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Biomedical subjects

G Ducel

Publications and source records attributed to G Ducel.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Influence of cimetidine on bacterial growth in gastric fluid (author's transl)].

Samples of gastric fluid were tested for pH and number of bacteria in 20 patients who received cimetidine 400 mg prior to selective gastric surgery. The results were compared with those obtained in a group of surgical patients who did not receive the drug. The cimetidine-treated patients had alkaline gastric fluid with pronounced bacterial growth (4.7 +/- 0.6 x 10(4) micro-organisms/ml), whereas 18/20 untreated patients has a sterile gastric fluid. Similar results were observed in 14 intensive care patients treated for 24 hours with cimetidine. The effect proved reversible: 12 hours after treatment was discontinued bacterial growth could only be demonstrated in 3/14 patients. Thus, short-term cimetidine treatment results in a rise of gastric pH with marked bacterial proliferation. This may have serious consequences in cimetidine-treated patients about to undergo gastric surgery or likely to develop aspiration pneumonia.

Bacteria↗
PubMed1982

[Evolution of the intestinal flora in patients under preventive treatment with cephalosporins].

The evolution of the intestinal flora has been studied in 20 patients undergoing chemoprophylaxis with cephalosporins. The patients, admitted to the Cantonal Hospital of Geneva for heart surgery, all received intravenous treatment initiated on the day of admission. Subsequently, one group continued to receive a cephalosporin orally while prophylaxis was discontinued in a second group. Microbiological analysis of aerobic bacteria in faeces demonstrated in both groups (1) a significant increase in resistance to beta-lactamines (ampicillin); (2) a parallel though lesser increase in resistance to other antibiotics (which shows the probable role of plasmids carrying drug resistance markers); and (3) an increase in bacteria known for their resistance to beta-lactamines (klebsiella, enterobacter, pseudomonas). These results demonstrate that a single intravenous administration of beta-lactamines has a selective effect on the intestinal flora and notably on bacteria which are known to be the cause of infectious diseases acquired in hospitals.

Administration, Oral↗
PubMed1976

[Halothane concentrations in the atmosphere of a paediatric operating theatre (author's transl)].

Determinations were made of the halothane concentrations in the air of a paediatric operating theatre during operations. They averaged 5-30 p.p.m. with peaks of 50-70 p.p.m. during induction. The inhalation of halothane vapour was confirmed by demonstrating bromine metabolites in the urine of the operating room personnel. The risk attendant on chronic exposure to halothane vapour should be prevented by the installation of suitable systems for the removal of excess anaesthetic vapours.

Adolescent↗
PubMed1975

[Harzard of chronic exposure to halothane for operating room personnel].

This study shows that the staff working in an operating room is repeatedly being exposed to appreciable doses of halothane vapours. A continuous measurement of the concentrations in the ambient air gave results ranging from 5 to 30 ppm. Summits from 50 to 70 ppm were noted. The inhaling of halothane was evidenced by the presence of brominated metabolites in the urine of the staff. A mean 14,59 mg/l was found with women anaesthesists. Therefore it is quite possible that the halothane spread in the air should be held responsible for the discomfort felt in particular by anaesthesists. To prevent this risk of chronic intoxication by those vapours, there ought to be a device permitting either to evacuate them outside or to collect them while regenerating the polluted air through an active carbon filter if one has not got at one's disposal an airing system offering over 20 renewals of fresh air per hour. The fitting up of a permanent control device equipped with warning light and bell is also justified.

Halothane↗
PubMedDate not supplied

[Noise in an intensive care unit].

An Intensive Care Unit is noisy. These Noises are made by the Machines and the Staff. Nose must be limited and also the patient isolated.

Equipment and Supplies, Hospital↗