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Biomedical subjects

G E Trahey

Publications and source records attributed to G E Trahey.

35 records · Page 2Linked to original sources

Two-dimensional arrays for medical ultrasound.

The design, fabrication and evaluation of two-dimensional transducer arrays are described for medical ultrasound imaging. A 4 x 32, 2.8 MHz array was developed to use new signal processing techniques for improved B-scan imaging including elevation focusing, phase correction and synthetic aperture imaging. Laboratory measurements from typical array elements showed 50 omega insertion loss of -56 dB, -6 dB fractional bandwidth of 43%, interelement crosstalk of -19 dB, and -6 dB pulse-echo angular response of 62 degrees. Simulations of pulse-echo beam plots have shown grating lobes 20 dB below the main lobe at +/- 7 degrees in the elevation direction. The complete 2-D array has been used for measurements of phase aberrations in breast, and the individual 32 element linear arrays have been used to obtain conventional B-scans. Several 16 x 16 arrays have also been developed for high speed volumetric imaging. These include 96 transmit elements and 32 receive channels. With a lambda/4 matching layer, laboratory measurements show 50 omega insertion loss of -72 dB, -6 dB fractional bandwidth of 63%, interelement crosstalk of -29 dB and -6 dB angular response of 25 degrees. Pulse-echo sensitivity was improved by 21 dB through the use of integrated circuit preamplifiers of high impedance mounted in the transducer handle. In vivo cardiac, abdominal, and obstetric B-scans with elevation focusing, as well as high speed C-scans, have been obtained with these 2-D arrays.

Equipment Design↗

Two dimensional ultrasonic beam distortion in the breast: in vivo measurements and effects.

Two dimensional arrival time data was obtained for the propagation of ultrasound across the breasts of 7 female volunteers. These profiles were extracted through the use of cross-correlation measurements and a simulated annealing process that maintained phase closure while aligning the data. The phase aberration measured in two dimensions had a larger magnitude than previously reported phase aberration measured in one dimension in the breast. A point spread function generation computer program was used to demonstrate the system response degrading effects of the measured phase aberration and the usefulness of current one dimensional phase aberration correction techniques. The results indicate that two dimensional correction algorithms are necessary to restore the system performance losses due to phase aberration.

Female↗

The impact of acoustic velocity variations on target detectability in ultrasonic images of the breast.

Experimentally obtained ultrasonic phase aberration profiles in the breast were used to investigate the impact of acoustic velocity variations on images of simulated breast lesions. The imaging properties of several phased-array transducers with varying frequencies and geometries were studied as phase error profiles of increasing magnitude were introduced. The targets studied were anechoic lesions of various sizes. The results indicate that phase aberrations significantly degrade the contrast of ultrasonic breast images, especially for high-resolution scanning systems.

Acoustics↗

A novel method for angle independent ultrasonic imaging of blood flow and tissue motion.

Tracking the speckle patterns produced by moving targets has been shown effective for angle independent imaging of blood flow and tissue motion. While speckle tracking overcomes major limitations of Doppler-based flow imaging, the computational complexity of commonly used cross correlation algorithms currently limits it to off-line studies. A much simpler algorithm for angle independent motion imaging is described in this paper. This method requires only one absolute difference operation per pixel, compared to eight operations for normalized cross correlation. Quantitative studies using speckle-generating targets translated by fixed amounts both axially and laterally indicate that the technique tracks moving speckle as accurately as correlation. Color flow images generated from clinical blood and liver data highlight the success of the technique for tracking both large and small motions in two dimensions. The algorithm's suitability for implementation in digital hardware makes possible the development of clinical instruments for angle independent ultrasonic imaging of blood flow and tissue motion in real time.

Algorithms↗

In vivo measurements of ultrasonic beam distortion in the breast.

The phase aberrations encountered by ultrasonic pulses propagating through breast tissue in twenty-two female volunteers were measured. The experiments were designed to assess the impact of these aberrations on clinical ultrasonic image quality for a variety of transducer and imaging geometries. The phase aberration profiles of a given patient were correlated with the amount of parenchymal tissue determined from that patient's mammogram. These data are useful in assessing the image quality achievable with conventional ultrasonic imaging systems, and the potential application of adaptive ultrasonic imaging systems. The results indicate that phase aberrations significantly degrade breast image quality for typical transducer frequencies and sizes.

