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Biomedical subjects

G E Smart

Publications and source records attributed to G E Smart.

29 records · Page 2Linked to original sources
PubMed1981

The detection of DNA tumour virus-specific RNA sequences in abnormal human cervical biopsies by in situ hybridization.

We have used the technique of in situ nucleic acid hybridization and autoradiography of thin frozen sections of human tissue to search for virus RNA sequences in human cervical tumours. Of cervical biopsies with abnormal cytology, 67% bound herpes simplex virus type 2 (HSV2) 3H-labelled DNA probes and 39% bound adenovirus type 2 (Ad2) 3H-labelled DNA probes, whereas control experiments with phage lambda 3H-labelled DNA probes, under the same conditions, bound to only 7% of cases. In contrast, normal cervical biopsies bound the three probes in only 23%, 17% and 8% of cases respectively.

Adenoviruses, Human↗
PubMed1979

A renal biopsy study in toxaemia of pregnancy.

Renal biopsy specimens from 11 women with severe pre-eclamptic toxaemia were examined by light and electron microscopy linked with immunofluorescence and immuno-electron microscopy. The part played by the mesangium in causing capillary loop thickening is stressed, and the progress of this 'strangulation' is illustrated. In contrast to the findings of most previous authors, IgM was demonstrated by direct immunofluorescence in all biopsy specimens, and its presence and site within the glomerulus were shown by immuno-electron microscopy in three cases.

Adult↗
PubMedDate not supplied

Intraplacental choriocarcinoma: a case report.

A recent paper has again drawn attention to the occurrence of intraplacental choriocarcinoma. We present a similar case in which a small intraplacental choriocarcinoma was identified after delivery of a full-term stillborn fetus. Interpretation of this lesion was influenced by the presence of normal villi and its full significance appreciated only after diagnosis of choriocarcinoma in the mother. This case presents histological proof that choriocarcinoma may arise from an otherwise normal placenta.

Adult↗
PubMedDate not supplied

Cisplatinum and prednimustine, an active regimen for advanced epithelial ovarian cancer.

80 patients with advanced epithelial ovarian carcinoma were treated for 6 months with cisplatinum and prednimustine following initial surgery. Response to treatment was assessed by second-look surgery. The objective response rate was 69% with 38% achieving a complete response for up to 55 months. The toxicity of this regimen was acceptable. Statistically, de-bulking or partial de-bulking had a significant beneficial effect on the likelihood of a complete response. The best survival figures were associated with maximum de-bulking. The combination of cisplatinum and prednimustine is a new and active regimen for operable advanced epithelial ovarian carcinoma.

Adult↗