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G E Bradley

Publications and source records attributed to G E Bradley.

5 recordsLinked to original sources
PubMed1994

Patients who leave emergency departments without being seen by a physician: magnitude of the problem in Los Angeles County.

STUDY OBJECTIVES: To determine the hospital characteristics associated with patients leaving emergency departments prior to physician evaluation. DESIGN: Cross-sectional design with data collection by mail and telephone survey. SETTING: Los Angeles County, California. TYPE OF PARTICIPANTS: Convenience sample of four public and 26 private hospital EDs with a combined monthly volume of 92,570. INTERVENTIONS: None. RESULTS: Questionnaires were returned from 83% of EDs surveyed. During 1990, 4.2% of patients at these EDs left without being seen by a physician. In all, 7.3% of public hospital patients left without being seen, and 2.4% of private hospital patients left without being seen (P < .001). The percentage of patients who left without being seen was significantly higher at EDs with longer waiting times, higher fraction of uninsured patients, and at hospitals with accredited residency training programs (P < .001 for each comparison). A logistic regression model, used to simultaneously evaluate the effects of multiple correlated factors, revealed that waiting time, fraction of patients uninsured, and teaching status had independent positive associations with patients who left without being seen. CONCLUSION: More than 4% of patients who seek care at EDs in Los Angeles County leave without being seen by a physician. A greater proportion of patients leave without medical evaluation from EDs with long waiting times for ambulatory patients and from those that serve uninsured populations. These findings should be interpreted in light of existing data on the health consequences faced by patients who leave hospital EDs without treatment.

Adult↗
PubMed1990

Novel immunoregulatory functions of phenotypically distinct subpopulations of CD4+ cells in the human neonate.

Although normal numbers of CD4+ T cells are present in the human neonate, cord blood CD4+ cells are deficient in their ability to provide help for antibody production. In the present studies, we have examined the cellular basis for this functional deficit by analyzing the phenotypic properties and immunoregulatory functions of the subsets of cord blood CD4+ cells defined by anti-CD45RA mAb. In contrast to CD4+ cells from adults, greater than 90% of cord blood CD4+ cells expressed the CD45RA, CD38, and Leu-8 membrane Ag. When neonatal CD4+ cells were cultured with adult B cells and PWM or anti-CD4+ mAb, no helper function was apparent. However, when the small number of CD4+CD45RA- cells in cord blood were purified and similarly analyzed, helper activity comparable to that of adult CD4+CD45RA- cells was found. This helper function was profoundly suppressed by the presence of even small numbers of cord blood (but not adult) CD4+CD45RA+ cells. Irradiation of mitomycin C treatment of neonatal CD4+CD45RA+ cells abrogated their suppressor activity, but did not induce helper capability. However, after activation with PHA and culture in IL-2, cord blood CD4+CD45RA+ cells lost their suppressor activity and acquired the ability to provide help for B cell differentiation. This functional maturation was accompanied by their conversion to the CD4+CD45RA- phenotype. Thus, whereas cord blood CD4+CD45RA+ and CD4+CD45RA- cells share certain properties with the analogous subsets in adults, our data show that the dominant immunoregulatory function of cord blood CD4+ cells is suppression mediated by CD4+CD45RA+ (and CD38+) cells. In view of these phenotypic and functional differences between neonatal and adult CD4+CD45RA+ cells, we propose that "naive" CD4+CD45RA+ cells undergo age-related maturational changes that are unrelated to their postulated activation-dependent post-thymic differentiation into CD4+CD45RA- "memory" cells capable of helper functions.

ADP-ribosyl Cyclase↗
PubMed1976

IgA nephropathy: a report on three cases.

Three cases are presented of a recently defined group of patients with renal disease who presented with macroscopic or persisted microscopic haematuria. These patients were found to have deposition of IgA in the glomerulus. They may thus be classified as suffering from an immunologically related glomerulonephritis.

Adult↗
PubMed1976

Malakoplakia of the testis.

Two cases of malakoplakia of the testis are presented. Malakoplakia (soft plaque) is an uncommon chronic inflammatory condition of granulomatous type, the common denominator of which would appear to be an altered reactivity of macrophages. Its hallmark is the presence of Michaelis-Guttman bodies. Until the late 1950s, when a case involving the testis was described, the condition was thought to involve only the mucosae of the bladder, ureters, and renal pelvis. The most recent review of malakoplakia of the testis included only 10 known cases.

Adult↗