Search PubMed⌕ Search

Biomedical subjects

G Dobrescu

Publications and source records attributed to G Dobrescu.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Histoenzymological and ultrastructural changes of axillary lymph nodes with breast cancer metastases.

Histoenzymatic and ultrastructural changes were studied in axillary lymph nodes from patients with breast cancer by comparison between lymph nodes without metastases, with incipient metastases and completely metastatically transformed. Metastases is preceded by intense macrophagic reactions of lymph nodes, and prepared by the development of vascular stroma. Neoplastic cells in course of invasion presented an intense respiratory activity, while those replacing the lymphoid elements an accentuated synthesis of glycoproteins.

Acid Phosphatase↗
PubMedDate not supplied

Ultrastructural aspects in skin allergic vasculitis.

Twelve cases of skin allergic vasculitis were electronmicroscopically studied. The most striking changes were noticed at the level of capillaries, whose wall components were all affected, especially the endothelial cells. These presented at first adaptive changes, with swelling, microvillosities of plasmalemma protruding into the lumen, and many pinocytotic vesicles showing an intensely active transport. Followed different degrees of degenerative changes of cytoplasms and nuclei, the junctional complexes being interrupted, even discontinuous. The pericytes showed similar changes. The basement membrane was thickened, nonhomogeneous, with a spongy aspect, small discontinuities and some electron-dense depots. The endothelial cell damage and the discontinuity of basement membranes, as well as the alteration of pericytes allowed the migration of blood cells into interstitial spaces, followed by leucocytoclasia. As a consequence, in the perivascular tissue a polymorphous cellular infiltrate developed. The mechanisms and significance of these changes are discussed.

Capillaries↗
PubMedDate not supplied

[Tumors and cysts of the mesentery. Clinical and therapeutic study].

This study is based on a group of 34 primary tumours of the mesenterium which were treated in the first surgical Clinic between 1960 and 1981. In this series were 19 women and 15 men, and the age of the patients varied between 16 and 68 years, being in the average of 44 years. Ten cystic tumours were recorded, and 24 solid tumours. Nine of the tumours were benign and the remaining 25 were malignant. The cystic tumours, for the most of the benign type, were almost exclusively cystic lymphangiomas. One serous cyst was also recorded, as well as one hematic cyst, and one dermoid cyst that had underwent malignization. The solid tumours were all malignant, of the sarcomatous type,, and their starting point was the mesenteral connective-vascular structures. The clinical picture of the mesenteral tumours is polymorphous and non-characteristic. In the frame of paraclinical examinations the radiologic investigation holds an important place and this is especially true for selective arteriography of the upper mesenteric artery, which provides useful informations concerning the topography of the tumour in relation to the mesenteral vascular trunk. Therapeutic possibilities are discussed, and the fact is stressed that, for improving the prognosis an early diagnosis is essential.

Adolescent↗
PubMedDate not supplied

Liver ultrastructural changes following portal circulation disturbances.

Liver cell changes produced in rats by the ligature of the portal vein and of the spleen pedicle were studied by electron microscopy. There were differences in the liver response to the various types of circulatory disturbances. The earliest and most marked lesions of hepatic cells were noticed in the case of portal vein ligature, and occurred at the level of rough endoplasmic reticulum, mitochondria and lysosomes. No significant changes in Kupffer cells. When the spleen pedicle was ligated, the hepatic cell changes were less obvious, but the Kupffer cells changes were more prominent, testifying and increased hetero- and autophagy.

Animals↗
PubMedDate not supplied

[Cervicomediastinal and thoracic goiters].

Between 1950 and 1979 approximately 2400 patients with thyropathies have been operated in the I-st Surgical Clinic of Jassy. Of these 100 had cervico-mediastinal goiters, of which 79 were of the plunging cervico-mediastinal type, 18 were of the mediastino-cervical type and 3 were mediastinal goiters. The surgical treatment was applied in 98 patients, cervicotomy being sufficient to relieve the symptoms in 92 of the cases. The mixed approach (cervicosternotomy, or cervico-thoracic approach) were necessary in 5 cases, and the thoracic approach was selected in one case with an independent posterior mediastinal goiter. The immediate postoperative evolution, as well as the late evolution was good in most of the cases. Postoperative mortality was of 2 percent.

Adolescent↗