The shrinking pool of plans.
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Biomedical subjects
Publications and source records attributed to G Dutton.
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Damage to the cerebral cortex was responsible for impairment in vision in 90 of 130 consecutive children referred to the Vision Assessment Clinic in Glasgow. Cortical blindness was seen in 16 children. Only 2 were mobile, but both showed evidence of navigational blind-sight. Cortical visual impairment, in which it was possible to estimate visual acuity but generalised severe brain damage precluded estimation of cognitive visual function, was observed in 9 children. Complex disorders of cognitive vision were seen in 20 children. These could be divided into five categories and involved impairment of: (1) recognition, (2) orientation, (3) depth perception, (4) perception of movement and (5) simultaneous perception. These disorders were observed in a variety of combinations. The remaining children showed evidence of reduced visual acuity and/ or visual field loss, but without detectable disorders of congnitive visual function. Early recognition of disorders of cognitive vision is required if active training and remediation are to be implemented.
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Retinal S antigen, a uveitogenic protein implicated in several forms of clinical and experimental uveoretinitis, has been localized by immunoelectron microscopy in the human photoreceptor outer segment using a protein A-gold technique and anti-bovine retinal S antigen serum. The protein was predominantly located to the proximal portion of the rod outer segment and appeared to be distributed on the disc membrane but not on the plasma membrane. No immunoreactive product was detected in cone outer segments or in any other retinal structure. These findings are discussed in relation to the physiological function of S antigen and its role in initiation of posterior uveitis.
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