Biomedical subjects
G Ebinger
Publications and source records attributed to G Ebinger.
Proceedings: Para-o-methylation of dopamine in human brain.
Explore the source record for details and available documents.
Dual effect of N-ethylmaleimide on agonist binding to bovine heart muscarinic receptors.
M2-Muscarinic acetylcholine receptors are identified in membrane preparations from calf heart by binding of [3H]quinuclidinyl benzilate. The alkylating reagent N-ethylmaleimide provokes two major changes in the competition binding characteristics of the agonist carbachol. At low temperature (0 degrees C), the reagent provokes a rightward shift and steepening of the competition curve in a GTP-like manner. This can be attributed to alkylation of the adenylate cyclase-regulating component Gi. At 30 degrees C, the reagent also increases the affinity of the agonist for the receptor, presumably by direct alkylation of the receptor.
Alzheimer's disease: biological diagnosis.
The authors discussed the possible clinical chemical diagnosis of Alzheimer's disease in function of the well established biochemical changes in different neurotransmitter systems.
Non-traumatic subdural hygroma.
Subdural hygroma consists of a cerebrospinal fluid-like subdural fluid collection with a low oncotic pressure in comparison with venous blood. Its etiology and pathophysiology, which may be different from other subdural fluid collections, are reviewed. We report the clinical history of a 80-year-old woman with a bilateral frontal subdural hygroma. Serial CT-scanning demonstrated a rapid increase in volume after two years of slow evolution. In our patient dehydration may have been the triggering factor. The course of non-traumatic subdural hygroma is not well known. This report illustrates that subdural hygroma can have a dramatic evolution and that therapeutic decisions in these patients should be based on repeated CT-scans.
Paroxysmal appearing palsy of epileptic origin.
Higier first reported on "Paroxysmal appearing palsy of epileptic origin". This syndrome has only rarely been described under a variety of names such as: "focal inhibitory seizures, unilateral atonic seizures, hemiparetic seizures, ictal hemiparesis". The case report we present regards a 34-year-old woman who complained of sudden loss of tone accompanied by a left-sided hemiplegia lasting for several minutes. Treatment with carbamazepine was successful in reducing the attacks as might be expected in partial seizures. An inhibitory discharge may be causative of this syndrome in agreement with Higier's original theory.
Bromide intoxication due to chronic intake of a bromide containing antacid.
Explore the source record for details and available documents.
Bromism after prolonged use of carbromal.
Most of the brominated monoureide and bromide salt containing drugs are obtainable in Belgium without prescription. Apart from the regularly encountered suicidal attempts, these drugs can also, without the intention of the patient, cause bromism . We report two cases of patients recently admitted because of bromism after prolonged use of Carbromal . Bromism now has become a rather unfamiliar condition. Therefore diagnostic and therapeutic aspects are briefly discussed. Because we dispose now, for the same indications, of more efficient and much less toxic drugs, we suggest that drugs containing a significant amount of brominated monoureides or bromide salts should be removed from the market.