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Biomedical subjects

G E Rose

Publications and source records attributed to G E Rose.

At least 91 records · Page 5Linked to original sources
PubMed1992

Dermofat grafts to the extraconal orbital space.

Dermofat grafts were placed in the upper or lower lid sulci in 35 subjects, aged from 11 to 59 years, to improve the cosmesis of volume deficient sockets or prevent tissue adhesion. Volume enhancement and cosmetic improvement were achieved in 31 patients, in whom useful vision was present in 13/22 after previous trauma, in 4/4 with facial clefting, and in 3/3 with orbital or facial fat atrophy. Grafts were used successfully in nine patients to prevent scar formation after division of adhesions between the eyelids or levator muscle and the orbital margins. A reduction of the bulk of upper-lid grafts was required in three cases; histopathology of the excised fat showed relatively minor degrees of inflammation, atrophy, and fibrosis.

Adipose Tissue↗
PubMed1991

Isolated peripheral nerve sheath tumours of the orbit.

Fifty-four cases of peripheral nerve sheath tumours within the orbit are reviewed. Benign neurilemmomas or neurofibromas occurred in 93% of patients and had an equal incidence. There was a family history or other signs of systemic neurofibromatosis in one-quarter of those with solitary neurofibromas, but in none of the patients with neurilemmoma. Symptoms and signs were generally those of an orbital mass lesion and pain or sensory loss was unusual, occurring more frequently with malignancy. Within the orbit, most peripheral nerve sheath tumours affect the first division of the trigeminal nerve and extension of some tumours through the superior orbital fissure limits their surgical resection. Despite incomplete resection of some tumours, with up to 23 years follow-up there have been no recurrences requiring further surgery. A postoperative sensory deficit occurred in only 32% of patients with benign neurilemmomas and 72% with neurofibromas.

Adolescent↗
PubMed1991

Periorbital necrotising fasciitis.

Three cases of periorbital necrotising fasciitis are described, one occurring in a three-year-old child. The cases in adults required debridement of necrotic tissue, in one of whom there was extensive disease involving the face and orbital fat. It is probable that the early stages of this condition are under-recognised; the importance of early signs and intensive treatment of this life-threatening disease are illustrated.

Child, Preschool↗
PubMed1991

Jones' lacrimal canalicular bypass tubes: twenty-five years' experience.

The results after implantation of Lester Jones canalicular bypass tubes in 326 eyes (310 patients) are reviewed. The bypass tubes were implanted after canalicular obstruction from a variety of causes, of which post-herpetic or post-traumatic obstruction accounted for one-half of all cases. With up to 23 years' follow-up, replacement of the bypass tube was needed in 142 (44%) patients, the majority after spontaneous loss. The median interval to first replacement may be estimated as about ten years for spontaneous loss and five years for all causes. Despite complications and the need for further surgery in many patients, most patients (91%) were pleased with the functional result of surgery. The principles, techniques and complications of lacrimal canalicular bypass surgery are presented and the long-term care of bypass prostheses is discussed.

Adolescent↗
PubMed1991

Anisocoria in unilateral ophthalmic disease.

Pupillary diameters in the affected and unaffected eyes of 327 patients with uniocular red eye were assessed during fixation of a distant target. The mean pupillary diameters were similar in the unaffected eyes in each of eight diagnostic groups, but were significantly different (F = 3.84, p less than 0.001) in the diseased eyes. With corneal abrasions (p less than 0.001), marginal keratitis (p less than 0.05), and acute anterior uveitis (p less than 0.001) the mean pupillary diameter for the affected eye was significantly smaller than that of the unaffected eye. The observed differences of pupillary diameter probably reflect the role of neuronal and autocoid mechanisms in the unilateral control of pupillary size.

Adolescent↗
PubMed1991

Orbital xanthogranuloma in adults.

The onset of periorbital xanthogranuloma in adults is rare and may be accompanied by haematological abnormalities and malignancy. The appearance of the eyelid lesions is virtually diagnostic, producing readily recognisable diffuse, yellow plaques, and affected patients should be investigated and reviewed regularly for systemic disease. Three cases are described, in which periorbital cutaneous plaques were associated with abnormal tissues in the superior part of the orbit; these abnormal tissues caused displacement or restricted movement of the globe or upper eyelid. The possibility that two cases represent a necrobiotic type of xanthogranuloma is presented. Nine years after the onset of xanthogranuloma one patient developed non-Hodgkin's lymphoma. A multiple-drug regimen of systemic chemotherapy, given for lymphoma, caused a marked clinical reduction in the periorbital xanthogranuloma.

Adult↗
PubMed1990

Immunoglobulins in paired specimens of vitreous and subretinal fluids from patients with rhegmatogenous retinal detachment.

Evidence suggests that there is a net movement of fluid through the retinal break in eyes with rhegmatogenous retinal detachment, this net movement being directed from the vitreous humour into the subretinal space. However, it remains uncertain how much fluid exchange occurs in both directions across such breaks. The concentration ratios of IgG/IgM or IgA/IgM, derived from assay of immunoglobulins in vitreous humour, subretinal fluid, and serum from a group of 19 such patients, suggest a lack of free, two-directional, fluid movement across the retinal break. Furthermore the IgG/IgM ratios for the two intraocular fluids were significantly greater than that of serum, this suggesting that these intraocular fluids are formed, at least in part, by a selective transduction of serum.