Breast Neoplasms↗

Potential and limitations of angle-independent flow detection algorithms using radio-frequency and detected echo signals.

New techniques to estimate local blood and tissue velocities have been developed by several groups, including our own. The performance of these techniques is ultimately limited by the characteristics of ultrasonic imaging systems that determine the second-order statistics of speckle. These statistical parameters vary widely depending on the dimension of analysis in the image plane (lateral or axial) and on the echo input signal (radio-frequency or detected data). We use experiments and theory to examine these factors and describe their impact on the performance of our correlation-based technique for angle-independent tracking of blood or tissue motion. The results indicate that the second-order statistics determine the performance of our correlation-based algorithm and can be used to predict the performance of other angle-independent flow detection techniques.

Algorithms↗

A real-time adaptive ultrasonic imaging system.

The performance of an experimental, adaptive, phased array imaging system in improving the quality of abdominal organ images in healthy volunteers was assessed. Trials were conducted under usual clinical imaging conditions and when phase aberrators of known shape and magnitude were introduced into the imaging system. The system, which uses local target brightness as a quality factor, was able to improve clinical image quality when aberrators introduced externally were present and had a negligible effect on image quality when they were not. On several of the volunteers, the phase aberrations were measured directly across the abdomen. The implications of these results for the future clinical application of adaptive imaging systems and the future system modifications are reported.

Adult↗

Phase aberration correction in medical ultrasound using speckle brightness as a quality factor.

Medical ultrasonic images are degraded by tissues with inhomogeneous acoustic velocities. The resulting phase aberration raises the off-peak response of the imaging system's point spread function (PSF), decreasing dynamic range. In extreme cases, multiple images of a single target are displayed. Phase aberration may become a limiting factor to image quality as ultrasonic frequency and aperture size are increased in order to improve spatial resolution. A method is proposed to correct for unknown phase aberration, which uses speckle brightness as a quality factor. The phase delays of a phased array transducer are modified, element by element, to maximize mean speckle brightness in a region of interest. The technique proposed is analogous to the correction technique used by Muller and Buffington [J. Opt. Soc. Am. 64 (9), 1200-1209 (1974)] to adaptively focus incoherent optical telescopes. The method is demonstrated using a computer model with several different simulated aberration profiles. With this model, mean speckle brightness is calculated using the two-dimensional PSF. Experiments have also been conducted in which speckle brightness is shown to increase as the phase delays of an ultrasonic scanner are modified in order to compensate for a rippled aberrating layer made of silicone rubber. The characteristics of the proposed method, and the possibility of employing it clinically to correct for unknown inhomogeneities in acoustic velocity, are discussed.

Computer Simulation↗

Angle independent ultrasonic blood flow detection by frame-to-frame correlation of B-mode images.

We have previously reported initial clinical results of a novel blood velocity imaging technique utilizing a two-dimensional correlation search applied to consecutively acquired echoes. In this paper, we describe both the physical principles underlying this technique and test tank experiments which define its performance under a variety of conditions. The results indicate that, unlike Doppler flow imaging systems, this technique defines the flow velocity vector in two dimensions and is not subject to aliasing.

Blood Flow Velocity↗

Properties of acoustical speckle in the presence of phase aberration. Part I: First order statistics.

The first order statistical properties of acoustical speckle patterns are studied as a function of several types of random and structured phase error. Such errors may arise from tissue velocity inhomogeneities or limitations in the acoustical imaging system. In this paper, we review the theory describing the statistical properties of speckle, describe a computer model which predicts the mean speckle brightness in the presence of phase aberrations, and report experiments in which we measure the effect of these aberrations on speckle brightness and variance. We find that the average speckle brightness is significantly reduced by even mild phase aberrations. The phase aberrations studied include focal point errors, random phase errors, and structured errors. Good agreement is found between experiment and computer simulation. We then discuss the implications of these results for imaging through aberrating media, tissue characterization and phase compensation methods.

Humans↗

Properties of acoustical speckle in the presence of phase aberration. Part II: Correlation lengths.

