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Biomedical subjects

G E Thompson

Publications and source records attributed to G E Thompson.

At least 127 records · Page 7Linked to original sources
PubMed1968

Adipose tissue and heat production in the new-born ox (Bos taurus).

1. A histological examination of adipose tissue from 1- and 6-day-old calves showed a structure typical of white adipose tissue and no evidence of brown adipose tissue.2. Infusion of noradrenaline (1.0 mug/kg.min I.V.) into 1-to 6-day-old calves affected heart rate and respiratory rate but did not increase heat production, rectal temperature, skin temperature or skin evaporative loss.3. Cold exposure led to shivering and an increased oxygen consumption in the 6-day-old calf.4. Blood samples taken from 6-day-old calves in the cold (-1 degrees C) appeared to have a higher proportion of unesterified fatty acids in the total blood lipid than samples taken in an environment of 20 degrees C, but no change in fatty acid composition was found.5. It has been concluded that there is no non-shivering thermogenesis in the young calf.

Adipose Tissue↗
PubMedDate not supplied

Commentary: neurotoxicity of local anesthetics--an issue or a scapegoat?

BACKGROUND AND OBJECTIVES: To evaluate the etiologies of cauda equina syndrome (CES) and transient radicular irritation (TRI) or transient neurologic symptoms (TNSs) following hyperbaric spinal anesthesia. METHODS: A review of recent (since 1991) and prior (since 1941) investigations regarding CES and TRI (TNSs) was conducted. RESULTS: Recent publications fail to recognize significant prior information regarding CES and TRI (TNSs). CONCLUSIONS: Cauda equina syndrome is, in all probability, explainable. Further investigation to pinpoint the etiology of TRI (TNSs) is needed.

Anesthesia, Spinal↗
PubMedDate not supplied

Incendiary characteristics of endotracheal tubes with the carbon dioxide laser. An experimental study.

The ignition characteristics of the American Hospital, Portex, polyvinyl chloride, and red rubber tracheal tubes commonly available have been evaluated using a standard carbon dioxide laser. The added hazard of the increased combustibility of the impregnated line on endotracheal tubes and the hazard of commonly utilized anesthetic or lubricating materials are discussed. The safety limits which experimentally, indicate levels of energy and laser burst time which seem to preclude the hazard of ignition are outlined. The potential danger of postburn bronchiolitis is noted, along with appropriate treatment.

Bronchitis↗
PubMedDate not supplied

Abdominal pain and alcohol celiac plexus nerve block.

Alcohol celiac plexus nerve blocks were done in 100 patients, of whome 97 had intractable abdominal pain from cancer. In most cases, an initial diagnositc block with bupivacaine was followed by the therapeutic block performed by injecting 50 ml of 50 percent ethyl alcohol. Good to excellent pain relief occurred in 94 percent of patients. Fourteen blocks were repeated for recurrent pain. Life duration ranged from 2 days to 14 months after the block. Complications and side effects were infrequently seen but did include a 10 percent incidence of postural hypotension and 1 case of partial leg paralysis. This block is remarkably safe as well as effective and should be employed more frequently.

Abdomen↗
PubMedDate not supplied

Bupivacaine: a review of 11,080 cases.

Bupivacaine (Marcaine) hydrochloride, a long-acting local anesthetic drug, was used in concentrations of 0.25, 0.5, or 0.75 percent with and without a vasoconstrictor, in amounts ranging from 25 to over 600 mg, for caudal, epidural (peridural), or peripheral nerve block for 11,080 surgical, obstetrical, diagnostic, or therapeutic procedures. Onset of anesthesia occurred in 4 to 10 minutes and maximum anesthesia in 15 to 35 minutes. Concentrations of 0.25, 0.5, and 0.75 percent consistently produced complete sensory anesthesia of the integumentary and musculoskeletal systems. With 0.25 and 0.5 percent, motor blockade ranged from minimal to complete. In intra-abdominal surgery, only 0.75 percent consistently produced profound muscle relaxation. Fifteen systemic toxic reactions occurred, but no untoward sequelae resulted from them. One inadvertent subarachnoid injection of 110 mg resulted in a total spinal block with an uneventful recovery.

Analgesia↗
PubMedDate not supplied

Multidisciplinary patient management by means of a high social risk screening tool.

OBJECTIVE: The long-term goal in this study was for the Memorial Hospital of Salem County, Inc (MHSC), to create a seamless system of continuity of care for patients. This continuity of care begins before patients require acute admission through the hospital course and extends beyond discharge and into the post-hospital setting or alternate care situation. DESIGN: In a retrospective study in 1993, through the first 6 months of 1994, it was discovered that MHSC patients experienced a longer-than-average Medicare length of stay than was seen in other hospitals. MHSC embarked on a program to reduce discharge planning request time to the social work and home care departments by using a patient screening system that began at the time of admission. The nursing, social work, and home care departments collaboratively designed a system that allowed for immediate transfer of vital discharge planning information to the social work and home care departments at the time of the patient's admission. A tool was jointly developed called the multidisciplinary patient management record. RESULTS: The benefits of this process far exceeded the cost of implementing the tool. The average skilled nursing facility length of stay decreased below the national average by almost one full day. Patients experienced earlier access to social service intervention: discharge planning needs were identified more accurately; and the social services and home care departments' productivity rose because they could anticipate problems before a crisis arose. CONCLUSIONS: Critical to the success of this overall effort was not designing the new tool, but integrating the tool into a reengineered multidisciplinary patient management process.

Continuity of Patient Care↗
PubMedDate not supplied

Control of intestinal flora in animals and humans: implications for toxicology and health.

The importance of the intestinal flora in disease management is discussed, and apparent relationships noted in experimental and clinical reports are reviewed. It is suggested that investigation of the influence of the intestinal flora upon body organs and systems would productively lay the groundwork for abetter understanding of certain synergistic mechanisms.

Animals↗
PubMedDate not supplied

Bupivacaine compared with etidocaine for vaginal delivery.

A comparison of 0.5 percent etidocaine with 0.25 and 0.5 percent bupivacaine, using continuous (intermittent) caudal block in 60 vaginal deliveries, showed the latter two solutions to be the agents of choice. All solutions contained a final concentration of 1:2000,000 epihephrine. In 40 parturients given either 0.25 or 0.5 percent bupivacaine, all had pain relief after the initial dose, while 5 of 20 given etidocaine required a refill dose within 30 to 50 minutes for complete pain relief. The duration of action of the initial dose with both concentrations of bupivacaine was longer than that of etidocaine. The degree of motor blockade with 0.5 percent etidocaine was greater than with 0.5 percent bupivacaine, and with 0.5 percent concentrations of either etidocaine or bupivacaine was greater than with 0.25 percent bupivacaine. The duration of motor blockade of 0.5 percent etidocaine and bupivacaine was comparable. The duration of motor blockade of the 0.25 percent concentration of bupivacaine was shorter than with the 0.5 percent concentration of both etidocaine and bupivacaine; and with both bupivacaine concentrations the duration of sensory anesthesia in the extremities was longer than motor blockade; with etidocaine, the opposite occurred.

Acetanilides↗