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Biomedical subjects

G E Digenis

Publications and source records attributed to G E Digenis.

22 records · Page 2Linked to original sources
PubMed1983

Ultrastructure of normal rabbit mesentery.

The ultrastructure of the mesentery was examined by electron microscope (EM) after in vivo fixation in 7 normal rabbits. In 1, the fixation was performed after intravenous injection of an electron-dense tracer (iron dextran) and intraperitoneal infusion of dialysate 4.25% for 1 h. We studied morphometric data of what is considered to be the active peritoneal dialysis membrane, i.e. capillary endothelial cells, interstitium and mesothelial cells. The mesothelial cells are flattened and overlapping with tight junctions between them. They lie on a continuous basement membrane and they contain numerous intracytoplasmic vesicles, separated or in clusters. The mesenteric microvessels were mainly true capillaries of continuous type and postcapillary venules. Capillary lymphatics and larger lymphatic channels (lacunae) seem to be more extensive than the blood capillaries and venules. The endothelial cells contain many vesicles. The interstitium consists of bundles of collagen, fibroblasts and occasional macrophages. The electron-dense tracer was found in the vesicles of the mesothelial cells suggesting that vesicular transport may play an important part in the transportation of at least molecules of a certain size.

Animals↗
PubMedDate not supplied

On the usefulness of glycylglycine in hemodialysis and peritoneal dialysis solutions.

This article reviews current knowledge on the usefulness of glycylglycine in preparing single stable hemodialysis (HD) and peritoneal dialysis (PD) solutions containing bicarbonate. The coexistence of bicarbonate and glycylglycine in a dialysis solution renders it a potent, stable buffer in which the well known reactions between bicarbonate and calcium and magnesium, and the subsequent formation of insoluble neutral calcium and magnesium carbonate salts, are avoided. Single stable bicarbonate-glycylglycine (BiGG) solutions for HD and PD have been successfully prepared and studied, both experimentally and clinically. These studies have demonstrated the advantages of BiGG solutions in terms of simplicity, stability, convenience, tolerance, biocompatibility, protection of the peritoneum, and higher ultrafiltration, compared to standard acetate or lactate solutions, and on-line prepared bicarbonate solutions. Progressive accumulation of glycylglycine or glycine, even after prolonged use, side effects, or signs of toxicity were not observed. In conclusion, BiGG solutions ensure a physiologic dialysis both from the theoretic and practical points of view.

Acetates↗