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Biomedical subjects

G Dureau

Publications and source records attributed to G Dureau.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Tolerance and resistance of myocardium to anoxia: experimental studies.

We shall emphasize the notion of wide variability in the tolerance and resistance to anoxia of the myocardium, although the most important parameters are temperature and time. They can be modified widely by accompanying physical or biochemical conditions: --Cardiac distension and drugs inducing cardiac arrest; --Resuscitative perfusion; --The effect of some biochemical components is more likely explained by their possible action on the mitochondriae (glyoxilic acid-Isoproterenol). The study of the mitochondriae alone can explain the different behaviours of hearts subjected to anoxia in various situations.

Animals↗
PubMedDate not supplied

[Cyclosporine. Obscure sides of cardiac and pulmonary transplantations].

Cyclosporine therapy after heart and lung transplantation implies a number of specific aspects such as: kidney deficiency associated to heart failure, which delays its use as for cardiac transplantation; intestinal absorption disturbances that could be linked to the cystic fibrosis disease for lung transplantation. For both types of transplantation, local efficiency could indicate an interesting, but still unexplored therapeutic effect. Finally, it seems that the immunosuppressive effect could be linked to important pharmacological effect on calcium and could explain the specific aspects of rejection of patients under cyclosporine.

Cyclosporine↗
PubMedDate not supplied

Increased platelet aggregation after heart transplantation: influence of aspirin.

Accelerated graft coronary artery disease remains the most dramatic complication in long-term survivors of heart transplantation. The main purpose of this study was to evaluate ex vivo platelet function of heart transplant recipients as compared with that of healthy subjects and nontransplant coronary patients. The influence of aspirin, the chief antiplatelet agent, was also evaluated. The heart transplant recipients exhibited a marked platelet hyperaggregation to adenosine diphosphate as compared with the two control groups. In addition, platelets of the heart transplant recipients appeared to be resistant to the inhibitory effect of aspirin. These results could, at least partly, explain the failure of antiplatelet agents to prevent myocardial infarction in these patients.

Adenosine Diphosphate↗