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Biomedical subjects

G E Ehrlich

Publications and source records attributed to G E Ehrlich.

At least 19 recordsLinked to original sources
PubMed1992

Racemic mixtures: harmless or potentially toxic?

Issues involved in the development and evaluation of racemic drug mixtures are described. Administration of a racemic drug mixture is in reality administration of two drugs with distinct pharmacokinetic and pharmacodynamic properties. Compared with the active enantiomer, the inactive enantiomer in a racemic mixture often has different rates of absorption, metabolism, and excretion, as well as different affinities for tissue receptor and protein receptor binding sites. It may be an agonist or antagonist, produce adverse effects, increase efficacy, or place an undue burden on clearance mechanisms. Thus, the pharmacokinetic and pharmacodynamic properties, pharmacologic activity, and toxicity of each enantiomer in a racemic drug mixture need to be determined. When pharmacokinetics of enantiomers differ, the contribution of each enantiomer to effectiveness and toxicity and whether the mixture may be more beneficial than a single enantiomer will need to be considered before racemic mixtures are marketed.

Animals↗
PubMed1979

Rheumatology.

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HLA Antigens↗
PubMed1978

Fungal arthritis.

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Arthritis, Infectious↗
PubMed1978

Rheumatology.

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Antibodies, Antinuclear↗
PubMed1978

Multicenter comparison of naproxen and indomethacin in rheumatoid arthritis.

In a double-blind, crossover study, naproxen, 250 mg twice a day, naproxen, 500 mg taken at bedtime, and indomethacin, 25 mg four times a day, were compared in 132 patients with rheumatoid arthritis; six centers participated in the study. Objective indices of arthritis activity, such as number of clinically active joints, walking time, and duration of morning stiffness, were nearly identical for the three treatment regimens. Of particular interest was the observation that efficacy of a single daily dose of naproxen was comparable to that of the twice-daily dosage. Naproxen was better tolerated than indomethacin, as shown by a statistically significant difference in the incidence of CNS complaints.

Adult↗
PubMed1978

Osteoarthritis.

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Arthritis, Rheumatoid↗
PubMed1977

Free DNA in the serum of rheumatoid arthritis patients.

Seventy patients with classical or definite rheumatoid arthritis (RA) were studied in an attempt to correlate the serum levels of free DNA with other features. In 26 patients (37%), levels of DNA ranging from 100-540 ng/ml, with a mean of 187 ng/ml, were found. In additional seven patients with a mean of 257 ng/ml, low levels of anti-DNA-antibody were observed. The remaining of 37 patients (53%) had levels of 0-80 ng/ml in their sera, with a mean of 39 ng/ml. All three groups differed significantly (p less than 0.01) from the control group of 61 healthy individuals, who had levels of 0-80 ng/ml with a mean of 13 ng/ml. The high levels of free DNA were commonly found in patients with more severe symptoms who had active RA for less than 10 years, whereas patients with longer duration of disease showed lower levels of DNA. In addition, elevated DNA levels were found more commonly in patients seronegative for rheumatoid factor (RF). Other clinical features did not show significant differences among these patients. The implications of these findings to the pathogenesis of the disease are discussed.

Arthritis, Rheumatoid↗
PubMed1976

Response of osteoarthritis to ibuprofen or flurbiprofen.

Flurbiprofen and ibuprofen, two propionic acid derivatives with anti-inflammatory and analgesic activity, were compared in a double-blind multiclinic study in 195 patients with osteoarthritis of the peripheral joints. The patients were given 80 mg/day flurbiprofen or 1600 mg/day ibuprofen for six weeks. Pain, subjective evaluation and functional tests improved significantly in both groups. There were no statistically significant differences between the two treatments in any of the responses. Gastro-intestinal side-effects, generally mild, developed in 5-6% of the patients.

Aged↗