Search PubMed⌕ Search

Biomedical subjects

G Duhamel

Publications and source records attributed to G Duhamel.

At least 109 records · Page 6Linked to original sources
PubMed1976

[Anatomo-pathologic forms of lymphoid and lymphoreticular fibrosis of the bone marrow].

The development, within the bone marrow, of reticulo-fibrosis with a lymphoid organ structure forms part of a pathological model common to several lympho- and reticulo-proliferative syndromes. Various cytological types develop within this reticulo-fibrous framework: lymphocytes, lymphoblasts, plasmocytes, "hairy cells" and histiocytes. This cytological variety has led to different names: leukaemic reticulo-endotheliosis, lymphoid myelofibrosis, histio-lymphocytosis, malignant histiocytosis, etc. Similar cell type sequence is seen in non-Hodgkins lymphomas, with the same problems of parent and daughter cells. In fact the architectural metaplasia of the bone marrow prevails over the cellular metaplasia in the definition of the single clinical, haematological nature and course of these syndromes which have been too widely dissociated by classical haematology.

Bone Marrow↗
PubMed1976

[Refractory anemia with partial myeloblastic medullary infiltration. Examination of marrow biopsies (author's transl)].

77 marrow biopsies of smouldering leukemia have been examined in triple blind fashion with the following results: the cellularity of the marrow is normal in three quarters of the cases. In one quarter the blast cells were homogenous, which confirms the diagnosis of leukemia. The frequences of the sheets of blast cells increase with the duration of the disease and reached 80% at the 20th month. In the other cases, blasts were seldom seen. Eosinophilia was frequent. Erythroblasts were always rare, in contrast to what is seen in sideroblastic anemias. The reticulin network was thickened in 25% of the cases. Thus, bone marrow biopsy may demonstrate many of the features supporting the diagnosis of smouldering leukemia.

Anemia, Aplastic↗
PubMed1975

[Acute transformation in 45 cases of chronic myeloid leukemia].

After a chronic phase, the average duration of which in this series was 38 months, the acute phase of myeloid leukemia was very short, not exceeding 7 months. The clinical signs which suggest an acute exacerbation are, in order of importance, increase in the volume of the spleen, changes in general health, fever. The blood signs, which are often found later than the clinical signs, are increased white cell count, anemia and marrow leukoblastosis higher than 20%. The laboratory criteria of acute exacerbation are of lesser importance. Chemotherapy gives very poor results at this stage.

Alkaline Phosphatase↗
PubMed1975

[Infections during malignant blood diseases. Value of the carbenicillin-gentamicin combination].

The association of carbenicillin and gentamicin was used as a routine in the early treatment of 48 attacks of fever, in 38 patients who mostly had acute leukemia and marrow aplasia. The attacks of infection may be classified as follows: 30% septicemia, 30% local infections, 40% no bacteria were identified. Among the septicemias, we noted 5 septicemias due to pyocyaneus, 4 due to klebsiella. On the whole, in the attacks of fever, the association of carbenicillin and gentamicin proved effective in 70% of cases, but a cure was obtained in only 56% of cases. In vitro, the association carbenicillin-gentamicin proved justified in 70% of cases. There was no special intolerance, apart from a few cases of hypokalemic alkalosis. The association carbenicillin-gentamicin, by its broad spectrum and especially in view of its elective effect on the pyocyaneus is an excellent initial form of antibiotic therapy, when faced with infection in a patient with malignant blood disease. However, it should be recognised that the efficacy of this association depends on the number of circulating polynuclear cells and that some bacteria, such as the klebsiella, are clear cells and that some bacteria, such as the klebsiella, are often resistant to this antibiotic association.

Anemia, Aplastic↗