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Biomedical subjects

G Draetta

Publications and source records attributed to G Draetta.

60 records · Page 4Linked to original sources

[Experimental research on the toxicity of PVC administered orally].

The AA. report the results of two experiments carried out on 24 rats Wistar treated with PVC dust ingestion. A group received 1 g of PVC dust in distilled water for only 15 days; the second group received PVC dust mixed with standard food almost 5 months till to 15 months. Pathological findings consist in marked hyperplasia of gastro-enteric mucosa, with polipoidfigures, and in a marked activation of pulmonary linforeticular tissue with cellular atipias. In one case a subcutaneous histiocytic lymphoma was observed.

Administration, Oral↗

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.

cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.

CDC2 Protein Kinase↗