In recent years, analysis of the second order statistics of ultrasound speckle has led to accurate prediction and measurements of the average speckle size in the transducer focal zone. In this paper, that work has been extended to the average speckle size as determined by the normalized autocovariance in the presence of transducer phase aberrations. In general, a phase aberration causes a narrowing of the main lobe of the normalized autocovariance in the lateral direction. However, the lateral speckle autocovariance also showed significant side lobes in the presence of phase aberrations, indicating that individual speckles in a region of interest are not independent but are correlated so that less information is present for the task of signal detection when a transducer phase aberration exists. The same evidence of correlated speckle was found in the near field of a transducer in the region of fine speckle texture. This explanation satisfies the quandary of poor detectability in the near field region where the speckle is fine but the lateral resolution is quite degraded. The axial speckle in the presence of phase aberrations showed a small increase in main lobe widths and no evidence of side lobes. Beginning in 1978, the analysis of the second order statistics of speckle images for the purpose of spatial compounding led to accurate measurement and prediction of the cross-correlation curve as a function of transducer aperture translation for purposes of spatial compounding. In this paper, that work has been extended to the presence of transducer phase aberrations. The existence of transducer phase aberrations causes significant increases in the rate of decorrelation of speckle interference patterns as a transducer is translated. This indicates that spatial compounding will result in quite significant improvements in area-wise SNR and low contrast lesion detection for the case of severe random aberrators or focal point errors.

Humans↗

Phased array ultrasound imaging through planar tissue layers.

Conventional ultrasound imaging devices are designed based on the assumption of a homogeneous tissue medium of constant acoustic velocity = 1540 m/sec. However, the body consists of tissue layers of varying thicknesses and velocities which range from 1470 m/sec in fat to 3200 m/sec in skull bone. Refraction effects from these layers degrade ultrasound image quality. In this paper, pulse-echo ultrasound imaging is modeled as imaging an organ of interest through an intervening planar tissue layer, such as liver through fat in the abdomen or brain through skull bone in the adult head. Refraction effects from planar tissue layer interfaces are analyzed using Snell's law and measured using phantoms. We also introduce an on-line phased array correction technique based on planar tissue layers to restore ultrasound image quality. We conclude that fat/organ planar interfaces do not degrade image quality significantly. However, refraction effects at a skull/brain planar interface degrades resolution and target acquisition and introduces geometric distortion. Our plane layer phased array correction technique significantly improves image quality in phantoms through lucite aberrators and improves adult cephalic ultrasound image quality when used through the top of the adult skull. The correction technique is robust even in the presence of inaccurate estimates of skull thickness.

Adipose Tissue↗

A quantitative approach to speckle reduction via frequency compounding.

Coherent speckle is a source of image noise in ultrasonic B-mode imaging. The use of multiple imaging frequencies has been suggested as a technique for speckle contrast reduction. This technique involves the averaging of images whose speckle patterns have been modified by a change in the spectrum of the transmitted or received acoustical pulse. We have measured the rate of this speckle pattern change in ultrasonic images as a function of the change in center frequency of the transmitted acoustical pulse. This data is used to quantitatively describe the trade-off of resolution loss versus speckle reduction encountered when frequency compounding is employed and to derive the optimal method of frequency compounding. These results are then used as a basis for describing the overall advisability of frequency compounding in ultrasonic imaging systems. Our analysis indicates that simple frequency compounding is counterproductive in improving image quality.

Humans↗

Three-dimensional flow images by reconstruction from two-dimensional vector velocity maps.

A method for constructing three-dimensional images of flow is described. The technique involves the acquisition of numerous closely spaced planes, each comprised of a map of the two-dimensional velocities measured in that plane. Each such vector velocity map is formed by tracking the motion of small regions of ultrasonic speckle between two ultrasonic acquisitions separated by a short time interval. In contrast to current Doppler velocity methods, this technique measures both the axial and lateral components of flow and is not subject to aliasing. The resulting series of two-dimensional vector velocity maps is then combined into a three-dimensional data set, which can be manipulated with appropriate software to yield quantitative three-dimensional displays of the flow within the interrogated volume. In this article we present such images obtained from measurements of in vitro laminar flow in a vessel, as well as a free jet phantom. The results allow comprehensive visualization of the three-dimensional flow characteristics, indicating promise for more complete and quantitative clinical assessment of blood flow.

Blood Flow Velocity↗