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Biomedical subjects

G Dordain

Publications and source records attributed to G Dordain.

82 records · Page 5Linked to original sources
PubMedDate not supplied

[Vitamin B12, an analgesic vitamin? Critical examination of the literature].

Since 1950 it would seem that in some countries vitamin B12 has been regarded as a painkilling vitamin. Only one of the 94 published clinical trials fails to point to this conclusion, but none of these trials meets current methodological requirements for investigation of an analgesic. The hypothesis that vitamin B12 possesses painkilling properties must therefore be questioned, especially as no anti-nociceptive effect is reported in animal experiments.

Analgesics↗
PubMedDate not supplied

[During the treatment or after... drug-induced convulsive accidents. Apropos of 70 cases].

During a five year period (1988-1992) 70 cases of seizures were collected by the Adverse Drug Reaction Monitoring Center of Clermont-Ferrand (3.58% of total collected cases). 31 cases (22 M and 9 F) occurred after a drug withdrawal. Benzodiazepines--either alone or in association--were the most often involved. Mean age was 48.8 +/- 2.6 years in this group and additional factors (alcohol abuse and/or association of drugs that lower the seizure threshold) were associated in 26 cases. 39 cases (14 M and 25 F) occurred on the course of various treatments. The most frequently involved drugs were neuropsychiatric, antiinfectious (especially beta-lactam antibiotics, fluorquinolones and isoniazid) and theophylline. Mean age was 56.5 +/- 3.8 years and additional different factors (high dosages, antecedents of epilepsy, underlying diseases) were present in 22 observations.

Adverse Drug Reaction Reporting Systems↗
PubMedDate not supplied

[Pyridoxine neuropathies. Review of the literature].

Daily needs of vitamin B6 are very low (2 mg per day) and widely covered by normal feeding. Pyridoxine deficiencies are exceptional (congenital metabolic abnormalities, drug or toxic-induced perturbations). First described in animal models, human cases of neuropathy had been encountered in the "megavitamin"-syndrome. They are confirmed by rare case-reports of very high doses given in toxic indication. Sensory peripheral neuropathies can also occur with lower doses taken over a long period of time.

Adult↗