Adolescent↗
PubMed1990

The volume-deficient orbit: clinical characteristics, surgical management, and results after extraperiorbital implantation of Silastic block.

The surgical techniques and results after extraperiorbital implantation of Silastic on the orbital floor of 70 patients are reviewed. In 11 patients the implant was through a subciliary approach and in 59 through an inferolateral cantholysis. The inferolateral cantholysis, a simplification of the McCord and Moses approach to the orbital floor, is particularly suited to this application. The implanted Silastic was retained in 66 patients, with an average follow up of 3.5 years (range less than 1 to 9.5 years), though six required surgery to debulk the anterior end of the implant. Further surgery was required in 27 patients, this generally being to correct the position of either the upper or the lower lid. Volume enhancement was effective in most cases, there being a significant reduction in the degree of recession of the prosthesis and the depth of the unsightly sunken sulci of the upper and lower lids. The mobility of the orbital contents, the prosthesis, and the upper lid was not improved.

Adolescent↗
PubMed1989

Silicone tubes in glaucoma surgery: the effect of technical modifications on early postoperative intraocular pressures and complications.

One hundred and nineteen eyes with glaucoma were treated by implantation of silicone rubber tubes draining either to encircling inverted gutters (92 eyes) or to integral plates sutured at the equator of the globe. The occurrence of persistent choroidal effusion was related significantly (S less than 0.01) to post-operative hypotony and choroidal haemorrhage appeared to occur during periods of ocular hypotony. This paper describes our surgical modifications to overcome these problems. A one-piece integral tube and plate with a slit-valve mechanism designed to regulate post-operative intraocular pressure had a very variable response in 27 eyes, with mean pressures similar to those after unligated tube and gutters. Ligation of the tube in 34 eyes caused significantly higher mean intraocular pressures on the first two days after surgery than that in 43 eyes without ligation and the incidence of ocular hypotony (less than 7 mmHg) was significantly lower after ligation. However, five eyes with ligated tubes required operative release of the suture because of uncontrollably raised intraocular pressures. Venting of the drainage tube on the anterior chamber side of the occlusive ligation in 15 eyes caused fewer cases of raised post-operative intraocular pressures, but also a moderate increase in the frequency of ocular hypotony. At present a combination of occlusive ligation and a venting stab into the drainage tube in a one-piece tube and plate system appears to be the best design for avoiding short-term ocular hypotony whilst achieving long-term pressure control.

Adolescent↗
PubMed1987

The Hudson-Stahli line. I: An epidemiological study.

The overall prevalence of Hudson-Stahli line in a group of 550 subjects was 65 per cent with bilateral involvement and a further 4 per cent with unilateral involvement; analysis of two subgroups, with either blue/grey iris colour or with brown/green colour, suggested that the incidence is slightly higher in the latter group, particularly in the third to fifth decades. Irrespective of iris colour, the incidence rises with age. Both the length and the density of the line increase with age. For a given age, brown/green eyes have longer lines than blue/green eyes, but similar densities. Concordance of length and density between the right and left eyes of a pair is seen in about 80 per cent of subjects.

Adolescent↗
PubMed1987

The Hudson-Stahli line. II: A comparison of properties in eyes with and without long-term contact lens wear.

The eyes of 98 long-term contact lens wearers and 342 subjects not wearing contact lenses were examined for the presence of Hudson-Stahli lines, using slit-lamp biomicroscopy. The period of contact lens wear ranged from 2 to 25 years, all subjects using contact lenses for refractive reasons only. The incidence of Hudson-Stahli lines in contact lens wearers was not significantly different from that of control subjects in the same decades. Contact lenses appear, however, variably to alter the characteristics of the Hudson-Stahli line. Results from a group of 4 unilateral lens wearers, from 94 bilateral lens wearers and from studies of the morphology of the line suggest that contact lens wear is associated with a relative reduction of length and density of the line and also with a broadening and, more rarely, displacement of it. In eyes with brown or green irides, the attenuation of length and density by contact lens wear obscures the normal increases seen with age; in this subgroup of contact lens wearers, both factors appear to be almost constant from the third to sixth decades of life.

Adolescent↗
PubMed1987

The Hudson-Stahli line. III: Observations on morphology, a critical review of aetiology and a unified theory for the formation of iron lines of the corneal epithelium.

Observations as to the morphology, position and orientation of the Hudson-Stahli line are presented, based on the slit-lamp biomicroscopic examination of the eyes of six hundred and forty-four subjects. The origin of the pigments in the Hudson-Stahli zone and other corneal epithelial lines is reviewed, the evidence for either tear film dynamics or epithelial dynamics influencing the typical configuration is discussed and a unified theory for the formation of corneal iron lines is presented.

Cornea↗
PubMed1986

Clinical assessment of corneal endothelial cell density: an original system of grading using a slit-lamp biomicroscope.

An original system of grading of the corneal endothelial specular reflection, as assessed with a Haag-Streit 900 slit-lamp biomicroscope, has been shown to have a very highly significant relation to the endothelial cell density measured by contact specular photomicroscopy. The grading, though subjective and therefore not a substitute for the detailed record of photomicroscopy, is readily applicable to clinical practice and is a useful method of comparing and recording endothelial cell densities when assessed by the same observer. The intraobserver, but not the interobserver, variability has been examined, and the theoretical aspects of the grading system and a clinically applicable interpretation of the grading are presented.

Aged↗