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Biomedical subjects

G E Ehrlich

Publications and source records attributed to G E Ehrlich.

At least 55 records · Page 3Linked to original sources
PubMed1982

Diagnosis and management of rheumatic diseases in older patients.

The young and the old move differently, yet there are standards of normality for each. Chronic diseases of the joints, with their concomitant stiffness and pain, cause more fear of an impending crippling disability and loss of life space and content than actual pain and stiffness. Thus, a prime goal of physicians who treat patients who have chronic musculoskeletal diseases is to allay this fear by correcting misconceptions about arthritic diseases. Drug therapy can relieve the pain and stiffness and control the inflammation that causes these symptoms. Important aspects of rheumatoid arthritis, osteoarthritis, and polymyalgia rheumatica, a closely related disorder, are emphasized to point out the difficulty of the differential diagnosis of these diseases in older patients and the need for realistic therapeutic goals. A combination-drug regimen, with a nonsteroidal anti-inflammatory drug for alleviation of pain and control of inflammation and an analgesic drug for relief of residual pain, is the drug therapy of choice within the context of a total management program. By addressing both the physiologic and the psychologic aspects of musculoskeletal disease, physicians can help patients lead more active and useful lives.

Aged↗
PubMed1981

Rubens and the question of antiquity of rheumatoid arthritis.

Analysis of the hands in paintings attributed to Peter Paul Rubens during the last 30 years of his life seems to show progressive rheumatoid arthritis. Not only does this suggest that rheumatoid arthritis was present at the time, 200 years before some modern authors are willing to date its appearance, but also that Rubens or a major and consistent collaborator suffered from the disease.

Art↗
PubMed1981

DNA in synovial fluid and the circulation of patients with arthritis.

DNA levels were measured in synovial fluids and sera of 106 patients with rheumatoid arthritis (RA), osteoarthritis (OA), gout, pseudogout, and posttraumatic arthritis (TRA). In synovial fluids, the highest concentration was found in rheumatoid arthritis (mean +/- SE 18 +/- 3 microgram/ml for seropositive and 9 +/- 1 microgram/ml for seronegative variants), gout and pseudogout (17 +/- 3 microgram/ml). In contrast, the levels in patients with OA or acute TRA were very low: 0.8 +/- 0.1 microgram/ml an 1.1 +/- 0.2 microgram/ml, respectively. The differences between the means of the first disease group and OA or TRA is statistically significant. A similar pattern was observed for DNA levels in the circulation: in rheumatoid arthritis, the mean concentration was 135 +/- 28 ng/ml and 164 +/- 39 ng/ml for seropositive and seronegative RA, respectively. Again the levels in OA and TRA were much lower, 52 +/- 18 ng/ml and 0 ng/Ml, respectively. The latter are not significantly different from the mean levels of 95 normal, healthy controls (14 +/- 3 ng/ml), whereas the concentration of DNA in the serum of RA patients is significantly higher than in OA, TRA, or normal controls. Serial determinations of DNA and other criteria of disease activity (leukocytes and protein levels in synovial fluid, blood sedimentation rate) in individual patients revealed a strong correlation of elevated values with active episodes. THe results suggest that these parameters reflect tissue damage.

Arthritis↗
PubMed1980

Rheumatology.

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Rheumatology↗
PubMed1980

Choline magnesium trisalicylate versus ibuprofen in rheumatoid arthritis.

A double-blind study compared choline magnesium trisalicylate (Trilisate tablets, Purdue Frederick) (CMT) and ibuprofen (IPF) in the treatment of rheumatoid arthritis. The seven-week trial in 134 ambulatory patients, of whom 68 received CMT and 66 received IPF, was conducted as a multicentre study. Both CMT and IPF were highly effective in reducing significantly all symptoms that had worsened following the discontinuance of previous therapy. The anti-inflammatory effect of CMT produced a significantly (P less than 0.05) greater reduction in the number of swollen joints, compared to IPF, in patients completing all required visits. Further clinical study will be required before the full clinical significance of this observation emerges. Incidence of adverse effects for each drug did not differ significantly.

Adult↗
PubMed1980

Salivary gland dysfunction in systemic lupus erythematosus and rheumatoid arthritis. Diagnostic importance.

Salivary scintigraphy employing radionuclides has proved to be an accurate, reproducible method for demonstrating salivary gland involvement in Sjögren's syndrome. A prospective study was undertaken of 24 consecutive patients bearing a diagnosis of systemic lupus erythematosus (SLE), 78 consecutive patients bearing a diagnosis of classic or definite rheumatoid arthritis, and 18 control patients. Clinical of Sjögren's syndrome did not necessarily correlate with abnormal scintiscans. Extensive involvement, with greatly abnormal scintiscans (class 3 and 4), was found most consistently in patients who had SLE and who were seronegative for rheumatoid factor Salivary gland scintigraphy may ultimately serve as an adjunctive procedure for the diagnosis of this disease.

Adolescent↗
PubMed1979

Rheumatology.

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HLA Antigens↗