genetic characteristics, mainly belonging to the lower socio-economic group, by a change of the measles virus and the immune response of the host.

Adolescent↗
PubMed1975

[Measles vaccination with split vaccines and living vaccines (author's transl)].

Two vaccination groups were observed over four years. One group received multiple preliminary vaccinations with measles split vaccine and were subsequently immunised with measles live vaccine. The second group received live vaccine only. The protection from the live vaccine, with and without the preliminary vaccination, must be considered very good, while the protection of a preliminary vaccination with split vaccine is only sufficiently effective for 1 1/2 to 2 years. All children-whether pre-vaccinated with split vaccine or not-should be protected against measles with live vaccine from the second year of life.

Age Factors↗
PubMed1975

Differences in the appearance of antibodies to structural components of measles virus after immunization with inactivated and live virus.

Children immunized with inactivated (Tween 80 and diethyl ether, TE) measles vaccine, attenuated live vaccine, or a combination of the two types were studied with regard to the production of hemagglutination-inhibiting (HAI), hemolysis-inhibiting (HLI), and nucleocapsid complement-fixing (CF) antibodies. For identification of antibodies to envelope components distinct from hemagglutinin. HLI tests were done both before and after removal of HAI antibodies with TE-treated virus antigen. Immunization with three or four doses of TE vaccine led to the production of HAI antibodies and, in some cases, of nucleocapsid CF antibodies. Non-HAI HLI antibodies were not detected. In contrast, live vaccine caused the appearance of non-HAI HLI antibodies and, in the majority of cases, nucleocapsid CF antibodies. After combined immunization with TE vaccine and attenuated vaccine, non-HAI HLI antibodies were absent from 25 of 29 children. Most children exposed to wild measles virus after immunization with TE vaccine alone developed a poorer non-HAI HLI antibody response than children who had had normal measles. The latter infections resulted in a more pronounced non-HAI HLI and nucleocapsid CF antibody response than that observed after infections with vaccine virus. An even more accentuated response involving these antibodies was seen in patients with subacute sclerosing panencephalitis. Thus the failure of inactivated measles vaccines to prevent infection may be due to the absence of an envelope component responsible for the production of non-HAI HLI antibodies.

Antibodies, Viral↗