Ulcer due to Mycobacterium ulcerans in Northern Ireland.
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Biomedical subjects
Publications and source records attributed to G E Allen.
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Three age- and sex-matched groups of 30 patients with chronic plaque psoriasis were treated by photochemotherapy (PUVA). Groups I and II received routine maintenance PUVA therapy at different intervals and Group III had no maintenance treatment. The remission time after the clearance treatment with PUVA is compared with the total cumulative dose of long wave ultraviolet light (UVA). A lower mean dose of UVA (51.0 +/- 1.7 joules/cm(2)) in Group III (no maintenance PUVA) achieved a comparable remission period to that after larger cumulative doses following routine maintenance therapy (87.8 +/- 4.9 and 77.0 +/- 4.1 joules/cm(2) in Groups I and II).
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The frequency of HLA-A and -B antigens in fifty-nine patients with localized granuloma annulare was compared with the frequency in 200 blood donors. The frequencies of HLA-A29, -B14 and -B15 were increased significantly in the patient group, the increase of HLA-A29 remaining significant after correction for the number of antigens compared.
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Surface IgM on peripheral lymphocytes from pregnant women were passively acquired from autologous serum. These cytophilic IgM antibodies occurred as relatively large molecules, suggesting that they were in the form of complexes or aggregates. The lymphocytes involved were mainly B cells. It was postulated that the present findings could be a mechanism for the modulation of lymphocyte surface receptors by serum factors during pregnancy.
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Lymphocytes from peripheral blood of pregnant women were studied with the use of markers for membrane-bound immunoglobulins (B cells) and receptors for sheep erythrocytes (T cells). It was found that there was a significant increase in the number of IgM-bearing lymphocytes during pregnancy. This returned to normal levels after parturition.
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