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Biomedical subjects

G Duckworth

Publications and source records attributed to G Duckworth.

22 records · Page 2Linked to original sources

The international spread of methicillin-resistant Staphylococcus aureus.

A genetic analysis of representative methicillin-resistant Staphylococcus aureus (MRSA) being isolated in London and Dublin hospitals has demonstrated that the epidemic strains from two London hospitals are different from the Dublin strains, but indistinguishable from the epidemic strains of eastern Australia. The possibility that some strains of MRSA are more likely than others to spread within hospitals is discussed.

Australia↗

An enzyme activity in normal and ataxia telangiectasia cell lines which is involved in the repair of gamma-irradiation-induced DNA damage.

An enzyme that enhances the activity of DNA polymerase I (EC 2.7.7.7) for gamma-irradiated calf thymus DNA was demonstrated in cellular extracts of normal human fibroblasts and lymphoid-cell lines. This enzyme was found to be deficient in all cellular extracts of fibroblasts and lymphoid-cell lines examined from patients with the autosomal recessive disease ataxia telangiectasia. The activity in cellular extracts from normal fibroblasts was removed when heated to 100 degrees C for 2 min or when the assay was performed at 4 degrees C. No significant deficiency in primer-activating enzyme activity was observed in cell-free extracts of lymphoid lines from patients with xeroderma pigmentosum, Huntington's chorea or neurofibromatosis, or from an ataxia telangiectasia heterozygote.

Ataxia Telangiectasia↗

Reliability of psychiatric assessment in older patients.

A number of the causes of psychiatric diagnostic disagreement are discussed in this paper. The use of the Geriatric Mental Status interview to achieve diagnostic reliability is examined in three studies in which U.S.--U.K. Cross-National Project psychiatrists rated and diagnosed thirty-two British and twenty-one American patients. There were no systematic differences between U.S. and U.K. team members in their diagnoses; and agreement on six principal diagnostic categories was achieved in about three-quarters of the cases. The reliability fo the ratings of psychopathology that formed the basis for the diagnoses was satisfactory and is reported in detail.

Aged↗