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Biomedical subjects

G E Packe

Publications and source records attributed to G E Packe.

35 records · Page 2Linked to original sources
PubMed1987

Blood fuel metabolites in asthma during and after progressive submaximal exercise.

Ten male stable asthmatic subjects and 10 matched control subjects performed a progressive exercise test on a treadmill to 85% of their predicted maximum heart rate. Blood lactate, pyruvate, hydrogen ion, glucose, alanine, glycerol and total ketone body concentrations were measured at frequent intervals during and up to 60 min after exercise. Carbon dioxide production, oxygen consumption, ventilation, respiratory exchange ratio and oxygen saturation were also measured during and up to 10 min after exercise. There were no significant differences between the asthmatic and control subjects in levels of carbon dioxide production, oxygen consumption and ventilation. The respiratory exchange ratio was greater in the asthmatic subjects during recovery from exercise (P less than 0.05). No changes in oxygen saturation were observed during exercise in either group. In both asthmatic and control subjects, lactate, pyruvate, hydrogen ion, alanine and glycerol concentrations showed an increase from baseline levels, reaching maximum levels up to 10 min after exercise and returning to baseline within 1 h after exercise. Total ketone body concentrations decreased during exercise. There were no significant differences between the asthmatic and control subjects in the concentration of any metabolite over the study period. These data indicate that fuel metabolism during and after short-term progressive exercise is similar in stable asthmatic and normal subjects.

Adult↗
PubMed1986

Comparison of right ventricular weight at necropsy in interstitial pulmonary fibrosis and in chronic bronchitis and emphysema.

The ventricular weights in 43 patients with interstitial pulmonary fibrosis were retrospectively compared with those in 172 patients with emphysema and chronic bronchitis. The mean right ventricular weight of patients with interstitial pulmonary fibrosis and those with emphysema and chronic bronchitis was 85.5 g (SD 23.2) and 88.8 g (34.3), respectively. Thirty five patients (81%) with interstitial pulmonary fibrosis had a right ventricular weight over 65 g compared with 124 (72%) of those with emphysema. Fifty three per cent of both those with interstitial pulmonary fibrosis and those with chronic bronchitis and emphysema had a right ventricular weight greater than 80 g. Differences between the two groups were not significant. These results suggest that the prevalence of right ventricular hypertrophy and pulmonary hypertension in interstitial pulmonary fibrosis is similar to that found in chronic bronchitis and emphysema.

Aged↗
PubMed1986

Large lung bullae in sarcoidosis.

Large lung bullae are a rare manifestation of pulmonary sarcoidosis. Of three patients with this complication, all had pulmonary infiltrates at presentation and two had bilateral hilar adenopathy. Hypercalcaemia developed during the course of the illness in all three patients. In each case the bullae had developed within four years of the diagnosis of sarcoidosis. In one woman a bulla resolved almost completely after it had become infected.

Adult↗
PubMed1985

Asthma outbreak during a thunderstorm.

An outbreak of acute asthma occurred in Birmingham and the surrounding area on July 6 and 7, 1983. In most patients symptoms began at the time of sudden climatic changes associated with a thunderstorm. Air pollution was not a factor. The large and sudden increase in numbers of airborne fungal spores, especially Didymella exitialis and Sporobolomyces, around the time of the outbreak suggests that they may have been partly contributory, although a direct causal effect has not yet been established.

Air Microbiology↗
PubMed1985

Subphrenic abscess: a complication of lobar pneumonia.

A patient presented with a pneumococcal lobar pneumonia and later developed a subphrenic abscess. Peritonitis and intra-abdominal abscess formation should be remembered as a rare cause of delayed recovery from lobar pneumonia.

Blood Transfusion↗
PubMed1984

A dose-response and duration of action assessment of a combined preparation of fenoterol and ipratropium bromide (Duovent).

The dose-response relationships of a combination of the selective beta adrenergic agonist, fenoterol, and the synthetic anticholinergic drug, ipratropium bromide, were studied. In an open cross-over assessment, 20 patients with evidence of reversible airways obstruction inhaled 2, 4, 6 or 8 puffs from a metered dose inhaler, containing 100 micrograms fenoterol and 40 micrograms ipratropium bromide per puff, administered according to a randomization schedule, on four non-consecutive days. Before, and at intervals up to eight hours after inhalation FEV1, FVC, pulse and blood pressure were measured. Immediate and prolonged bronchodilatation followed each dose. The overall analysis of the FEV1, and FVC showed little difference between 2, 4 and 6 puffs. The highest dose, 8 puffs, was more effective, but associated with an increased incidence of side effects.

Adult↗
PubMedDate not supplied

Bone density in asthmatic patients taking inhaled corticosteroids: comparison of budesonide and beclomethasone dipropionate.

We assessed bone mineral density (BMD) in 20 asthmatics who had been taking inhaled budesonide (BUD) (median daily dose 800 micrograms) for over a year, 13 of whom had taken previous courses of systemic steroids. Their results were compared with those of 20 patients receiving inhaled high-dose beclomethasone dipropionate (BDP) (median daily dose 1,000 micrograms), all of whom had received previous courses of systemic corticosteroids, and with those of 17 mild asthmatics who had never taken either inhaled or systemic steroids. Mean (standard deviation) (SD)) BMD in the patients taking BUD was 139.5 (28.6) mg/ml. This was significantly lower (p < 0.05) than in the control patients who had never taken inhaled or systemic steroids (160.4 (27.4) mg/ml). Mean BMD in the patients taking BUD did not differ significantly from that observed in patients taking BDP (127.5 (22.6) mg/ml). Although the reduction in BMD in the asthma patients taking regular high-dose BUD could have been due to previous courses of corticosteroid, the magnitude of bone loss is similar to that seen in patients taking high-dose inhaled BDP and intermittent corticosteroids.

Administration, Inhalation↗